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IRAK1BP1 interleukin 1 receptor associated kinase 1 binding protein 1 [ Homo sapiens (human) ]

Gene ID: 134728, updated on 3-Apr-2024

Summary

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Official Symbol
IRAK1BP1provided by HGNC
Official Full Name
interleukin 1 receptor associated kinase 1 binding protein 1provided by HGNC
Primary source
HGNC:HGNC:17368
See related
Ensembl:ENSG00000146243 MIM:615375; AllianceGenome:HGNC:17368
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AIP70; SIMPL
Summary
Predicted to be involved in I-kappaB kinase/NF-kappaB signaling. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 2.2), thyroid (RPKM 1.5) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
6q14.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (78867551..78979411)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (80045247..80113339)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (79577268..79612819)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene microRNA 10524 Neighboring gene NANOG hESC enhancer GRCh37_chr6:79289792-79290318 Neighboring gene uncharacterized LOC107986613 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:79568400-79568966 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24765 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:79577455-79578055 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:79680931-79681480 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:79681481-79682028 Neighboring gene tRNA-Phe (anticodon GAA) 8-1 Neighboring gene uncharacterized LOC124901346 Neighboring gene pleckstrin homology domain interacting protein Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:79756655-79757261 Neighboring gene nucleoporin 155kDa pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17345 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17346 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17347 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24767 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:79844665-79845165 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:79861851-79862574 Neighboring gene uncharacterized LOC124901347 Neighboring gene MPRA-validated peak5913 silencer

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Phosphorylation of SIMPL modulates RelA-associated NF-kappaB-dependent transcription. Luo Y, et al. Am J Physiol Cell Physiol, 2007 Mar. PMID 17079333
  2. Tumor necrosis factor alpha induction of NF-kappaB requires the novel coactivator SIMPL. Kwon HJ, et al. Mol Cell Biol, 2004 Nov. PMID 15485901, Free PMC Article
  3. Genome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese. He J, et al. Circ Cardiovasc Genet, 2013 Dec. PMID 24165912, Free PMC Article
  4. An Integrative Synthetic Biology Approach to Interrogating Cellular Ubiquitin and Ufm Signaling. Li C, et al. Int J Mol Sci, 2020 Jun 14. PMID 32545848, Free PMC Article
  5. Differential immune mechanism to HIV-1 Tat variants and its regulation by AEA [corrected]. Krishnan G, et al. Sci Rep, 2015 May 6. PMID 25943894, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat Primary human Muller glia cells treated with both HIV-1 clade B and clade C Tat upregulate the expression of interleukin-1 receptor-associated kinase 1 binding protein 1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ39542, MGC138458, MGC138460, 4921528N06Rik

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling adaptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in canonical NF-kappaB signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
interleukin-1 receptor-associated kinase 1-binding protein 1
Names
ActA binding protein 3
IRAK1-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010844.4 → NP_001010844.1  interleukin-1 receptor-associated kinase 1-binding protein 1

    See identical proteins and their annotated locations for NP_001010844.1

    Status: VALIDATED

    Source sequence(s)
    AL450327, BC112253, CB321683
    Consensus CDS
    CCDS34488.1
    UniProtKB/Swiss-Prot
    Q5VVH5
    Related
    ENSP00000358956.1, ENST00000369940.7
    Conserved Domains (1) summary
    pfam04402
    Location:56 → 197
    SIMPL; Protein of unknown function (DUF541)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    78867551..78979411
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047418194.1 → XP_047274150.1  interleukin-1 receptor-associated kinase 1-binding protein 1 isoform X4

  2. XM_006715336.4 → XP_006715399.1  interleukin-1 receptor-associated kinase 1-binding protein 1 isoform X1

    Conserved Domains (1) summary
    pfam04402
    Location:56 → 197
    SIMPL; Protein of unknown function (DUF541)

  3. XM_011535448.3 → XP_011533750.1  interleukin-1 receptor-associated kinase 1-binding protein 1 isoform X3

    Conserved Domains (1) summary
    pfam04402
    Location:56 → 112
    SIMPL; Protein of unknown function (DUF541)

  4. XM_011535447.2 → XP_011533749.1  interleukin-1 receptor-associated kinase 1-binding protein 1 isoform X2

    Conserved Domains (1) summary
    pfam04402
    Location:56 → 197
    SIMPL; Protein of unknown function (DUF541)

  5. XM_047418193.1 → XP_047274149.1  interleukin-1 receptor-associated kinase 1-binding protein 1 isoform X5

    Related
    ENSP00000475503.1, ENST00000607739.1

RNA

  1. XR_942279.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    80045247..80113339
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054354254.1 → XP_054210229.1  interleukin-1 receptor-associated kinase 1-binding protein 1 isoform X1

  2. XM_054354256.1 → XP_054210231.1  interleukin-1 receptor-associated kinase 1-binding protein 1 isoform X3

  3. XM_054354257.1 → XP_054210232.1  interleukin-1 receptor-associated kinase 1-binding protein 1 isoform X4

  4. XM_054354255.1 → XP_054210230.1  interleukin-1 receptor-associated kinase 1-binding protein 1 isoform X2

RNA

  1. XR_008487253.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5VVH5.1 GenPept UniProtKB/Swiss-Prot:Q5VVH5

Gene LinkOut

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