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PPP4R3C protein phosphatase 4 regulatory subunit 3C [ Homo sapiens (human) ]

Gene ID: 139420, updated on 5-Mar-2024

Summary

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Official Symbol
PPP4R3Cprovided by HGNC
Official Full Name
protein phosphatase 4 regulatory subunit 3Cprovided by HGNC
Primary source
HGNC:HGNC:33146
See related
Ensembl:ENSG00000224960 AllianceGenome:HGNC:33146
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
smk1; FLFL3P; SMEK3P; PPP4R3CP
Orthologs
all
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Genomic context

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Location:
Xp21.3
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (27460207..27463341, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (27050535..27053669, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (27478324..27481458, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373150 Neighboring gene AMZ2 pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 13349 Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:27480372-27481571 Neighboring gene PTP4A1 pseudogene 5 Neighboring gene NANOG hESC enhancer GRCh37_chrX:27488313-27488871 Neighboring gene DDB1 and CUL4 associated factor 8 like 2 Neighboring gene radixin pseudogene 2 Neighboring gene RDX pseudogene 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:27818821-27819333 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:27819334-27819845 Neighboring gene MAGE family member B18 pseudogene Neighboring gene MAGE family member B10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • FLJ32867

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein phosphatase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase 4 complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein PPP4R3C
Names
Putative SMEK homolog 3
SMEK homolog 3, suppressor of mek1 pseudogene
Serine/threonine-protein phosphatase 4 regulatory subunit 3C pseudogene
protein phosphatase 4 regulatory subunit 3C, pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207319.4 → NP_997202.3  protein PPP4R3C

    Status: VALIDATED

    Source sequence(s)
    AC006210
    Consensus CDS
    CCDS87732.1
    UniProtKB/Swiss-Prot
    A0A1B0GTN1, Q6ZMV5, Q96M31
    Related
    ENSP00000489770.1, ENST00000412172.4
    Conserved Domains (1) summary
    pfam04802
    Location:168 → 359
    SMK-1; Component of IIS longevity pathway SMK-1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    27460207..27463341 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    27050535..27053669 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZMV5.3 GenPept UniProtKB/Swiss-Prot:Q6ZMV5

Gene LinkOut

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Molecular Biology Databases
Research Materials
Miscellaneous