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S100A16 S100 calcium binding protein A16 [ Homo sapiens (human) ]

Gene ID: 140576, updated on 5-Nov-2024

Summary

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Official Symbol
S100A16provided by HGNC
Official Full Name
S100 calcium binding protein A16provided by HGNC
Primary source
HGNC:HGNC:20441
See related
Ensembl:ENSG00000188643 MIM:617437; AllianceGenome:HGNC:20441
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AAG13; S100F; DT1P1A7
Summary
Enables calcium ion binding activity and protein homodimerization activity. Predicted to act upstream of or within response to calcium ion. Located in several cellular components, including cytosol; extracellular space; and nucleolus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in esophagus (RPKM 418.9), skin (RPKM 89.4) and 13 other tissues See more
Orthologs
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Genomic context

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See S100A16 in Genome Data Viewer
Location:
1q21.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (153606883..153613137, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (152744143..152750397, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (153579359..153585613, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928034 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:153521261-153521822 Neighboring gene Sharpr-MPRA regulatory region 14368 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:153522386-153522947 Neighboring gene S100 calcium binding protein A3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153536677-153537434 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153537435-153538192 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:153538345-153539544 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153539708-153540464 Neighboring gene S100 calcium binding protein A2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1749 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153546964-153547744 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153547745-153548525 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153550484-153551282 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153555559-153556483 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153577506-153578461 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:153580804-153582003 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:153588740-153589240 Neighboring gene S100 calcium binding protein A14 Neighboring gene S100 calcium binding protein A13 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153599403-153600228 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:153601055-153601878 Neighboring gene S100 calcium binding protein A1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Calbindin S100A16 Promotes Renal Cell Carcinoma Progression and Angiogenesis via the VEGF/VEGFR2 Signaling Pathway. Wang N, et al. Contrast Media Mol Imaging, 2022. PMID 36176934, Free PMC Article
  2. [S100 calcium binding protein A16 promotes fat synthesis through endoplasmic reticulum stress in HepG2 cells]. Kan JB, et al. Sheng Li Xue Bao, 2019 Apr 25. PMID 31008487
  3. S100A16 suppresses the growth and survival of leukaemia cells and correlates with relapse and relapse free survival in adults with Philadelphia chromosome-negative B-cell acute lymphoblastic leukaemia. Zhang J, et al. Br J Haematol, 2019 Jun. PMID 30916375
  4. Brain microvascular endothelial cell exosome-mediated S100A16 up-regulation confers small-cell lung cancer cell survival in brain. Xu ZH, et al. FASEB J, 2019 Feb. PMID 30183374
  5. S100A16 Regulates HeLa Cell through the Phosphatidylinositol 3 Kinase (PI3K)/AKT Signaling Pathway. Zhang H, et al. Med Sci Monit, 2020 Jan 2. PMID 31894756, Free PMC Article

