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SAMD10 sterile alpha motif domain containing 10 [ Homo sapiens (human) ]

Gene ID: 140700, updated on 2-Nov-2024

Summary

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Official Symbol
SAMD10provided by HGNC
Official Full Name
sterile alpha motif domain containing 10provided by HGNC
Primary source
HGNC:HGNC:16129
See related
Ensembl:ENSG00000130590 AllianceGenome:HGNC:16129
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
dJ591C20; C20orf136; dJ591C20.7
Summary
Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be active in cytoplasmic side of plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in lymph node (RPKM 2.3), stomach (RPKM 1.9) and 24 other tissues See more
Orthologs
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Genomic context

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See SAMD10 in Genome Data Viewer
Location:
20q13.33
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (63974116..63980144, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (65793877..65799906, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (62605469..62610995, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62573671-62574384 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62574385-62575096 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18255 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62580108-62580646 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62580647-62581185 Neighboring gene uridine-cytidine kinase 1 like 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62581186-62581724 Neighboring gene microRNA 647 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13192 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13193 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13194 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18258 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62587955-62588842 Neighboring gene UCKL1 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62588843-62589728 Neighboring gene zinc finger protein 512B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62599635-62600172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62600173-62600708 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13196 Neighboring gene Sharpr-MPRA regulatory region 2003 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62610429-62610944 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18259 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13198 Neighboring gene pre-mRNA processing factor 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62631004-62631506 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:62636447-62636619 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:62642795-62643994 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:62648052-62649251 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18260 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62667815-62668408 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62668409-62669002 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13199 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13200 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13201 Neighboring gene chromosome 20 open reading frame 204

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Eeles RA, et al. Nat Genet, 2013 Apr. PMID 23535732, Free PMC Article
  2. The DNA sequence and comparative analysis of human chromosome 20. Deloukas P, et al. Nature, 2001 Dec 20-27. PMID 11780052
  3. Transcriptome analysis of human gastric cancer. Oh JH, et al. Mamm Genome, 2005 Dec. PMID 16341674
  4. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. Capalbo L, et al. Nat Commun, 2019 Oct 4. PMID 31586073, Free PMC Article
  5. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sterile alpha motif domain-containing protein 10
Names
D930033N23Rik
SAM domain-containing protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080621.5 → NP_542188.1  sterile alpha motif domain-containing protein 10

    See identical proteins and their annotated locations for NP_542188.1

    Status: VALIDATED

    Source sequence(s)
    BC067362, BM839907
    Consensus CDS
    CCDS13549.1
    UniProtKB/Swiss-Prot
    Q9BYL1
    Related
    ENSP00000358902.3, ENST00000369886.8
    Conserved Domains (1) summary
    cd09510
    Location:113 → 187
    SAM_aveugle-like; SAM domain of aveugle-like subfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    63974116..63980144 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528565.3 → XP_011526867.2  sterile alpha motif domain-containing protein 10 isoform X1

  2. XM_006723705.4 → XP_006723768.1  sterile alpha motif domain-containing protein 10 isoform X3

    Conserved Domains (2) summary
    cd09510
    Location:119 → 193
    SAM_aveugle-like; SAM domain of aveugle-like subfamily
    smart00454
    Location:121 → 188
    SAM; Sterile alpha motif

  3. XM_005260199.5 → XP_005260256.1  sterile alpha motif domain-containing protein 10 isoform X2

    Conserved Domains (2) summary
    cd09510
    Location:152 → 226
    SAM_aveugle-like; SAM domain of aveugle-like subfamily
    smart00454
    Location:154 → 221
    SAM; Sterile alpha motif

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    65793877..65799906 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323004.1 → XP_054178979.1  sterile alpha motif domain-containing protein 10 isoform X1

  2. XM_054323005.1 → XP_054178980.1  sterile alpha motif domain-containing protein 10 isoform X2

  3. XM_054323007.1 → XP_054178982.1  sterile alpha motif domain-containing protein 10 isoform X4

    UniProtKB/Swiss-Prot
    Q9BYL1

  4. XM_054323006.1 → XP_054178981.1  sterile alpha motif domain-containing protein 10 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BYL1.1 GenPept UniProtKB/Swiss-Prot:Q9BYL1

Gene LinkOut

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