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CTCFL CCCTC-binding factor like [ Homo sapiens (human) ]

Gene ID: 140690, updated on 2-Nov-2024

Summary

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Official Symbol
CTCFLprovided by HGNC
Official Full Name
CCCTC-binding factor likeprovided by HGNC
Primary source
HGNC:HGNC:16234
See related
Ensembl:ENSG00000124092 MIM:607022; AllianceGenome:HGNC:16234
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT27; BORIS; CTCF-T; HMGB1L1; dJ579F20.2
Summary
CCCTC-binding factor (CTCF), an 11-zinc-finger factor involved in gene regulation, utilizes different zinc fingers to bind varying DNA target sites. CTCF forms methylation-sensitive insulators that regulate X-chromosome inactivation. This gene is a paralog of CTCF and appears to be expressed primarily in the cytoplasm of spermatocytes, unlike CTCF which is expressed primarily in the nucleus of somatic cells. CTCF and the protein encoded by this gene are normally expressed in a mutually exclusive pattern that correlates with resetting of methylation marks during male germ cell differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
Expression
Restricted expression toward testis (RPKM 3.5) See more
Orthologs
mouse all
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Genomic context

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See CTCFL in Genome Data Viewer
Location:
20q13.31
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (57495965..57525652, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (59273778..59303467, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (56071021..56100708, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372688 Neighboring gene Sharpr-MPRA regulatory region 5175 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:56039390-56040220 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56042501-56043002 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56045653-56046391 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56048063-56048564 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56048565-56049064 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18158 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56051358-56051858 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18159 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18160 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18161 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18162 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13063 Neighboring gene MPRA-validated peak4284 silencer Neighboring gene high mobility group box 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18163 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56074415-56074974 Neighboring gene MPRA-validated peak4285 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18164 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56098387-56099325 Neighboring gene uncharacterized LOC124904940 Neighboring gene uncharacterized LOC124904941

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. BORIS binding to the promoters of cancer testis antigens, MAGEA2, MAGEA3, and MAGEA4, is associated with their transcriptional activation in lung cancer. Bhan S, et al. Clin Cancer Res, 2011 Jul 1. PMID 21558405, Free PMC Article
  2. Brother of Regulator of Imprinted Sites (BORIS) suppresses apoptosis in colorectal cancer. Zhang Y, et al. Sci Rep, 2017 Jan 18. PMID 28098226, Free PMC Article
  3. Tomorrow's genome medicine in lung cancer. Wang DC, et al. Semin Cancer Biol, 2017 Feb. PMID 27840277
  4. A polymorphic minisatellite region of BORIS regulates gene expression and its rare variants correlate with lung cancer susceptibility. Yoon SL, et al. Exp Mol Med, 2016 Jul 15. PMID 27416782, Free PMC Article
  5. Brother of the regulator of the imprinted site (BORIS) variant subfamily 6 is involved in cervical cancer stemness and can be a target of immunotherapy. Asano T, et al. Oncotarget, 2016 Mar 8. PMID 26849232, Free PMC Article

See all (91) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BORIS/CTCFL-mediated chromatin accessibility alterations promote a pro-invasive transcriptional signature in melanoma cells.
    Title: BORIS/CTCFL-mediated chromatin accessibility alterations promote a pro-invasive transcriptional signature in melanoma cells.
  2. Association of mutation and expression of the brother of the regulator of imprinted sites (BORIS) gene with breast cancer progression.
    Title: Association of mutation and expression of the brother of the regulator of imprinted sites (BORIS) gene with breast cancer progression.
  3. BORIS variant SF2(C2/A4) promotes the malignant development of liver cancer by activating epithelial-mesenchymal transition and hepatic stellate cells.
    Title: BORIS variant SF2(C2/A4) promotes the malignant development of liver cancer by activating epithelial-mesenchymal transition and hepatic stellate cells.
  4. Exploring the cancer-testis antigen BORIS to design a novel multi-epitope vaccine against breast cancer based on immunoinformatics approaches.
    Title: Exploring the cancer-testis antigen BORIS to design a novel multi-epitope vaccine against breast cancer based on immunoinformatics approaches.
  5. Downregulation of BORIS/CTCFL leads to ROS-dependent cellular senescence and drug sensitivity in MYCN-amplified neuroblastoma.
    Title: Downregulation of BORIS/CTCFL leads to ROS-dependent cellular senescence and drug sensitivity in MYCN-amplified neuroblastoma.
  6. CTCFL regulates the PI3K-Akt pathway and it is a target for personalized ovarian cancer therapy.
    Title: CTCFL regulates the PI3K-Akt pathway and it is a target for personalized ovarian cancer therapy.
  7. Transcription Factor CTCFL Promotes Cell Proliferation, Migration, and Invasion in Gastric Cancer via Activating DPPA2.
    Title: Transcription Factor CTCFL Promotes Cell Proliferation, Migration, and Invasion in Gastric Cancer via Activating DPPA2.
  8. CTCFL expression is associated with cerebral vascular abnormalities.
    Title: CTCFL expression is associated with cerebral vascular abnormalities.
  9. BORIS/CTCFL expression activates the TGFbeta signaling cascade and induces Drp1 mediated mitochondrial fission in neuroblastoma.
    Title: BORIS/CTCFL expression activates the TGFβ signaling cascade and induces Drp1 mediated mitochondrial fission in neuroblastoma.
  10. Pericentromeric noncoding RNA changes DNA binding of CTCF and inflammatory gene expression in senescence and cancer.
    Title: Pericentromeric noncoding RNA changes DNA binding of CTCF and inflammatory gene expression in senescence and cancer.
Submit: New GeneRIF Correction See all GeneRIFs (71)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines.
EBI GWAS Catalog
Genome-wide association of lipid-lowering response to statins in combined study populations.
EBI GWAS Catalog
Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC163358, MGC169105, MGC169106

