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Arf3 ADP-ribosylation factor 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 140940, updated on 17-Aug-2024

Summary

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Symbol
Arf3provided by RGD
Full Name
ADP-ribosylation factor 3provided by RGD
Primary source
RGD:621273
See related
EnsemblRapid:ENSRNOG00000054775 AllianceGenome:RGD:621273
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ac1-253
Summary
Predicted to enable GTP binding activity. Predicted to be involved in intracellular protein transport and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to be located in Golgi apparatus and exocytic vesicle. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human ARF3 (ADP ribosylation factor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 1131.6), Adrenal (RPKM 288.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q36
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (131765039..131792075, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (129886082..129912022, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (140412463..140438751, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene tubulin, alpha 1C Neighboring gene uncharacterized LOC103692978 Neighboring gene coiled-coil domain containing 65 Neighboring gene FKBP prolyl isomerase 11 Neighboring gene transfer RNA lysine (anticodon UUU) 3 Neighboring gene Wnt family member 10B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Interspecies relationships among ADP-ribosylation factors (ARFs): evidence of evolutionary pressure to maintain individual identities. Price SR, et al. Mol Cell Biochem, 1996 Jun 7. PMID 8813705
  2. GGA3 mediates TrkA endocytic recycling to promote sustained Akt phosphorylation and cell survival. Li X, et al. Mol Biol Cell, 2015 Dec 1. PMID 26446845, Free PMC Article
  3. WLS retrograde transport to the endoplasmic reticulum during Wnt secretion. Yu J, et al. Dev Cell, 2014 May 12. PMID 24768165
  4. Structure and intracellular localization of mouse ADP-ribosylation factors type 1 to type 6 (ARF1-ARF6). Hosaka M, et al. J Biochem, 1996 Oct. PMID 8947846
  5. Use of fluorescence-activated vesicle sorting for isolation of Naked2-associated, basolaterally targeted exocytic vesicles for proteomics analysis. Cao Z, et al. Mol Cell Proteomics, 2008 Sep. PMID 18504258, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ADP-ribosylation factor 3
Names
liver regeneration-related protein LRRG202

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080904.3 → NP_543180.1  ADP-ribosylation factor 3

    See identical proteins and their annotated locations for NP_543180.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    P61206
    UniProtKB/TrEMBL
    A0A8I5ZKF2, A6KCA5
    Related
    ENSRNOP00000069538.1, ENSRNOT00000077884.3
    Conserved Domains (1) summary
    cl38936
    Location:5 → 179
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    131765039..131792075 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017594635.3 → XP_017450124.1  ADP-ribosylation factor 3 isoform X1

    UniProtKB/Swiss-Prot
    P61206
    UniProtKB/TrEMBL
    A0A8I5ZKF2, A6KCA5
    Conserved Domains (1) summary
    cl38936
    Location:5 → 179
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. XM_017594636.3 → XP_017450125.1  ADP-ribosylation factor 3 isoform X1

    UniProtKB/Swiss-Prot
    P61206
    UniProtKB/TrEMBL
    A0A8I5ZKF2, A6KCA5
    Conserved Domains (1) summary
    cl38936
    Location:5 → 179
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RNA

  1. XR_010052929.1 RNA Sequence

  2. XR_010052930.1 RNA Sequence

  3. XR_010052931.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61206.2 GenPept UniProtKB/Swiss-Prot:P61206

Gene LinkOut

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