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Ebf3 early B cell factor 3 [ Mus musculus (house mouse) ]

Gene ID: 13593, updated on 2-Nov-2024

Summary

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Official Symbol
Ebf3provided by MGI
Official Full Name
early B cell factor 3provided by MGI
Primary source
MGI:MGI:894289
See related
Ensembl:ENSMUSG00000010476 AllianceGenome:MGI:894289
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
O/E-2; mKIAA4201; 3110018A08Rik
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within positive regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; limb; musculoskeletal system; and sensory organ. Human ortholog(s) of this gene implicated in hypotonia, ataxia, and delayed development syndrome. Orthologous to human EBF3 (EBF transcription factor 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E14 (RPKM 24.6), limb E14.5 (RPKM 23.6) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Ebf3 in Genome Data Viewer
Location:
7 F3- F4; 7 82.26 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (136795400..136924528, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (137193671..137322805, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene O-6-methylguanine-DNA methyltransferase Neighboring gene predicted gene, 39108 Neighboring gene STARR-seq mESC enhancer starr_20380 Neighboring gene STARR-seq mESC enhancer starr_20381 Neighboring gene predicted gene, 30061 Neighboring gene STARR-seq mESC enhancer starr_20382 Neighboring gene predicted gene 10578 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:144481070-144481271 Neighboring gene STARR-seq mESC enhancer starr_20383 Neighboring gene RIKEN cDNA 9430038I01 gene Neighboring gene STARR-positive B cell enhancer ABC_E2852 Neighboring gene nucleolin pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ebf3(+) niche-derived CXCL12 is required for the localization and maintenance of hematopoietic stem cells. Nakatani T, et al. Nat Commun, 2023 Oct 25. PMID 37880234, Free PMC Article
  2. Ebf3-miR218 regulation is involved in the development of dopaminergic neurons. Baek S, et al. Brain Res, 2014 Oct 31. PMID 25192643
  3. A Prdm8 target gene Ebf3 regulates multipolar-to-bipolar transition in migrating neocortical cells. Iwai R, et al. Biochem Biophys Res Commun, 2018 Jan 1. PMID 29113800
  4. The characterization of the Olf-1/EBF-like HLH transcription factor family: implications in olfactory gene regulation and neuronal development. Wang SS, et al. J Neurosci, 1997 Jun 1. PMID 9151732, Free PMC Article
  5. Early B Cell Factor 3 (EBF3) attenuates Parkinson's disease through directly regulating contactin-associated protein-like 4 (CNTNAP4) transcription: An experimental study. Hu W, et al. Cell Signal, 2024 Jun. PMID 38479556

See all (88) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Early B Cell Factor 3 (EBF3) attenuates Parkinson's disease through directly regulating contactin-associated protein-like 4 (CNTNAP4) transcription: An experimental study.
    Title: Early B Cell Factor 3 (EBF3) attenuates Parkinson's disease through directly regulating contactin-associated protein-like 4 (CNTNAP4) transcription: An experimental study.
  2. Ebf3[+] niche-derived CXCL12 is required for the localization and maintenance of hematopoietic stem cells.
    Title: Ebf3(+) niche-derived CXCL12 is required for the localization and maintenance of hematopoietic stem cells.
  3. The caudo-ventral pallium is a novel pallial domain expressing Gdf10 and generating Ebf3-positive neurons of the medial amygdala.
    Title: The caudo-ventral pallium is a novel pallial domain expressing Gdf10 and generating Ebf3-positive neurons of the medial amygdala.
  4. HSC cellular niches express Ebf3 that is required to create HSC niches, to inhibit their osteoblast differentiation, and to maintain spaces for HSCs.
    Title: Stem cell niche-specific Ebf3 maintains the bone marrow cavity.
  5. data show that Prdm13 is not required for amacrine fate as a class, but is essential for the formation of Ebf3+ amacrine cell subtypes. Rather than driving subtype identity, Prdm13 may act by restricting competing fate programs to maintain identity and survival.
    Title: Prdm13 is required for Ebf3+ amacrine cell formation in the retina.
  6. Our findings highlight the critical role of Ebf3 in multipolar-to-bipolar transition via positive feedback regulation of NeuroD1 in the developing neocortex.
    Title: A Prdm8 target gene Ebf3 regulates multipolar-to-bipolar transition in migrating neocortical cells.
  7. Ebf3 is a new regulator of terminal muscle differentiation in the diaphragm, and Ebf factors cooperate with MyoD in the induction of muscle-specific genes
    Title: Ebf factors and MyoD cooperate to regulate muscle relaxation via Atp2a1.
  8. The regulation of Ebf3 expression by miR218 controls the terminal differentiation of dopaminergic neurons.
    Title: Ebf3-miR218 regulation is involved in the development of dopaminergic neurons.
  9. Ebf2 and Ebf3, singly or together, control the migration of Cajal-Retzius cells arising in the cortical hem. These findings provide evidence that Ebfs directly regulate Cajal-Retzius cell development
    Title: Early B-cell factors 2 and 3 (EBF2/3) regulate early migration of Cajal-Retzius cells from the cortical hem.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (6) 
  • Targeted (6)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4201