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin insulator sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in establishment of protein localization to chromatin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in genomic imprinting ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription initiation-coupled chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nuclear body IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
transcriptional repressor CTCFL
Names
BORIS-like protein
brother of the regulator of imprinted sites
cancer/testis antigen 27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001269040.2 → NP_001255969.1  transcriptional repressor CTCFL isoform 1

    See identical proteins and their annotated locations for NP_001255969.1

    Status: REVIEWED

    Source sequence(s)
    AL035541, AL160176
    Consensus CDS
    CCDS13459.1
    UniProtKB/Swiss-Prot
    A0S6W1, A1L4C6, A6XGL8, A6XGM2, A6XGM3, A6XGM8, A6XGN0, A6XGN1, A6XGN2, A6XGN3, A6XGN4, E7EQ27, E7EUE3, E9PBA9, Q5JUG4, Q8NI51, Q9BZ30, Q9NQJ3
    UniProtKB/TrEMBL
    B2RA05
    Related
    ENSP00000360239.2, ENST00000371196.6
    Conserved Domains (3) summary
    COG5048
    Location:259 → 403
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:344 → 364
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd20908
    Location:392 → 432
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  2. NM_001269041.2 → NP_001255970.1  transcriptional repressor CTCFL isoform 1

    See identical proteins and their annotated locations for NP_001255970.1

    Status: REVIEWED

    Source sequence(s)
    AL035541, AL160176
    Consensus CDS
    CCDS13459.1
    UniProtKB/Swiss-Prot
    A0S6W1, A1L4C6, A6XGL8, A6XGM2, A6XGM3, A6XGM8, A6XGN0, A6XGN1, A6XGN2, A6XGN3, A6XGN4, E7EQ27, E7EUE3, E9PBA9, Q5JUG4, Q8NI51, Q9BZ30, Q9NQJ3
    UniProtKB/TrEMBL
    B2RA05
    Related
    ENSP00000476783.1, ENST00000608263.5
    Conserved Domains (3) summary
    COG5048
    Location:259 → 403
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:344 → 364
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd20908
    Location:392 → 432
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  3. NM_001269042.2 → NP_001255971.1  transcriptional repressor CTCFL isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL035541, AL160176
    UniProtKB/TrEMBL
    B2RA05
    Conserved Domains (3) summary
    COG5048
    Location:259 → 403
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:344 → 364
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd20908
    Location:392 → 432
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  4. NM_001269043.2 → NP_001255972.1  transcriptional repressor CTCFL isoform 3

    See identical proteins and their annotated locations for NP_001255972.1

    Status: REVIEWED

    Source sequence(s)
    AL035541, AL160176
    Consensus CDS
    CCDS58780.1
    UniProtKB/TrEMBL
    B2RA05
    Related
    ENSP00000415579.2, ENST00000423479.7
    Conserved Domains (3) summary
    COG5048
    Location:259 → 403
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:344 → 364
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:385 → 409
    zf-H2C2_2; Zinc-finger double domain

  5. NM_001269044.3 → NP_001255973.1  transcriptional repressor CTCFL isoform 4

    See identical proteins and their annotated locations for NP_001255973.1

    Status: REVIEWED

    Source sequence(s)
    AL035541, AL160176
    Consensus CDS
    CCDS58781.1
    UniProtKB/TrEMBL
    B2RA05
    Related
    ENSP00000477488.1, ENST00000608440.5
    Conserved Domains (3) summary
    COG5048
    Location:259 → 403
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:344 → 364
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd20908
    Location:392 → 432
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  6. NM_001269045.2 → NP_001255974.1  transcriptional repressor CTCFL isoform 5

