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Psmc3ip PSMC3 interacting protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 140938, updated on 2-Nov-2024

Summary

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Official Symbol
Psmc3ipprovided by RGD
Official Full Name
PSMC3 interacting proteinprovided by RGD
Primary source
RGD:621885
See related
EnsemblRapid:ENSRNOG00000020022 AllianceGenome:RGD:621885
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gt198; Tbpip
Summary
Enables DNA binding domain binding activity; nuclear receptor binding activity; and nuclear receptor coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of DNA recombinase auxiliary factor complex. Predicted to be active in condensed nuclear chromosome. Human ortholog(s) of this gene implicated in ovarian dysgenesis 3. Orthologous to human PSMC3IP (PSMC3 interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 105.9), Thymus (RPKM 38.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Psmc3ip in Genome Data Viewer
Location:
10q31
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (86524546..86527764, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (86024281..86027928, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (89002109..89006075, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene hydroxysteroid (17-beta) dehydrogenase 1 Neighboring gene Coenzyme A synthase Neighboring gene MAX dimerization protein MLX Neighboring gene uncharacterized LOC134480875 Neighboring gene reticulophagy regulator family member 3 Neighboring gene tubulin, gamma 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. XX ovarian dysgenesis is caused by a PSMC3IP/HOP2 mutation that abolishes coactivation of estrogen-driven transcription. Zangen D, et al. Am J Hum Genet, 2011 Oct 7. PMID 21963259, Free PMC Article
  2. Identification and characterization of a tissue-specific coactivator, GT198, that interacts with the DNA-binding domains of nuclear receptors. Ko L, et al. Mol Cell Biol, 2002 Jan. PMID 11739747, Free PMC Article
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding domain binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear androgen receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclear estrogen receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclear glucocorticoid receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclear receptor coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclear receptor coactivator activity IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables nuclear thyroid hormone receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-containing complex binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables recombinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in homologous chromosome pairing at meiosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in homologous chromosome pairing at meiosis IEA
Inferred from Electronic Annotation
more info
  
involved_in homologous chromosome pairing at meiosis ISO
Inferred from Sequence Orthology
more info
  
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic joint molecule formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in meiotic strand invasion involved in reciprocal meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein-containing complex assembly TAS
Traceable Author Statement
more info
 PubMed 
involved_in reciprocal meiotic recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in reciprocal meiotic recombination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of DNA recombinase auxiliary factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in condensed nuclear chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
homologous-pairing protein 2 homolog
Names
nuclear receptor coactivator GT198
proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein
proteasome 26S ATPase subunit 3-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134458.2 → NP_604453.2  homologous-pairing protein 2 homolog

    Status: VALIDATED

    Source sequence(s)
    AF352812, CK840952
    UniProtKB/Swiss-Prot
    Q91ZY6
    UniProtKB/TrEMBL
    A6HJ83, G3V8N3
    Related
    ENSRNOP00000027159.4, ENSRNOT00000027159.8
    Conserved Domains (2) summary
    pfam07106
    Location:12 → 74
    TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
    pfam18517
    Location:154 → 210
    LZ3wCH; Leucine zipper with capping helix domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    86524546..86527764 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247249.5 → XP_006247311.1  homologous-pairing protein 2 homolog isoform X1

    UniProtKB/TrEMBL
    A6HJ83, G3V8N3
    Conserved Domains (1) summary
    pfam07106
    Location:16 → 179
    TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91ZY6.1 GenPept UniProtKB/Swiss-Prot:Q91ZY6

Gene LinkOut

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