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
transcription factor COE3
Names
EBF-3
OE-2
Olf-1/EBF-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113414.2 → NP_001106885.1  transcription factor COE3 isoform 2

    See identical proteins and their annotated locations for NP_001106885.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternative, in-frame donor splice site at one of the internal coding exons, compared to transcript variant 1. This results in a shorter isoform (2) that is missing a 9 aa segment, compared to isoform 1.
    Source sequence(s)
    AC135639
    Consensus CDS
    CCDS52423.1
    UniProtKB/TrEMBL
    Q6NXL3, Q8CBL7
    Related
    ENSMUSP00000132563.3, ENSMUST00000169486.9
    Conserved Domains (3) summary
    cd01175
    Location:254 → 338
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:339 → 382
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  2. NM_001113415.2 → NP_001106886.1  transcription factor COE3 isoform 1

    See identical proteins and their annotated locations for NP_001106886.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1)
    Source sequence(s)
    AC135639
    Consensus CDS
    CCDS52422.1
    UniProtKB/Swiss-Prot
    O08791, O08793
    UniProtKB/TrEMBL
    Q8CBL7
    Related
    ENSMUSP00000147829.2, ENSMUST00000210774.2
    Conserved Domains (3) summary
    cd01175
    Location:263 → 347
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:348 → 391
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  3. NM_010096.4 → NP_034226.1  transcription factor COE3 isoform 3

    See identical proteins and their annotated locations for NP_034226.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate, in-frame donor acceptor site at the penultimate coding exon, and an alternative, in-frame donor splice site at one of the internal coding exons, compared to transcript variant 1. This results in a shorter isoform (3) that is missing 36 aa and 9 aa segments, compared to isoform 1.
    Source sequence(s)
    AC135639
    Consensus CDS
    CCDS21946.1
    UniProtKB/TrEMBL
    Q5DTH8
    Related
    ENSMUSP00000033378.6, ENSMUST00000033378.13
    Conserved Domains (3) summary
    cd01175
    Location:254 → 338
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:339 → 382
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    136795400..136924528 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152643.1 → XP_036008536.1  transcription factor COE3 isoform X1

    UniProtKB/TrEMBL
    Q8CBL7
    Conserved Domains (3) summary
    cd01175
    Location:263 → 347
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:348 → 391
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  2. XM_036152647.1 → XP_036008540.1  transcription factor COE3 isoform X3

    UniProtKB/TrEMBL
    Q8CBL7
    Conserved Domains (3) summary
    cd01175
    Location:254 → 338
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:339 → 382
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  3. XM_036152646.1 → XP_036008539.1  transcription factor COE3 isoform X3

    UniProtKB/TrEMBL
    Q8CBL7
    Conserved Domains (3) summary
    cd01175
    Location:254 → 338
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:339 → 382
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  4. XM_036152645.1 → XP_036008538.1  transcription factor COE3 isoform X1

    UniProtKB/TrEMBL
    Q8CBL7
    Conserved Domains (3) summary
    cd01175
    Location:263 → 347
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:348 → 391
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  5. XM_036152644.1 → XP_036008537.1  transcription factor COE3 isoform X1

    UniProtKB/TrEMBL
    Q8CBL7
    Conserved Domains (3) summary
    cd01175
    Location:263 → 347
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:348 → 391
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  6. XM_006507334.3 → XP_006507397.1  transcription factor COE3 isoform X10

    UniProtKB/TrEMBL
    Q5DTH8
    Conserved Domains (3) summary
    cd01175
    Location:263 → 347
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:348 → 391
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  7. XM_006507336.3 → XP_006507399.1  transcription factor COE3 isoform X14

    See identical proteins and their annotated locations for XP_006507399.1

    UniProtKB/TrEMBL
    Q5DTH8
    Conserved Domains (3) summary
    cd01175
    Location:263 → 347
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:348 → 391
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  8. XM_006507331.3 → XP_006507394.1  transcription factor COE3 isoform X2

    UniProtKB/TrEMBL
    Q8CBL7
    Conserved Domains (3) summary
    cd01175
    Location:263 → 347
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:348 → 391
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  9. XM_030242085.2 → XP_030097945.1  transcription factor COE3 isoform X1

    UniProtKB/TrEMBL
    Q8CBL7
    Conserved Domains (3) summary
    cd01175
    Location:263 → 347
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:348 → 391
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  10. XM_030242086.2 → XP_030097946.1  transcription factor COE3 isoform X4

    UniProtKB/TrEMBL
    Q5DTH8
    Conserved Domains (3) summary
    cd01175
    Location:254 → 338
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:339 → 382
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  11. XM_030242094.2 → XP_030097954.1  transcription factor COE3 isoform X17

