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Epb41l4a erythrocyte membrane protein band 4.1 like 4a [ Mus musculus (house mouse) ]

Gene ID: 13824, updated on 2-Nov-2024

Summary

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Official Symbol
Epb41l4aprovided by MGI
Official Full Name
erythrocyte membrane protein band 4.1 like 4aprovided by MGI
Primary source
MGI:MGI:103007
See related
Ensembl:ENSMUSG00000024376 AllianceGenome:MGI:103007
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NBL4; Epb4.1l4; Epb4.1l4a
Summary
Predicted to enable cytoskeletal protein binding activity. Predicted to be involved in actomyosin structure organization. Predicted to be located in cytoplasm. Predicted to be active in cytoskeleton. Is expressed in several structures, including alimentary system; female reproductive system; nervous system; sensory organ; and skin. Orthologous to human EPB41L4A (erythrocyte membrane protein band 4.1 like 4A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 2.9), whole brain E14.5 (RPKM 2.8) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Epb41l4a in Genome Data Viewer
Location:
18 B1; 18 18.19 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (33929380..34143678, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (33796327..34007484, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 54016 Neighboring gene STARR-seq mESC enhancer starr_44172 Neighboring gene erythrocyte membrane protein band 4.1 like 4a, opposite strand Neighboring gene predicted gene, 23639 Neighboring gene STARR-seq mESC enhancer starr_44177 Neighboring gene STARR-seq mESC enhancer starr_44180 Neighboring gene STARR-seq mESC enhancer starr_44187 Neighboring gene predicted gene, 22788 Neighboring gene predicted gene, 50265 Neighboring gene peptidylprolyl isomerase A pseudogene 18_318.1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of human NBL4, a gene involved in the beta-catenin/tcf signaling pathway. Ishiguro H, et al. Jpn J Cancer Res, 2000 Jun. PMID 10874211, Free PMC Article
  2. Structural diversity of band 4.1 superfamily members. Takeuchi K, et al. J Cell Sci, 1994 Jul. PMID 7983158
  3. Discovery and validation of genes driving drug-intake and related behavioral traits in mice. Roy TA, et al. Genes Brain Behav, 2024 Jan 2. PMID 38164795, Free PMC Article
  4. Effects of glucokinase haploinsufficiency on the pancreatic β-cell mass and function of long-term high-fat, high-sucrose diet-fed mice. Shigesawa I, et al. J Diabetes Investig, 2024 Sep 21. PMID 39305123
  5. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actomyosin structure organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
band 4.1-like protein 4A
Names
erythrocyte protein band 4.1-like 4
erythrocyte protein band 4.1-like 4a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013512.2 → NP_038540.2  band 4.1-like protein 4A

    See identical proteins and their annotated locations for NP_038540.2

    Status: VALIDATED

    Source sequence(s)
    AC150277, AK140485, BE631863, CB246498, CX204315
    Consensus CDS
    CCDS29124.1
    UniProtKB/Swiss-Prot
    P52963, Q91VX6
    Related
    ENSMUSP00000025234.6, ENSMUST00000025234.7
    Conserved Domains (5) summary
    smart00295
    Location:13 → 211
    B41; Band 4.1 homologues
    cd13186
    Location:207 → 296
    FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
    pfam00373
    Location:105 → 211
    FERM_M; FERM central domain
    pfam08736
    Location:311 → 354
    FA; FERM adjacent (FA)
    pfam09379
    Location:15 → 80
    FERM_N; FERM N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    33929380..34143678 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525627.5 → XP_006525690.1  band 4.1-like protein 4A isoform X1

    Conserved Domains (3) summary
    smart00295
    Location:29 → 176
    B41; Band 4.1 homologues
    cd13186
    Location:172 → 261
    FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
    pfam08736
    Location:276 → 319
    FA; FERM adjacent (FA)

  2. XM_030250329.2 → XP_030106189.1  band 4.1-like protein 4A isoform X4

    Conserved Domains (3) summary
    smart00295
    Location:1 → 74
    B41; Band 4.1 homologues
    cd13186
    Location:70 → 159
    FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
    pfam08736
    Location:174 → 217
    FA; FERM adjacent (FA)

  3. XM_006525628.5 → XP_006525691.1  band 4.1-like protein 4A isoform X2

    Conserved Domains (3) summary
    smart00295
    Location:13 → 211
    B41; Band 4.1 homologues
    cd13186
    Location:207 → 296
    FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
    pfam08736
    Location:311 → 354
    FA; FERM adjacent (FA)

  4. XM_030250328.2 → XP_030106188.1  band 4.1-like protein 4A isoform X4

    Conserved Domains (3) summary
    smart00295
    Location:1 → 74
    B41; Band 4.1 homologues
    cd13186
    Location:70 → 159
    FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
    pfam08736
    Location:174 → 217
    FA; FERM adjacent (FA)

  5. XM_030250326.2 → XP_030106186.1  band 4.1-like protein 4A isoform X4

    Conserved Domains (3) summary
    smart00295
    Location:1 → 74
    B41; Band 4.1 homologues
    cd13186
    Location:70 → 159
    FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
    pfam08736
    Location:174 → 217
    FA; FERM adjacent (FA)

  6. XM_030250330.2 → XP_030106190.1  band 4.1-like protein 4A isoform X4

    Conserved Domains (3) summary
    smart00295
    Location:1 → 74
    B41; Band 4.1 homologues
    cd13186
    Location:70 → 159
    FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
    pfam08736
    Location:174 → 217
    FA; FERM adjacent (FA)

  7. XM_011246840.3 → XP_011245142.1  band 4.1-like protein 4A isoform X4

    See identical proteins and their annotated locations for XP_011245142.1

    Conserved Domains (3) summary
    smart00295
    Location:1 → 74
    B41; Band 4.1 homologues
    cd13186
    Location:70 → 159
    FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
    pfam08736
    Location:174 → 217
    FA; FERM adjacent (FA)

  8. XM_006525629.2 → XP_006525692.1  band 4.1-like protein 4A isoform X3

    Conserved Domains (3) summary
    smart00295
    Location:9 → 151
    B41; Band 4.1 homologues
    cd13186
    Location:147 → 236
    FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
    pfam08736
    Location:251 → 294
    FA; FERM adjacent (FA)

  9. XM_006525631.5 → XP_006525694.1  band 4.1-like protein 4A isoform X4

    See identical proteins and their annotated locations for XP_006525694.1

    Conserved Domains (3) summary
    smart00295
    Location:1 → 74
    B41; Band 4.1 homologues
    cd13186
    Location:70 → 159
    FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
    pfam08736
    Location:174 → 217
    FA; FERM adjacent (FA)

  10. XM_006525635.5 → XP_006525698.1  band 4.1-like protein 4A isoform X5

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52963.2 GenPept UniProtKB/Swiss-Prot:P52963

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