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MAGEB16 MAGE family member B16 [ Homo sapiens (human) ]

Gene ID: 139604, updated on 5-Mar-2024

Summary

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Official Symbol
MAGEB16provided by HGNC
Official Full Name
MAGE family member B16provided by HGNC
Primary source
HGNC:HGNC:21188
See related
Ensembl:ENSG00000189023 MIM:300762; AllianceGenome:HGNC:21188
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 2.3) See more
Orthologs
mouse all
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Genomic context

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Location:
Xp21.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (35798342..35803772)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (35393886..35399316)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (35816459..35821889)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene CDC42 binding protein kinase beta (DMPK-like) pseudogene Neighboring gene NFYC pseudogene 1 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chrX:35841387-35842135 Neighboring gene cilia and flagella associated protein 47 Neighboring gene RNA, U6 small nuclear 641, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:36216564-36217118 Neighboring gene high mobility group box 1 pseudogene 16

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Demethylation of CpG islands in the 5' upstream regions mediates the expression of the human testis-specific gene MAGEB16 and its mouse homolog Mageb16. Liu Y, et al. BMB Rep, 2014 Feb. PMID 24219866, Free PMC Article
  2. An overview of the MAGE gene family with the identification of all human members of the family. Chomez P, et al. Cancer Res, 2001 Jul 15. PMID 11454705
  3. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. Huttlin EL, et al. Cell, 2015 Jul 16. PMID 26186194, Free PMC Article
  5. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The testis-specific expression of MAGEB16 and Mageb16 is regulated by the methylation status of their promoter regions.
    Title: Demethylation of CpG islands in the 5' upstream regions mediates the expression of the human testis-specific gene MAGEB16 and its mouse homolog Mageb16.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
melanoma-associated antigen B16
Names
MAGE-B16 antigen
melanoma antigen family B, 16 (pseudogene)
melanoma antigen family B16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099921.2 → NP_001093391.1  melanoma-associated antigen B16 isoform 1

    See identical proteins and their annotated locations for NP_001093391.1

    Status: VALIDATED

    Source sequence(s)
    AL161722
    Consensus CDS
    CCDS43927.1
    UniProtKB/Swiss-Prot
    A2A368, A8MU30
    UniProtKB/TrEMBL
    A0A0A0MSA3
    Related
    ENSP00000382871.1, ENST00000399989.5
    Conserved Domains (2) summary
    pfam12440
    Location:5 → 90
    MAGE_N; Melanoma associated antigen family N terminal
    pfam01454
    Location:120 → 288
    MAGE; MAGE family

  2. NM_001370158.1 → NP_001357087.1  melanoma-associated antigen B16 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL161722
    Consensus CDS
    CCDS43927.1
    UniProtKB/Swiss-Prot
    A2A368, A8MU30
    UniProtKB/TrEMBL
    A0A0A0MSA3
    Related
    ENSP00000382870.1, ENST00000399988.6
    Conserved Domains (2) summary
    pfam12440
    Location:5 → 90
    MAGE_N; Melanoma associated antigen family N terminal
    pfam01454
    Location:120 → 288
    MAGE; MAGE family

  3. NM_001370159.1 → NP_001357088.1  melanoma-associated antigen B16 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL161722
    Consensus CDS
    CCDS43927.1
    UniProtKB/Swiss-Prot
    A2A368, A8MU30
    UniProtKB/TrEMBL
    A0A0A0MSA3
    Related
    ENSP00000382867.1, ENST00000399985.1
    Conserved Domains (2) summary
    pfam12440
    Location:5 → 90
    MAGE_N; Melanoma associated antigen family N terminal
    pfam01454
    Location:120 → 288
    MAGE; MAGE family

  4. NM_001426398.1 → NP_001413327.1  melanoma-associated antigen B16 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CP068255

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    35798342..35803772
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    35393886..35399316
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326484.1 → XP_054182459.1  melanoma-associated antigen B16 isoform X1

  2. XM_054326485.1 → XP_054182460.1  melanoma-associated antigen B16 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2A368.2 GenPept UniProtKB/Swiss-Prot:A2A368

Gene LinkOut

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