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Eif4a1 eukaryotic translation initiation factor 4A1 [ Mus musculus (house mouse) ]

Gene ID: 13681, updated on 2-Nov-2024

Summary

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Official Symbol
Eif4a1provided by MGI
Official Full Name
eukaryotic translation initiation factor 4A1provided by MGI
Primary source
MGI:MGI:95303
See related
Ensembl:ENSMUSG00000059796 AllianceGenome:MGI:95303
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Eif4; Ddx2a; BM-010
Summary
Predicted to enable double-stranded RNA binding activity and translation initiation factor activity. Predicted to be involved in cytoplasmic translational initiation and positive regulation of transcription by RNA polymerase II. Predicted to be located in nuclear stress granule; perinuclear region of cytoplasm; and plasma membrane. Is expressed in several structures, including central nervous system; liver; lung; ovary; and sensory organ. Orthologous to human EIF4A1 (eukaryotic translation initiation factor 4A1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 322.5), placenta adult (RPKM 214.5) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Eif4a1 in Genome Data Viewer
Location:
11 B3; 11 42.86 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69557762..69563249, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69666936..69672423, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene microRNA 1934 Neighboring gene CD68 antigen Neighboring gene predicted gene, 24029 Neighboring gene predicted gene, 25835 Neighboring gene STARR-positive B cell enhancer ABC_E8419 Neighboring gene predicted gene, 22988 Neighboring gene STARR-positive B cell enhancer ABC_E734 Neighboring gene SUMO/sentrin specific peptidase 3 Neighboring gene tumor necrosis factor (ligand) superfamily, member 13, opposite strand Neighboring gene tumor necrosis factor (ligand) superfamily, membrane-bound member 13 Neighboring gene tumor necrosis factor (ligand) superfamily, member 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mutational analysis of a DEAD box RNA helicase: the mammalian translation initiation factor eIF-4A. Pause A, et al. EMBO J, 1992 Jul. PMID 1378397, Free PMC Article
  2. Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation. Bordeleau ME, et al. Proc Natl Acad Sci U S A, 2005 Jul 26. PMID 16030146, Free PMC Article
  3. Cloning of eukaryotic protein synthesis initiation factor genes: isolation and characterization of cDNA clones encoding factor eIF-4A. Nielsen PJ, et al. Nucleic Acids Res, 1985 Oct 11. PMID 3840589, Free PMC Article
  4. Differential expression of the murine eukaryotic translation initiation factor isogenes eIF4A(I) and eIF4A(II) is dependent upon cellular growth status. Williams-Hill DM, et al. Arch Biochem Biophys, 1997 Feb 1. PMID 9015395
  5. Sequestration of eIF4A by angiomotin: A novel mechanism to restrict global protein synthesis in trophoblast cells. Basak T, et al. Stem Cells, 2021 Feb. PMID 33237582

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNA helicase EIF4A1-mediated translation is essential for the GC response.
    Title: RNA helicase EIF4A1-mediated translation is essential for the GC response.
  2. Sequestration of eIF4A by angiomotin: A novel mechanism to restrict global protein synthesis in trophoblast cells.
    Title: Sequestration of eIF4A by angiomotin: A novel mechanism to restrict global protein synthesis in trophoblast cells.
  3. the central A-rich domains of BC RNAs target eIF4A, specifically inhibiting its RNA helicase activity
    Title: Dual nature of translational control by regulatory BC RNAs.
  4. analysis of the tandem MA-3 region of Pdcd4 protein and characterization of its interactions with eIF4A and eIF4G
    Title: Structure of the tandem MA-3 region of Pdcd4 protein and characterization of its interactions with eIF4A and eIF4G: molecular mechanisms of a tumor suppressor.
  5. The binding of pateamine to eIF4A presets the protein in the high-affinity RNA-binding state, which stimulates ATP binding, hydrolysis, and RNA unwinding.
    Title: Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation.
  6. Pdcd4 binding to eIF4A is linked to its transformation-suppressing activity, as Pdcd4-eIF4A binding and consequent inhibition of translation are required for Pdcd4 transrepression of AP-1.
    Title: The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation.
  7. interactions between Pdcd4 and components of the translation initiation complex, namely, the RNA helicase eIF4A and the scaffolding protein eIF4G
    Title: Structural basis for inhibition of translation by the tumor suppressor Pdcd4.
  8. analysis of cells of eIF4GIf molecules lacking either the PABP-binding site, the eIF3-binding site, the middle domain eIF4A-binding site, or the C-terminal segment that includes the second eIF4A-binding site
    Title: Functional analysis of individual binding activities of the scaffold protein eIF4G.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables translation initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic translational initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoplasmic translational initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in translational initiation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of eukaryotic translation initiation factor 4F complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nuclear stress granule ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
eukaryotic initiation factor 4A-I
Names
ATP-dependent RNA helicase eIF4A-1
eIF-4A-I
eIF4A-I
initiation factor eIF-4A long form
NP_001152847.1
NP_659207.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159375.1 → NP_001152847.1  eukaryotic initiation factor 4A-I isoform 2

    See identical proteins and their annotated locations for NP_001152847.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region that results in a frameshift, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL603707, AW493973
    UniProtKB/TrEMBL
    Q3TFG3, Q3TGK7, Q3TLL6, Q3UXC2, Q4FZL1
    Conserved Domains (3) summary
    smart00487
    Location:47 → 249
    DEXDc; DEAD-like helicases superfamily
    cd00079
    Location:246 → 359
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:34 → 235
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

  2. NM_144958.4 → NP_659207.1  eukaryotic initiation factor 4A-I isoform 1

    See identical proteins and their annotated locations for NP_659207.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK169030, AL603707, AW493973
    Consensus CDS
    CCDS24904.1
    UniProtKB/Swiss-Prot
    P60843
    UniProtKB/TrEMBL
    Q3TFG3, Q3TGK7, Q3UXC2, Q4FZL1, Q5F2A7
    Related
    ENSMUSP00000127034.3, ENSMUST00000163666.3
    Conserved Domains (1) summary
    PTZ00424
    Location:20 → 406
    PTZ00424; helicase 45; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    69557762..69563249 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P60843.1 GenPept UniProtKB/Swiss-Prot:P60843

Gene LinkOut

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