Wfdc18 WAP four-disulfide core domain 18 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wfdc18provided by MGI
Official Full Name: WAP four-disulfide core domain 18provided by MGI
Primary source: MGI:MGI:107506
See related: Ensembl:ENSMUSG00000000983 AllianceGenome:MGI:107506
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Expi; Kal1; WDNM1
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in antibacterial humoral response and innate immune response. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in mammary gland. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in mammary gland adult (RPKM 18.3), thymus adult (RPKM 11.0) and 4 other tissues See more
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Genomic context

Location:: 11 C; 11 51.23 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (83599830..83602186)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (83709004..83711360)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

General gene information

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Markers

D10M11Mit119 (e-PCR)
- UniSTS:126308

D11Mit119 (e-PCR), detects polymorphism
- UniSTS:126308

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in antibacterial humoral response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: WAP four-disulfide core domain protein 18

Names: Kallmann syndrome 1 sequence; extracellular peptidase inhibitor; extracellular proteinase inhibitor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007969.4 → NP_031995.3 WAP four-disulfide core domain protein 18 precursor

See identical proteins and their annotated locations for NP_031995.3

Status: VALIDATED

Source sequence(s)

EH099462, EH105860, EH109450

Consensus CDS

CCDS25175.1

UniProtKB/Swiss-Prot

P62810, Q91VQ6

UniProtKB/TrEMBL

Q3UMA2

Related

ENSMUSP00000001009.8, ENSMUST00000001009.14

Conserved Domains (1) summary

cd00199
Location:14 → 73

WAP; whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of ...