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Emp2 epithelial membrane protein 2 [ Mus musculus (house mouse) ]

Gene ID: 13731, updated on 2-Nov-2024

Summary

Official Symbol
Emp2provided by MGI
Official Full Name
epithelial membrane protein 2provided by MGI
Primary source
MGI:MGI:1098726
See related
Ensembl:ENSMUSG00000022505 AllianceGenome:MGI:1098726
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
XMP
Summary
Enables integrin binding activity. Involved in several processes, including early endosome to late endosome transport; embryonic process involved in female pregnancy; and protein localization to cell surface. Acts upstream of or within positive regulation of integrin-mediated signaling pathway. Located in Golgi apparatus; apical plasma membrane; and cell surface. Colocalizes with cytoplasmic vesicle; membrane raft; and plasma membrane. Is expressed in several structures, including alimentary system; endometrium; medulla oblongata lateral wall; respiratory system; and sensory organ. Used to study placental insufficiency. Human ortholog(s) of this gene implicated in nephrotic syndrome type 10. Orthologous to human EMP2 (epithelial membrane protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in lung adult (RPKM 388.0), bladder adult (RPKM 33.5) and 3 other tissues See more
Orthologs
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Genomic context

See Emp2 in Genome Data Viewer
Location:
16 A1; 16 5.54 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (10099613..10131832, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (10281749..10313968, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40073 Neighboring gene ribosomal protein L39-like Neighboring gene activating transcription factor 7 interacting protein 2 Neighboring gene STARR-seq mESC enhancer starr_40074 Neighboring gene STARR-seq mESC enhancer starr_40076 Neighboring gene predicted gene, 24667 Neighboring gene STARR-seq mESC enhancer starr_40077 Neighboring gene predicted gene 1600 Neighboring gene predicted gene, 30724

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (3)  1 citation

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in T cell mediated cytotoxicity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in actin filament organization ISO
Inferred from Sequence Orthology
more info
 
involved_in actin filament organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in actin-mediated cell contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in actin-mediated cell contraction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in activation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in bleb assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in bleb assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in blood vessel endothelial cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT involved_in caveola assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-matrix adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in early endosome to late endosome transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in embryo implantation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryo implantation ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic process involved in female pregnancy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in membrane raft assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in natural killer cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neutrophil migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in plasma membrane raft assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cardiac epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in protein localization to cell surface IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to cell surface ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cell-matrix adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of endothelial cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of glomerular filtration ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of glomerular filtration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of vasculogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of vasculogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
NOT colocalizes_with caveola IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
epithelial membrane protein 2
Names
EMP-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007929.2NP_031955.2  epithelial membrane protein 2

    See identical proteins and their annotated locations for NP_031955.2

    Status: VALIDATED

    Source sequence(s)
    AC154311, AK077260
    Consensus CDS
    CCDS37250.1
    UniProtKB/Swiss-Prot
    O88662
    UniProtKB/TrEMBL
    Q548I4, Q8CGC1
    Related
    ENSMUSP00000077466.5, ENSMUST00000078357.5
    Conserved Domains (1) summary
    pfam00822
    Location:1165
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    10099613..10131832 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)