    See identical proteins and their annotated locations for NP_001255974.1

    Status: REVIEWED

    Source sequence(s)
    AL035541, AL160176
    Consensus CDS
    CCDS68164.1
    UniProtKB/TrEMBL
    A6XGM9, V9GY73
    Related
    ENSP00000476458.1, ENST00000608425.5
    Conserved Domains (3) summary
    COG5048
    Location:259 → 403
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:344 → 364
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:385 → 409
    zf-H2C2_2; Zinc-finger double domain

  7. NM_001269046.2 → NP_001255975.1  transcriptional repressor CTCFL isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL035541, AL160176
    Consensus CDS
    CCDS58779.1
    UniProtKB/TrEMBL
    B2RA05
    Related
    ENSP00000415329.2, ENST00000429804.7
    Conserved Domains (3) summary
    COG5048
    Location:259 → 443
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:259 → 279
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:357 → 378
    zf-H2C2_2; Zinc-finger double domain

  8. NM_001269047.2 → NP_001255976.1  transcriptional repressor CTCFL isoform 7

    See identical proteins and their annotated locations for NP_001255976.1

    Status: REVIEWED

    Source sequence(s)
    AL035541, AL160176
    Consensus CDS
    CCDS58782.1
    UniProtKB/TrEMBL
    A6XGM9
    Related
    ENSP00000399061.2, ENST00000422869.6
    Conserved Domains (3) summary
    COG5048
    Location:259 → 403
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:344 → 364
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:385 → 409
    zf-H2C2_2; Zinc-finger double domain

  9. NM_001269048.3 → NP_001255977.1  transcriptional repressor CTCFL isoform 8

    See identical proteins and their annotated locations for NP_001255977.1

    Status: REVIEWED

    Source sequence(s)
    AL035541, AL160176
    Consensus CDS
    CCDS58778.1
    UniProtKB/Swiss-Prot
    Q8NI51
    Related
    ENSP00000409344.2, ENST00000432255.6
    Conserved Domains (3) summary
    COG5048
    Location:259 → 413
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:259 → 279
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:300 → 324
    zf-H2C2_2; Zinc-finger double domain

  10. NM_001269049.2 → NP_001255978.1  transcriptional repressor CTCFL isoform 9

    See identical proteins and their annotated locations for NP_001255978.1

    Status: REVIEWED

    Source sequence(s)
    AL035541, AL160176
    Consensus CDS
    CCDS68162.1
    UniProtKB/Swiss-Prot
    Q8NI51
    Related
    ENSP00000392034.3, ENST00000433949.7
    Conserved Domains (3) summary
    COG5048
    Location:54 → 198
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:139 → 159
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:180 → 204
    zf-H2C2_2; Zinc-finger double domain

  11. NM_001269050.3 → NP_001255979.1  transcriptional repressor CTCFL isoform 10

    See identical proteins and their annotated locations for NP_001255979.1

    Status: REVIEWED

    Source sequence(s)
    AL035541, AL160176
    Consensus CDS
    CCDS58777.1
    UniProtKB/Swiss-Prot
    Q8NI51
    Related
    ENSP00000439998.1, ENST00000539382.5
    Conserved Domains (3) summary
    COG5048
    Location:54 → 198
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:139 → 159
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:180 → 204
    zf-H2C2_2; Zinc-finger double domain

  12. NM_001269051.2 → NP_001255980.1  transcriptional repressor CTCFL isoform 11

    See identical proteins and their annotated locations for NP_001255980.1

    Status: REVIEWED

    Source sequence(s)
    AL035541, AL160176
    Consensus CDS
    CCDS68163.1
    UniProtKB/TrEMBL
    A6XGM0, V9GYX4
    Related
    ENSP00000476577.1, ENST00000481655.2
    Conserved Domains (2) summary
    sd00017
    Location:259 → 279
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:271 → 296
    zf-H2C2_2; Zinc-finger double domain

  13. NM_001269052.3 → NP_001255981.1  transcriptional repressor CTCFL isoform 11

    See identical proteins and their annotated locations for NP_001255981.1

    Status: REVIEWED

    Source sequence(s)
    AL035541, AL160176
    Consensus CDS
    CCDS68163.1
    UniProtKB/TrEMBL
    A6XGM0, V9GYX4
    Related
    ENSP00000477165.1, ENST00000608158.5
    Conserved Domains (2) summary
    sd00017
    Location:259 → 279
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:271 → 296
    zf-H2C2_2; Zinc-finger double domain

