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Eif2b4 eukaryotic translation initiation factor 2B, subunit 4 delta [ Mus musculus (house mouse) ]

Gene ID: 13667, updated on 2-Nov-2024

Summary

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Official Symbol
Eif2b4provided by MGI
Official Full Name
eukaryotic translation initiation factor 2B, subunit 4 deltaprovided by MGI
Primary source
MGI:MGI:95300
See related
Ensembl:ENSMUSG00000029145 AllianceGenome:MGI:95300
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Eif2b
Summary
Predicted to enable translation initiation factor binding activity. Predicted to contribute to guanyl-nucleotide exchange factor activity and translation initiation factor activity. Predicted to be involved in several processes, including T cell receptor signaling pathway; nervous system development; and response to glucose. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 2B complex. Is expressed in several structures, including adipose tissue; brain; eye; gut gland; and male reproductive gland or organ. Used to study leukoencephalopathy with vanishing white matter. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter 4. Orthologous to human EIF2B4 (eukaryotic translation initiation factor 2B subunit delta). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 32.0), thymus adult (RPKM 17.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Eif2b4 in Genome Data Viewer
Location:
5 B1; 5 17.24 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (31344902..31350483, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (31187558..31193139, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene MpV17 mitochondrial inner membrane protein Neighboring gene general transcription factor IIIC, polypeptide 2, beta Neighboring gene STARR-seq mESC enhancer starr_12767 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:31495236-31495423 Neighboring gene sorting nexin 17 Neighboring gene zinc finger protein 513

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Pridopidine subtly ameliorates motor skills in a mouse model for vanishing white matter. Oudejans E, et al. Life Sci Alliance, 2024 Mar. PMID 38171595, Free PMC Article
  2. The delta-subunit of murine guanine nucleotide exchange factor eIF-2B. Characterization of cDNAs predicts isoforms differing at the amino-terminal end. Henderson RA, et al. J Biol Chem, 1994 Dec 2. PMID 7982969
  3. Astrocytes are central in the pathomechanisms of vanishing white matter. Dooves S, et al. J Clin Invest, 2016 Apr 1. PMID 26974157, Free PMC Article
  4. Vanishing white matter: deregulated integrated stress response as therapy target. Abbink TEM, et al. Ann Clin Transl Neurol, 2019 Aug. PMID 31402619, Free PMC Article
  5. Lithium: effects in animal models of vanishing white matter are not promising. Witkamp D, et al. Front Neurosci, 2024. PMID 38352041, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
contributes_to translation initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to translation initiation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables translation initiation factor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in T cell receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cytoplasmic translational initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoplasmic translational initiation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in myelination ISO
Inferred from Sequence Orthology
more info
  
involved_in myelination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in oligodendrocyte development ISO
Inferred from Sequence Orthology
more info
  
involved_in oligodendrocyte development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ovarian follicle development ISO
Inferred from Sequence Orthology
more info
  
involved_in ovarian follicle development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to glucose ISO
Inferred from Sequence Orthology
more info
  
involved_in response to heat ISO
Inferred from Sequence Orthology
more info
  
involved_in response to peptide hormone ISO
Inferred from Sequence Orthology
more info
  
involved_in translational initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in translational initiation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 2B complex ISO
Inferred from Sequence Orthology
more info
  
part_of eukaryotic translation initiation factor 2B complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
translation initiation factor eIF2B subunit delta
Names
eIF-2B GDP-GTP exchange factor subunit delta
eIF2B GDP-GTP exchange factor subunit delta
translation initiation factor eIF-2B subunit delta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127355.1 → NP_001120827.1  translation initiation factor eIF2B subunit delta isoform 1

    See identical proteins and their annotated locations for NP_001120827.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1 and 3 encode the same isoform.
    Source sequence(s)
    AK158282, BB665023, BB857319, CD768292
    Consensus CDS
    CCDS51457.1
    UniProtKB/TrEMBL
    D3Z780
    Related
    ENSMUSP00000130880.2, ENSMUST00000166769.8
    Conserved Domains (2) summary
    COG1184
    Location:240 → 538
    GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
    pfam01008
    Location:240 → 530
    IF-2B; Initiation factor 2 subunit family

  2. NM_001127356.1 → NP_001120828.1  translation initiation factor eIF2B subunit delta isoform 1

    See identical proteins and their annotated locations for NP_001120828.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 3 encode the same isoform.
    Source sequence(s)
    AK158282, BB665023, BU707309, CD768292
    Consensus CDS
    CCDS51457.1
    UniProtKB/TrEMBL
    D3Z780
    Related
    ENSMUSP00000110250.2, ENSMUST00000114603.8
    Conserved Domains (2) summary
    COG1184
    Location:240 → 538
    GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
    pfam01008
    Location:240 → 530
    IF-2B; Initiation factor 2 subunit family

  3. NM_010122.2 → NP_034252.2  translation initiation factor eIF2B subunit delta isoform 2

    See identical proteins and their annotated locations for NP_034252.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a segment spanning the 5' UTR and 5' coding region, compared to variant 1, resulting in translation initiation from an alternate start codon and a shorter protein (isoform 2) with a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK158282, BB665023, CD768292
    Consensus CDS
    CCDS19176.1
    UniProtKB/Swiss-Prot
    Q3TYW7, Q61748, Q61749, Q8VC35
    UniProtKB/TrEMBL
    D3Z780
    Related
    ENSMUSP00000076875.4, ENSMUST00000077693.10
    Conserved Domains (2) summary
    COG1184
    Location:220 → 518
    GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
    pfam01008
    Location:220 → 510
    IF-2B; Initiation factor 2 subunit family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    31344902..31350483 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61749.2 GenPept UniProtKB/Swiss-Prot:Q61749

Gene LinkOut

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