    UniProtKB/TrEMBL
    Q5DTH8
    Conserved Domains (3) summary
    cd01175
    Location:263 → 347
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16423
    Location:348 → 391
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain

  12. XM_030242092.2 → XP_030097952.1  transcription factor COE3 isoform X13

    UniProtKB/TrEMBL
    Q5DTH8
    Conserved Domains (3) summary
    cd01175
    Location:263 → 347
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:348 → 391
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  13. XM_006507333.3 → XP_006507396.1  transcription factor COE3 isoform X6

    UniProtKB/TrEMBL
    Q5DTH8
    Conserved Domains (3) summary
    cd01175
    Location:263 → 347
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:348 → 391
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  14. XM_030242095.2 → XP_030097955.1  transcription factor COE3 isoform X18

    UniProtKB/TrEMBL
    Q5DTH8
    Conserved Domains (3) summary
    cd01175
    Location:254 → 338
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:339 → 382
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  15. XM_011241672.3 → XP_011239974.1  transcription factor COE3 isoform X15

    See identical proteins and their annotated locations for XP_011239974.1

    UniProtKB/TrEMBL
    Q5DTH8
    Conserved Domains (3) summary
    cd01175
    Location:254 → 338
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:339 → 382
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  16. XM_006507332.3 → XP_006507395.1  transcription factor COE3 isoform X3

    UniProtKB/TrEMBL
    Q8CBL7
    Conserved Domains (3) summary
    cd01175
    Location:254 → 338
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:339 → 382
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  17. XM_030242087.2 → XP_030097947.1  transcription factor COE3 isoform X5

    UniProtKB/TrEMBL
    Q5DTH8
    Conserved Domains (3) summary
    cd01175
    Location:263 → 347
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:348 → 391
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  18. XM_030242088.2 → XP_030097948.1  transcription factor COE3 isoform X7

    UniProtKB/TrEMBL
    Q5DTH8
    Conserved Domains (3) summary
    cd01175
    Location:254 → 338
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:339 → 382
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  19. XM_030242093.2 → XP_030097953.1  transcription factor COE3 isoform X16

    UniProtKB/TrEMBL
    Q5DTH8
    Conserved Domains (3) summary
    cd01175
    Location:254 → 338
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:339 → 382
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  20. XM_036152651.1 → XP_036008544.1  transcription factor COE3 isoform X21

    Conserved Domains (3) summary
    cd01175
    Location:47 → 131
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16423
    Location:132 → 175
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain
    cl17007
    Location:1 → 40
    COE_DBD; Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain

  21. XM_036152650.1 → XP_036008543.1  transcription factor COE3 isoform X20

    Conserved Domains (3) summary
    cd01175
    Location:56 → 140
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16423
    Location:141 → 184
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain
    cl17007
    Location:1 → 40
    COE_DBD; Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain

  22. XM_036152652.1 → XP_036008545.1  transcription factor COE3 isoform X22

    Conserved Domains (3) summary
    cd01175
    Location:47 → 131
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16423
    Location:132 → 175
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain
    cl17007
    Location:1 → 40
    COE_DBD; Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain

  23. XM_030242090.2 → XP_030097950.1  transcription factor COE3 isoform X9

    UniProtKB/TrEMBL
    Q6NXL3, Q8CBL7
    Related
    ENSMUSP00000101724.4, ENSMUST00000106118.10
    Conserved Domains (3) summary
    cd01175
    Location:254 → 338
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:339 → 382
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  24. XM_006507335.3 → XP_006507398.1  transcription factor COE3 isoform X11

    See identical proteins and their annotated locations for XP_006507398.1

    UniProtKB/TrEMBL
    Q5DTH8
    Conserved Domains (3) summary
    cd01175
    Location:263 → 347
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:348 → 391
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  25. XM_036152653.1 → XP_036008546.1  transcription factor COE3 isoform X23

    UniProtKB/TrEMBL
    Q3UUB6
    Related
    ENSMUSP00000147512.2, ENSMUST00000209578.2
    Conserved Domains (3) summary
    cd01175
    Location:47 → 131
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16423
    Location:132 → 175
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain
    cl17007
    Location:1 → 40
    COE_DBD; Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain

  26. XM_030242091.2 → XP_030097951.1  transcription factor COE3 isoform X12

    UniProtKB/TrEMBL
    Q5DTH8
    Conserved Domains (3) summary
    cd01175
    Location:254 → 338
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:339 → 382
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  27. XM_030242089.2 → XP_030097949.1  transcription factor COE3 isoform X8

    UniProtKB/TrEMBL
    Q5DTH8
    Conserved Domains (3) summary
    cd01175
    Location:254 → 338
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:339 → 382
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  28. XM_006507337.5 → XP_006507400.1  transcription factor COE3 isoform X19

    Conserved Domains (3) summary
    cd01175
    Location:263 → 347
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:348 → 391
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08791.1 GenPept UniProtKB/Swiss-Prot:O08791

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