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Dnajc1 DnaJ heat shock protein family (Hsp40) member C1 [ Mus musculus (house mouse) ]

Gene ID: 13418, updated on 2-Nov-2024

Summary

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Official Symbol
Dnajc1provided by MGI
Official Full Name
DnaJ heat shock protein family (Hsp40) member C1provided by MGI
Primary source
MGI:MGI:103268
See related
Ensembl:ENSMUSG00000026740 AllianceGenome:MGI:103268
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MTJ1; ERdj1; ERj1p; Dnajl1; 4733401K02Rik; D230036H06Rik
Summary
Enables protein-folding chaperone binding activity. Acts upstream of or within protein folding and regulation of translation. Located in endoplasmic reticulum and plasma membrane. Orthologous to human DNAJC1 (DnaJ heat shock protein family (Hsp40) member C1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 10.4), thymus adult (RPKM 9.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dnajc1 in Genome Data Viewer
Location:
2 A3; 2 12.89 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (18210445..18402025, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (18205634..18394099, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10 Neighboring gene predicted gene, 25147 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene GAR1 ribonucleoprotein homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_03801 Neighboring gene STARR-seq mESC enhancer starr_03802 Neighboring gene STARR-positive B cell enhancer ABC_E11123 Neighboring gene STARR-seq mESC enhancer starr_03803 Neighboring gene STARR-seq mESC enhancer starr_03805 Neighboring gene STARR-seq mESC enhancer starr_03806 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:18424168-18424351 Neighboring gene STARR-seq mESC enhancer starr_03808 Neighboring gene STARR-seq mESC enhancer starr_03809 Neighboring gene STARR-seq mESC enhancer starr_03810 Neighboring gene STARR-positive B cell enhancer ABC_E11124 Neighboring gene nuclear encoded tRNA asparagine 9 (anticodon GTT) Neighboring gene STARR-seq mESC enhancer starr_03811 Neighboring gene aminoadipate-semialdehyde dehydrogenase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Isolation of a mouse cDNA encoding MTJ1, a new murine member of the DnaJ family of proteins. Brightman SE, et al. Gene, 1995 Feb 14. PMID 7875597
  2. ERj1p uses a universal ribosomal adaptor site to coordinate the 80S ribosome at the membrane. Blau M, et al. Nat Struct Mol Biol, 2005 Nov. PMID 16244660
  3. ERj1p has a basic role in protein biogenesis at the endoplasmic reticulum. Dudek J, et al. Nat Struct Mol Biol, 2005 Nov. PMID 16244664
  4. The role of MTJ-1 in cell surface translocation of GRP78, a receptor for alpha 2-macroglobulin-dependent signaling. Misra UK, et al. J Immunol, 2005 Feb 15. PMID 15699139
  5. Heterotrimeric Galphaq11 co-immunoprecipitates with surface-anchored GRP78 from plasma membranes of alpha2M*-stimulated macrophages. Misra UK, et al. J Cell Biochem, 2008 May 1. PMID 18213612

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that vaspin is a ligand for cell-surface GRP78 (glucose-regulated protein 78kD)/MTJ-1 complex; subsequent signal transduction exerts beneficial effects on endoplasmic reticulum stress-induced metabolic dysfunctions as seen in obesity.
    Title: Vaspin is an adipokine ameliorating ER stress in obesity as a ligand for cell-surface GRP78/MTJ-1 complex.
  2. plasma membrane-associated GRP78 is coupled to pertussis toxin-insensitive Galphaq11 and forms a ternary signaling complex with MTJ-1
    Title: Heterotrimeric Galphaq11 co-immunoprecipitates with surface-anchored GRP78 from plasma membranes of alpha2M*-stimulated macrophages.
  3. ERj1p inhibits translation in the absence of BiP, and mediates binding of the nuclear import factor importin beta and import into the nucleus.
    Title: ERj1p has a basic role in protein biogenesis at the endoplasmic reticulum.
  4. ERj1p coordinates the ribosome at the membrane and allosteric effects may mediate ERj1p's regulatory activity
    Title: ERj1p uses a universal ribosomal adaptor site to coordinate the 80S ribosome at the membrane.
  5. In addition to assisting the chaperone GRP78 in protein quality control in the endoplasmic reticulum, MTJ-1 is essential for transport of GRP78 to the macrophage surface, which serves a number of functions in immune regulation and signal transduction.
    Title: The role of MTJ-1 in cell surface translocation of GRP78, a receptor for alpha 2-macroglobulin-dependent signaling.
  6. ITIH4 and MTJ1 co-immunoprecipitate from total liver protein extracts and SANT domain of HTJ1 protects the ITIH4(588-930) recombinant fragment
    Title: BIP co-chaperone MTJ1/ERDJ1 interacts with inter-alpha-trypsin inhibitor heavy chain 4.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-folding chaperone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribosome binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within protein folding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein secretion ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regulation of translation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dnaJ homolog subfamily C member 1
Names
DnaJ (Hsp40) homolog, subfamily C, member 1
DnaJ-like protein 1
dnaJ protein homolog MTJ1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190817.2 → NP_001177746.1  dnaJ homolog subfamily C member 1 precursor

    See identical proteins and their annotated locations for NP_001177746.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL845265, AL928557, AL928620
    Consensus CDS
    CCDS15709.1
    UniProtKB/Swiss-Prot
    Q61712
    Related
    ENSMUSP00000088980.6, ENSMUST00000091418.12
    Conserved Domains (3) summary
    smart00717
    Location:493 → 542
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:494 → 541
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam00226
    Location:61 → 122
    DnaJ; DnaJ domain

  2. NM_007869.4 → NP_031895.1  dnaJ homolog subfamily C member 1 precursor

    See identical proteins and their annotated locations for NP_031895.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL845265, AL928557, AL928620
    Consensus CDS
    CCDS15709.1
    UniProtKB/Swiss-Prot
    Q61712
    Related
    ENSMUSP00000126321.2, ENSMUST00000166495.8
    Conserved Domains (3) summary
    smart00717
    Location:493 → 542
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:494 → 541
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam00226
    Location:61 → 122
    DnaJ; DnaJ domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    18210445..18402025 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011238947.3 → XP_011237249.1  dnaJ homolog subfamily C member 1 isoform X1

    Conserved Domains (2) summary
    cd00167
    Location:244 → 291
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    cl30717
    Location:103 → 243
    InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]

RNA

  1. XR_865923.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61712.1 GenPept UniProtKB/Swiss-Prot:Q61712

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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