Igf2bp3 insulin-like growth factor 2 mRNA binding protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Igf2bp3provided by MGI
Official Full Name: insulin-like growth factor 2 mRNA binding protein 3provided by MGI
Primary source: MGI:MGI:1890359
See related: Ensembl:ENSMUSG00000029814 AllianceGenome:MGI:1890359
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IMP3; IMP-3; Koc13; mimp3; Neilsen; 2610101N11Rik
Summary: Predicted to enable N6-methyladenosine-containing RNA reader activity; mRNA 3'-UTR binding activity; and mRNA 5'-UTR binding activity. Predicted to be involved in CRD-mediated mRNA stabilization and nervous system development. Predicted to be located in P-body and cytoplasmic stress granule. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including central nervous system; early conceptus; gonad; liver; and sensory organ. Orthologous to human IGF2BP3 (insulin like growth factor 2 mRNA binding protein 3). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in CNS E11.5 (RPKM 14.8), testis adult (RPKM 10.2) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B2.3; 6 23.82 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (49062152..49200225, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (49085218..49215469, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IGF2BP3-stabilized CAMK1 regulates the mitochondrial dynamics of renal tubule to alleviate diabetic nephropathy.
Title: IGF2BP3-stabilized CAMK1 regulates the mitochondrial dynamics of renal tubule to alleviate diabetic nephropathy.
LINC00942 inhibits ferroptosis and induces the immunosuppression of regulatory T cells by recruiting IGF2BP3/SLC7A11 in hepatocellular carcinoma.
Title: LINC00942 inhibits ferroptosis and induces the immunosuppression of regulatory T cells by recruiting IGF2BP3/SLC7A11 in hepatocellular carcinoma.
IGF2BP3-mediated enhanced stability of MYLK represses MSC adipogenesis and alleviates obesity and insulin resistance in HFD mice.
Title: IGF2BP3-mediated enhanced stability of MYLK represses MSC adipogenesis and alleviates obesity and insulin resistance in HFD mice.
UBE2K regulated by IGF2BP3 promotes cell proliferation and stemness in pancreatic ductal adenocarcinoma.
Title: UBE2K regulated by IGF2BP3 promotes cell proliferation and stemness in pancreatic ductal adenocarcinoma.
Deletion of Insulin-like growth factor II mRNA-binding protein 3 participates in the pathogenesis of recurrent spontaneous abortion by inhibiting IL-10 secretion and inducing M1 polarization.
Title: Deletion of Insulin-like growth factor II mRNA-binding protein 3 participates in the pathogenesis of recurrent spontaneous abortion by inhibiting IL-10 secretion and inducing M1 polarization.
IMP3 promotes re-endothelialization after arterial injury via increasing stability of VEGF mRNAhv.
Title: IMP3 promotes re-endothelialization after arterial injury via increasing stability of VEGF mRNAhv.
The RNA-binding protein IGF2BP3 is critical for MLL-AF4-mediated leukemogenesis.
Title: The RNA-binding protein IGF2BP3 is critical for MLL-AF4-mediated leukemogenesis.
The germinal center reaction depends on RNA methylation and divergent functions of specific methyl readers.
Title: The germinal center reaction depends on RNA methylation and divergent functions of specific methyl readers.
Circular RNA_101237 mediates anoxia/reoxygenation injury by targeting let7a5p/IGF2BP3 in cardiomyocytes.
Title: Circular RNA_101237 mediates anoxia/reoxygenation injury by targeting let‑7a‑5p/IGF2BP3 in cardiomyocytes.
Lin28b and Igf2bp3 are at the center of a gene regulatory network that mediates the fetal-adult hematopoietic switch
Title: Enhancement of LIN28B-induced hematopoietic reprogramming by IGF2BP3.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU045931 (e-PCR)
- UniSTS:159499

RH125379 (e-PCR)
- UniSTS:162201

Igf2bp3 (e-PCR), detects polymorphism
- UniSTS:479167

NoName (e-PCR)
- UniSTS:224448

RH126325 (e-PCR)
- UniSTS:163033

RH124448 (e-PCR)
- UniSTS:161270

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N6-methyladenosine-containing RNA reader activity	ISO Inferred from Sequence Orthology more info
enables N6-methyladenosine-containing RNA reader activity	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA 5'-UTR binding	IEA Inferred from Electronic Annotation more info
enables mRNA 5'-UTR binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in CRD-mediated mRNA stabilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in CRD-mediated mRNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in CRD-mediated mRNA stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in P-body	ISO Inferred from Sequence Orthology more info
located_in P-body	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: insulin-like growth factor 2 mRNA-binding protein 3

Names: IGF-II mRNA-binding protein 3; IGF2 mRNA-binding protein 3; VICKZ family member 3; insulin-like growth factor 2, binding protein 3; mIMP-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023670.3 → NP_076159.3 insulin-like growth factor 2 mRNA-binding protein 3

See identical proteins and their annotated locations for NP_076159.3

Status: VALIDATED

Source sequence(s)

AK147140, BC045138, CB524241

Consensus CDS

CCDS39485.1

UniProtKB/Swiss-Prot

Q3UHZ6, Q8C2J9, Q9CPN8

Related

ENSMUSP00000031838.8, ENSMUST00000031838.9

Conserved Domains (4) summary

cd00105
Location:279 → 344

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:407 → 470

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

cd12630
Location:81 → 156

RRM2_IGF2BP3; RNA recognition motif 2 in vertebrate insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)

cl17169
Location:1 → 77

RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

49062152..49200225 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030255148.2 → XP_030111008.1 insulin-like growth factor 2 mRNA-binding protein 3 isoform X2

Conserved Domains (3) summary

cd00105
Location:16 → 81

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:144 → 207

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

pfam00013
Location:229 → 292

KH_1; KH domain
XM_006505517.4 → XP_006505580.1 insulin-like growth factor 2 mRNA-binding protein 3 isoform X1

Conserved Domains (5) summary

cd00105
Location:238 → 303

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:366 → 429

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

cd12630
Location:40 → 115

RRM2_IGF2BP3; RNA recognition motif 2 in vertebrate insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)

pfam00013
Location:451 → 514

KH_1; KH domain

cl17169
Location:16 → 36

RRM_SF; RNA recognition motif (RRM) superfamily
XM_006505519.4 → XP_006505582.1 insulin-like growth factor 2 mRNA-binding protein 3 isoform X2

Conserved Domains (3) summary

cd00105
Location:16 → 81

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:144 → 207

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

pfam00013
Location:229 → 292

KH_1; KH domain