  14. NM_001269054.2 → NP_001255983.1  transcriptional repressor CTCFL isoform 12

    See identical proteins and their annotated locations for NP_001255983.1

    Status: REVIEWED

    Source sequence(s)
    AL035541, AL160176
    Consensus CDS
    CCDS58776.1
    UniProtKB/Swiss-Prot
    Q8NI51
    Related
    ENSP00000437999.1, ENST00000502686.6
    Conserved Domains (3) summary
    COG5048
    Location:3 → 141
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:82 → 102
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:123 → 147
    zf-H2C2_2; Zinc-finger double domain

  15. NM_001269055.3 → NP_001255984.1  transcriptional repressor CTCFL isoform 13

    See identical proteins and their annotated locations for NP_001255984.1

    Status: REVIEWED

    Source sequence(s)
    AL035541, AL160176
    Consensus CDS
    CCDS68161.1
    UniProtKB/Swiss-Prot
    Q8NI51
    Related
    ENSP00000476718.1, ENST00000608903.5
    Conserved Domains (3) summary
    COG5048
    Location:3 → 141
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:82 → 102
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:123 → 147
    zf-H2C2_2; Zinc-finger double domain

  16. NM_001386993.1 → NP_001373922.1  transcriptional repressor CTCFL isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL035541, AL160176
    Consensus CDS
    CCDS13459.1
    UniProtKB/Swiss-Prot
    A0S6W1, A1L4C6, A6XGL8, A6XGM2, A6XGM3, A6XGM8, A6XGN0, A6XGN1, A6XGN2, A6XGN3, A6XGN4, E7EQ27, E7EUE3, E9PBA9, Q5JUG4, Q8NI51, Q9BZ30, Q9NQJ3
    UniProtKB/TrEMBL
    B2RA05
    Related
    ENSP00000243914.3, ENST00000243914.8
    Conserved Domains (3) summary
    COG5048
    Location:259 → 403
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:344 → 364
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd20908
    Location:392 → 432
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  17. NM_001386994.1 → NP_001373923.1  transcriptional repressor CTCFL isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL035541, AL160176
    UniProtKB/TrEMBL
    B2RA05
    Conserved Domains (3) summary
    COG5048
    Location:259 → 403
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:344 → 364
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd20908
    Location:392 → 432
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  18. NM_001386995.1 → NP_001373924.1  transcriptional repressor CTCFL isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL035541, AL160176
    UniProtKB/TrEMBL
    B2RA05
    Conserved Domains (3) summary
    COG5048
    Location:259 → 403
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:344 → 364
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd20908
    Location:392 → 432
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  19. NM_001386996.1 → NP_001373925.1  transcriptional repressor CTCFL isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL035541, AL160176
    Consensus CDS
    CCDS68163.1
    UniProtKB/TrEMBL
    A6XGM0, V9GYX4
    Conserved Domains (2) summary
    sd00017
    Location:259 → 279
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:271 → 296
    zf-H2C2_2; Zinc-finger double domain

  20. NM_001386997.1 → NP_001373926.1  transcriptional repressor CTCFL isoform 14

    Status: REVIEWED

    Source sequence(s)
    AL035541, AL160176
    UniProtKB/TrEMBL
    B2RA05
    Conserved Domains (3) summary
    COG5048
    Location:259 → 443
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:259 → 279
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13909
    Location:436 → 460
    zf-H2C2_5; C2H2-type zinc-finger domain

  21. NM_080618.4 → NP_542185.2  transcriptional repressor CTCFL isoform 1

    See identical proteins and their annotated locations for NP_542185.2

    Status: REVIEWED

    Source sequence(s)
    AL035541, AL160176
    Consensus CDS
    CCDS13459.1
    UniProtKB/Swiss-Prot
    A0S6W1, A1L4C6, A6XGL8, A6XGM2, A6XGM3, A6XGM8, A6XGN0, A6XGN1, A6XGN2, A6XGN3, A6XGN4, E7EQ27, E7EUE3, E9PBA9, Q5JUG4, Q8NI51, Q9BZ30, Q9NQJ3
    UniProtKB/TrEMBL
    B2RA05
    Related
    ENSP00000476398.1, ENST00000609232.5
    Conserved Domains (3) summary
    COG5048
    Location:259 → 403
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:344 → 364
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd20908
    Location:392 → 432
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

RNA

  1. NR_072975.3 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL035541, AL160176
    Related
    ENST00000426658.6

  2. NR_170377.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL035541, AL160176
    Related
    ENST00000422109.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    57495965..57525652 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    59273778..59303467 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NI51.2 GenPept UniProtKB/Swiss-Prot:Q8NI51

Gene LinkOut

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