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Egr4 early growth response 4 [ Mus musculus (house mouse) ]

Gene ID: 13656, updated on 2-Nov-2024

Summary

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Official Symbol
Egr4provided by MGI
Official Full Name
early growth response 4provided by MGI
Primary source
MGI:MGI:99252
See related
Ensembl:ENSMUSG00000071341 AllianceGenome:MGI:99252
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NGFIC; NGF1-C; NGFI-C; pAT133
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; and tooth. Orthologous to human EGR4 (early growth response 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in frontal lobe adult (RPKM 10.9), cortex adult (RPKM 9.9) and 2 other tissues See more
Orthologs
human all
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Genomic context

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See Egr4 in Genome Data Viewer
Location:
6 C3; 6 37.48 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (85488103..85490571, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (85511121..85513589, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene protease-associated domain containing 1 Neighboring gene chaperonin containing TCP1 subunit 7 Neighboring gene F-box protein 41 Neighboring gene ALMS1, centrosome and basal body associated Neighboring gene STARR-seq mESC enhancer starr_16505 Neighboring gene STARR-seq mESC enhancer starr_16506 Neighboring gene N-acetyltransferase 8 (GCN5-related) family member 7 Neighboring gene ALMS1, centrosome and basal body associated, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. EGR4 is critical for cell-fate determination and phenotypic maintenance of geniculate ganglion neurons underlying sweet and umami taste. Dutta Banik D, et al. Proc Natl Acad Sci U S A, 2023 May 30. PMID 37216536, Free PMC Article
  2. Infertility associated with incomplete spermatogenic arrest and oligozoospermia in Egr4-deficient mice. Tourtellotte WG, et al. Development, 1999 Nov. PMID 10529423
  3. EGR4 displays both a cell- and intracellular-specific localization pattern in the developing murine testis. Hogarth CA, et al. Dev Dyn, 2010 Nov. PMID 20925118, Free PMC Article
  4. Cloning and characterization of the bovine EGR4 gene and evaluation as candidate gene for bovine spinal dysmyelination. Nissen PH, et al. Anim Genet, 2003 Apr. PMID 12648095
  5. Genomic organization, chromosomal localization and promoter function of the human zinc-finger gene pAT133. Holst C, et al. Hum Mol Genet, 1993 Apr. PMID 8504297

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Suppression of Ca(2+) signals by EGR4 controls Th1 differentiation and anti-cancer immunity in vivo.
    Title: Suppression of Ca(2+) signals by EGR4 controls Th1 differentiation and anti-cancer immunity in vivo.
  2. Egr4 expression is triggered by trophic factor neurturin to upregulate K-Cl cotransporter KCC2 in immature neurons.
    Title: Neurturin evokes MAPK-dependent upregulation of Egr4 and KCC2 in developing neurons.
  3. Egr4 is an important component in the mechanism of BDNF-dependent KCC2 gene regulation via the ERK1/2 pathway in immature neurons.
    Title: Early growth response 4 mediates BDNF induction of potassium chloride cotransporter 2 transcription.
  4. Data suggest that Egr4 may regulate spermatogenesis at multiple steps, with roles in the dividing Sertoli cells, peritubular myoid cells, and the meiotic and elongating haploid germ cell populations.
    Title: EGR4 displays both a cell- and intracellular-specific localization pattern in the developing murine testis.
  5. An important role for Egr4 is indicated in the developmental upregulation of potassium-chloride cotransporter (KCC2) gene expression.
    Title: Upregulation of the neuron-specific K+/Cl- cotransporter expression by transcription factor early growth response 4.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
early growth response protein 4
Names
EGR-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020596.3 → NP_065621.1  early growth response protein 4

    See identical proteins and their annotated locations for NP_065621.1

    Status: VALIDATED

    Source sequence(s)
    AK141637, BX528200
    Consensus CDS
    CCDS20297.1
    UniProtKB/Swiss-Prot
    Q9WUF2
    UniProtKB/TrEMBL
    Q3URA9
    Related
    ENSMUSP00000093433.4, ENSMUST00000095759.5
    Conserved Domains (4) summary
    COG5048
    Location:400 → 458
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:374 → 396
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:372 → 396
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:416 → 441
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    85488103..85490571 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WUF2.1 GenPept UniProtKB/Swiss-Prot:Q9WUF2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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