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Cacng6 calcium voltage-gated channel auxiliary subunit gamma 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 140727, updated on 17-Aug-2024

Summary

Official Symbol
Cacng6provided by RGD
Official Full Name
calcium voltage-gated channel auxiliary subunit gamma 6provided by RGD
Primary source
RGD:628806
See related
EnsemblRapid:ENSRNOG00000063051 AllianceGenome:RGD:628806
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable calcium channel regulator activity. Predicted to be involved in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel. Predicted to be part of L-type voltage-gated calcium channel complex. Human ortholog(s) of this gene implicated in aspirin-induced respiratory disease. Orthologous to human CACNG6 (calcium voltage-gated channel auxiliary subunit gamma 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 160.4) and Heart (RPKM 25.5) See more
Orthologs
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Genomic context

See Cacng6 in Genome Data Viewer
Location:
1q12
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (74648342..74663351, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (65732910..65747377, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (64307684..64322124, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene T cell-interacting, activating receptor on myeloid cells 1 Neighboring gene V-set and transmembrane domain containing 1 Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 8 Neighboring gene microRNA 935 Neighboring gene uncharacterized LOC103691003 Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 7

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables calcium channel regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of L-type voltage-gated calcium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of L-type voltage-gated calcium channel complex ISO
Inferred from Sequence Orthology
more info
 
part_of L-type voltage-gated calcium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
voltage-dependent calcium channel gamma-6 subunit
Names
calcium channel, voltage-dependent, gamma subunit 6
neuronal voltage-gated calcium channel gamma-6 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080694.2NP_542425.1  voltage-dependent calcium channel gamma-6 subunit

    See identical proteins and their annotated locations for NP_542425.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q8VHW6, Q8VHW7
    UniProtKB/TrEMBL
    A6KS37
    Related
    ENSRNOP00000092698.2, ENSRNOT00000106854.2
    Conserved Domains (1) summary
    cl21598
    Location:47223
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    74648342..74663351 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008758749.3XP_008756971.1  voltage-dependent calcium channel gamma-6 subunit isoform X1

    See identical proteins and their annotated locations for XP_008756971.1

    UniProtKB/TrEMBL
    A6KS36
    Related
    ENSRNOP00000095459.2, ENSRNOT00000111328.2
    Conserved Domains (1) summary
    cl21598
    Location:47141
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family