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Dhx15 DEAH-box helicase 15 [ Mus musculus (house mouse) ]

Gene ID: 13204, updated on 5-Nov-2024

Summary

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Official Symbol
Dhx15provided by MGI
Official Full Name
DEAH-box helicase 15provided by MGI
Primary source
MGI:MGI:1099786
See related
Ensembl:ENSMUSG00000029169 AllianceGenome:MGI:1099786
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DBP1; HRH2; DEAH9; Ddx15; mDEAH9
Summary
Predicted to enable RNA helicase activity and double-stranded RNA binding activity. Involved in antiviral innate immune response and defense response to bacterium. Predicted to be located in nuclear speck. Predicted to be part of U12-type spliceosomal complex and U2-type post-mRNA release spliceosomal complex. Is expressed in several structures, including aorta; forelimb bud; future brain; liver; and spleen. Orthologous to human DHX15 (DEAH-box helicase 15). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 55.8), CNS E14 (RPKM 38.2) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Dhx15 in Genome Data Viewer
Location:
5 C1; 5 27.51 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (52307545..52347888, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (52150203..52190546, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Neighboring gene predicted gene 42614 Neighboring gene STARR-seq mESC enhancer starr_13050 Neighboring gene STARR-seq mESC enhancer starr_13051 Neighboring gene STARR-seq mESC enhancer starr_13052 Neighboring gene STARR-seq mESC enhancer starr_13053 Neighboring gene STARR-seq mESC enhancer starr_13054 Neighboring gene STARR-seq mESC enhancer starr_13055 Neighboring gene RIKEN cDNA 9230114K14 gene Neighboring gene predicted gene, 40302 Neighboring gene microRNA 6417 Neighboring gene STARR-seq mESC enhancer starr_13057 Neighboring gene RIKEN cDNA C130083M11 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The RNA helicase DHX15 is a critical regulator of natural killer-cell homeostasis and functions. Wang G, et al. Cell Mol Immunol, 2022 Jun. PMID 35322175, Free PMC Article
  2. Ceria nanoparticles enhance endochondral ossification-based critical-sized bone defect regeneration by promoting the hypertrophic differentiation of BMSCs via DHX15 activation. Li J, et al. FASEB J, 2019 May. PMID 30776318
  3. Fusobacterium nucleatum promotes tumor progression in KRAS p.G12D-mutant colorectal cancer by binding to DHX15. Zhu H, et al. Nat Commun, 2024 Feb 24. PMID 38402201, Free PMC Article
  4. Identification of Dhx15 as a Major Regulator of Liver Development, Regeneration, and Tumor Growth in Zebrafish and Mice. Portolés I, et al. Int J Mol Sci, 2024 Mar 27. PMID 38612527, Free PMC Article
  5. TFIP11 interacts with mDEAH9, an RNA helicase involved in spliceosome disassembly. Wen X, et al. Int J Mol Sci, 2008 Nov. PMID 19165350, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of Dhx15 as a Major Regulator of Liver Development, Regeneration, and Tumor Growth in Zebrafish and Mice.
    Title: Identification of Dhx15 as a Major Regulator of Liver Development, Regeneration, and Tumor Growth in Zebrafish and Mice.
  2. Fusobacterium nucleatum promotes tumor progression in KRAS p.G12D-mutant colorectal cancer by binding to DHX15.
    Title: Fusobacterium nucleatum promotes tumor progression in KRAS p.G12D-mutant colorectal cancer by binding to DHX15.
  3. The RNA helicase DHX15 is a critical regulator of natural killer-cell homeostasis and functions.
    Title: The RNA helicase DHX15 is a critical regulator of natural killer-cell homeostasis and functions.
  4. DHX15 is required to control RNA virus-induced intestinal inflammation.
    Title: DHX15 is required to control RNA virus-induced intestinal inflammation.
  5. The loss of DHX15 impairs endothelial energy metabolism, lymphatic drainage and tumor metastasis in mice.
    Title: The loss of DHX15 impairs endothelial energy metabolism, lymphatic drainage and tumor metastasis in mice.
  6. The RNA helicase Dhx15 mediates Wnt-induced antimicrobial protein expression in Paneth cells.
    Title: The RNA helicase Dhx15 mediates Wnt-induced antimicrobial protein expression in Paneth cells.
  7. ceria nanoparticles significantly promoted endochondral ossification-based bone regeneration by ensuring sufficient hypertrophic differentiation via the activation of the RNA helicase, DEAH (Asp-Glu-Ala-His) box helicase 15, and its downstream target, p38 MAPK.
    Title: Ceria nanoparticles enhance endochondral ossification-based critical-sized bone defect regeneration by promoting the hypertrophic differentiation of BMSCs via DHX15 activation.
  8. These data demonstrate that Nlrp6 functions with Dhx15 as a viral RNA sensor to induce IFN-stimulated genes, and this effect is especially important in the intestinal tract.
    Title: Nlrp6 regulates intestinal antiviral innate immunity.
  9. DHX15, a DEXDc helicase family member, plays an important role in sensing RNA and RNA viruses in bone marrow dendritic cells.
    Title: DHX15 senses double-stranded RNA in myeloid dendritic cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC117685

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables double-stranded RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in antiviral innate immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in antiviral innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in antiviral innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to virus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to alkaloid IEA
Inferred from Electronic Annotation
more info
  
involved_in response to toxic substance IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of U12-type spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  
part_of U12-type spliceosomal complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of U2-type post-mRNA release spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  
part_of U2-type post-mRNA release spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ATP-dependent RNA helicase DHX15
Names
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 15 (RNA helicase A)
DEAH (Asp-Glu-Ala-His) box polypeptide 15
DEAH box protein 15
pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15
putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15
NP_001036085.1
NP_031865.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042620.2 → NP_001036085.1  ATP-dependent RNA helicase DHX15 isoform 1

    See identical proteins and their annotated locations for NP_001036085.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) contains an alternate 3' terminal exon, resulting in a different 3' UTR and 3' coding region, compared to variant 2. It encodes isoform 1, which has a shorter and distinct C-terminus, compared to isoform 2.
    Source sequence(s)
    AK043111, AK149869, BY285872
    Consensus CDS
    CCDS80280.1
    UniProtKB/TrEMBL
    Q3UDX4, Q497W9
    Related
    ENSMUSP00000143069.2, ENSMUST00000199321.5
    Conserved Domains (5) summary
    smart00490
    Location:382 → 475
    HELICc; helicase superfamily c-terminal domain
    smart00487
    Location:149 → 322
    DEXDc; DEAD-like helicases superfamily
    smart00847
    Location:545 → 628
    HA2; Helicase associated domain (HA2) Add an annotation
    cd00046
    Location:154 → 295
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam07717
    Location:662 → 701
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

  2. NM_007839.3 → NP_031865.2  ATP-dependent RNA helicase DHX15 isoform 2

    See identical proteins and their annotated locations for NP_031865.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
    Source sequence(s)
    AK145983, AK149869, BP767627, BY285872
    Consensus CDS
    CCDS39085.1
    UniProtKB/Swiss-Prot
    O35286, Q99L91
    UniProtKB/TrEMBL
    Q3TFE5, Q3UKJ6
    Related
    ENSMUSP00000031061.8, ENSMUST00000031061.12
    Conserved Domains (1) summary
    COG1643
    Location:124 → 763
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

RNA

  1. NR_104311.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site resulting in a shorter transcript, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK145983, AK168835, AK169174, BP767627, BY285872

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    52307545..52347888 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35286.2 GenPept UniProtKB/Swiss-Prot:O35286

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