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. S100A16 stabilizes the ITGA3-mediated ECM-receptor interaction pathway to drive the malignant properties of lung adenocarcinoma cells via binding MOV10.
    Title: S100A16 stabilizes the ITGA3‑mediated ECM‑receptor interaction pathway to drive the malignant properties of lung adenocarcinoma cells via binding MOV10.
  2. Resistance to gemcitabine is mediated by the circ_0036627/miR-145/S100A16 axis in pancreatic cancer.
    Title: Resistance to gemcitabine is mediated by the circ_0036627/miR-145/S100A16 axis in pancreatic cancer.
  3. S100A16 is a potential target for reshaping the tumor microenvironment in the hypoxic context of liver cancer.
    Title: S100A16 is a potential target for reshaping the tumor microenvironment in the hypoxic context of liver cancer.
  4. An Update on S100A16 in Human Cancer.
    Title: An Update on S100A16 in Human Cancer.
  5. S100 Calcium Binding Protein A16 Promotes Cell Proliferation by triggering LATS1 ubiquitin degradation mediated by CUL4A ligase to inhibit Hippo pathway in Glioma development.
    Title: S100 Calcium Binding Protein A16 Promotes Cell Proliferation by triggering LATS1 ubiquitin degradation mediated by CUL4A ligase to inhibit Hippo pathway in Glioma development.
  6. New progress with calcium-binding protein S100A16 in digestive system disease.
    Title: New progress with calcium-binding protein S100A16 in digestive system disease.
  7. Calbindin S100A16 Promotes Renal Cell Carcinoma Progression and Angiogenesis via the VEGF/VEGFR2 Signaling Pathway.
    Title: Calbindin S100A16 Promotes Renal Cell Carcinoma Progression and Angiogenesis via the VEGF/VEGFR2 Signaling Pathway.
  8. Downregulated Calcium-Binding Protein S100A16 and HSP27 in Placenta-Derived Multipotent Cells Induce Functional Astrocyte Differentiation.
    Title: Downregulated Calcium-Binding Protein S100A16 and HSP27 in Placenta-Derived Multipotent Cells Induce Functional Astrocyte Differentiation.
  9. The interaction of S100A16 and GRP78 actives endoplasmic reticulum stress-mediated through the IRE1alpha/XBP1 pathway in renal tubulointerstitial fibrosis.
    Title: The interaction of S100A16 and GRP78 actives endoplasmic reticulum stress-mediated through the IRE1α/XBP1 pathway in renal tubulointerstitial fibrosis.
  10. S100A16 promotes metastasis and progression of pancreatic cancer through FGF19-mediated AKT and ERK1/2 pathways.
    Title: S100A16 promotes metastasis and progression of pancreatic cancer through FGF19-mediated AKT and ERK1/2 pathways.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC17528

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in response to calcium ion IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
protein S100-A16
Names
aging-associated gene 13 protein
aging-associated protein 13
protein S100-F

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317007.1 → NP_001303936.1  protein S100-A16

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 all encode the same protein.
    Source sequence(s)
    AI673616, BC010541, BQ439720, HY178745
    Consensus CDS
    CCDS1045.1
    UniProtKB/Swiss-Prot
    A8K439, D3DV52, Q5RHS6, Q96FQ6
    Related
    ENSP00000357694.1, ENST00000368705.2
    Conserved Domains (1) summary
    cd05022
    Location:6 → 99
    S-100A13; S-100A13: S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, ...

  2. NM_001317008.2 → NP_001303937.1  protein S100-A16

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same protein.
    Source sequence(s)
    AI673616, BC010541, HY178745
    Consensus CDS
    CCDS1045.1
    UniProtKB/Swiss-Prot
    A8K439, D3DV52, Q5RHS6, Q96FQ6
    Related
    ENSP00000357693.1, ENST00000368704.5
    Conserved Domains (1) summary
    cd05022
    Location:6 → 99
    S-100A13; S-100A13: S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, ...

  3. NM_080388.3 → NP_525127.1  protein S100-A16

    See identical proteins and their annotated locations for NP_525127.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same protein.
    Source sequence(s)
    AI673616, BC010541, BM739127
    Consensus CDS
    CCDS1045.1
    UniProtKB/Swiss-Prot
    A8K439, D3DV52, Q5RHS6, Q96FQ6
    Related
    ENSP00000357695.3, ENST00000368706.9
    Conserved Domains (1) summary
    cd05022
    Location:6 → 99
    S-100A13; S-100A13: S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, ...

RNA

  1. NR_133645.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate first exon and an alternate splice junction compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AI673616, AW954845, BC010541

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    153606883..153613137 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047446559.1 → XP_047302515.1  protein S100-A16 isoform X1

    UniProtKB/Swiss-Prot
    A8K439, D3DV52, Q5RHS6, Q96FQ6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    152744143..152750397 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334493.1 → XP_054190468.1  protein S100-A16 isoform X1

    UniProtKB/Swiss-Prot
    A8K439, D3DV52, Q5RHS6, Q96FQ6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96FQ6.1 GenPept UniProtKB/Swiss-Prot:Q96FQ6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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