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Dll3 delta like canonical Notch ligand 3 [ Mus musculus (house mouse) ]

Gene ID: 13389, updated on 5-Nov-2024

Summary

Official Symbol
Dll3provided by MGI
Official Full Name
delta like canonical Notch ligand 3provided by MGI
Primary source
MGI:MGI:1096877
See related
Ensembl:ENSMUSG00000003436 AllianceGenome:MGI:1096877
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
pu; pudgy
Summary
Predicted to enable Notch binding activity. Involved in skeletal system development. Acts upstream of or within anterior/posterior pattern specification; negative regulation of neurogenesis; and paraxial mesoderm development. Located in plasma membrane. Is expressed in several structures, including blastocyst; central nervous system; future brain; paraxial mesenchyme; and sensory organ. Used to study spondylocostal dysostosis. Human ortholog(s) of this gene implicated in dysostosis and spondylocostal dysostosis 1. Orthologous to human DLL3 (delta like canonical Notch ligand 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E11.5 (RPKM 28.4), whole brain E14.5 (RPKM 11.7) and 3 other tissues See more
Orthologs
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Genomic context

See Dll3 in Genome Data Viewer
Location:
7 A3; 7 16.67 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (27992980..28001210, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28293555..28301785, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4912 Neighboring gene EP300 interacting inhibitor of differentiation 2B Neighboring gene selenoprotein V Neighboring gene translocase of inner mitochondrial membrane 50 Neighboring gene STARR-positive B cell enhancer ABC_E6527 Neighboring gene predicted gene, 51445 Neighboring gene suppressor of Ty 5, DSIF elongation factor subunit Neighboring gene STARR-seq mESC enhancer starr_18409

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Radiation induced (1) 
  • Spontaneous (3)  1 citation
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Notch binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables Notch binding ISO
Inferred from Sequence Orthology
more info
 
enables Notch binding NAS
Non-traceable Author Statement
more info
PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in Notch signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cell fate determination NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within compartment pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in in utero embryonic development NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of astrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of neurogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nervous system development NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within paraxial mesoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in skeletal system development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within somitogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within somitogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within tissue development IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in endosome membrane TAS
Traceable Author Statement
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
delta-like protein 3
Names
M-Delta-3
delta-like 3
delta3
drosophila Delta homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007866.2NP_031892.2  delta-like protein 3 precursor

    See identical proteins and their annotated locations for NP_031892.2

    Status: VALIDATED

    Source sequence(s)
    BB868475, BC052002
    Consensus CDS
    CCDS39856.1
    UniProtKB/Swiss-Prot
    O35675, O88516, Q80W06, Q9QWL9, Q9QWZ7
    UniProtKB/TrEMBL
    Q3UND5
    Related
    ENSMUSP00000103951.4, ENSMUST00000108315.4
    Conserved Domains (3) summary
    cd00054
    Location:277308
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07657
    Location:2585
    MNNL; N terminus of Notch ligand
    cl19567
    Location:156246
    DSL; Delta serrate ligand

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    27992980..28001210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)