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Paics phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase [ Rattus norvegicus (Norway rat) ]

Gene ID: 140946, updated on 2-Nov-2024

Summary

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Symbol
Paicsprovided by RGD
Full Name
phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthaseprovided by RGD
Primary source
RGD:620066
See related
EnsemblRapid:ENSRNOG00000002101 AllianceGenome:RGD:620066
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Airc; Ade2h1
Summary
Predicted to enable identical protein binding activity; phosphoribosylaminoimidazole carboxylase activity; and phosphoribosylaminoimidazolesuccinocarboxamide synthase activity. Involved in G1/S transition of mitotic cell cycle. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human PAICS (phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 540.1), Adrenal (RPKM 531.0) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Paics in Genome Data Viewer
Location:
14p11
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (31553355..31586843, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (31199086..31232731, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (33563884..33580944, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096735 Neighboring gene uncharacterized LOC120096737 Neighboring gene ADP-ribosylation factor like GTPase 9 Neighboring gene signal recognition particle 72 Neighboring gene phosphoribosyl pyrophosphate amidotransferase Neighboring gene aminoadipate-semialdehyde dehydrogenase Neighboring gene uncharacterized LOC120096736 Neighboring gene capping protein inhibiting regulator of actin dynamics

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Rat genomic structure of amidophosphoribosyltransferase, cDNA sequence of aminoimidazole ribonucleotide carboxylase, and cell cycle-dependent expression of these two physically linked genes. Iwahana H, et al. Biochim Biophys Acta, 1995 Apr 26. PMID 7742366
  2. Nucleotide sequence of a nearly full-length cDNA coding for pepsinogen of rat gastric mucosa. Ichihara Y, et al. Eur J Biochem, 1986 Nov 17. PMID 3780741
  3. Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches. Ikeda M, et al. Biol Psychiatry, 2010 Feb 1. PMID 19850283
  4. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article
  5. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Buschow SI, et al. Immunol Cell Biol, 2010 Nov-Dec. PMID 20458337

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC93240

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphoribosylaminoimidazole carboxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoribosylaminoimidazole carboxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphoribosylaminoimidazole carboxylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in 'de novo' AMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in 'de novo' IMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 'de novo' IMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 'de novo' IMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in 'de novo' XMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in G1/S transition of mitotic cell cycle IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in GMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in purine nucleobase biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in purine nucleobase biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase
Names
AIR carboxylase-SAICAR synthetase
multifunctional protein ADE2
multifunctional protein ADE2-like
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole succinocarboxamide synthetase
phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazolesuccinocarboxamide synthase
phosphoribosylaminoimidazolesuccinocarboxamide synthase
NP_543186.1
XP_006250914.1
XP_006250915.1
XP_006250916.1
XP_063128886.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001433942.1 → NP_001420871.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014

  2. NM_001433943.1 → NP_001420872.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014

  3. NM_080910.4 → NP_543186.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

    See identical proteins and their annotated locations for NP_543186.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/Swiss-Prot
    P51583
    UniProtKB/TrEMBL
    A6JCW6, A6JCW8
    Related
    ENSRNOP00000061495.2, ENSRNOT00000063942.3
    Conserved Domains (2) summary
    cd01416
    Location:7 → 258
    SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
    TIGR01162
    Location:268 → 421
    purE; phosphoribosylaminoimidazole carboxylase, PurE protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    31553355..31586843 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272816.1 → XP_063128886.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X1

    UniProtKB/TrEMBL
    A0A8I6A960
    Related
    ENSRNOP00000089961.1, ENSRNOT00000096789.2

  2. XM_006250853.5 → XP_006250915.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X2

    UniProtKB/Swiss-Prot
    P51583
    UniProtKB/TrEMBL
    A6JCW6, A6JCW8
    Conserved Domains (2) summary
    cd01416
    Location:7 → 258
    SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
    TIGR01162
    Location:268 → 421
    purE; phosphoribosylaminoimidazole carboxylase, PurE protein

  3. XM_006250854.3 → XP_006250916.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X2

    See identical proteins and their annotated locations for XP_006250916.1

    UniProtKB/Swiss-Prot
    P51583
    UniProtKB/TrEMBL
    A6JCW6, A6JCW8
    Conserved Domains (2) summary
    cd01416
    Location:7 → 258
    SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
    TIGR01162
    Location:268 → 421
    purE; phosphoribosylaminoimidazole carboxylase, PurE protein

  4. XM_006250852.4 → XP_006250914.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X2

    UniProtKB/Swiss-Prot
    P51583
    UniProtKB/TrEMBL
    A6JCW6, A6JCW8
    Conserved Domains (2) summary
    cd01416
    Location:7 → 258
    SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
    TIGR01162
    Location:268 → 421
    purE; phosphoribosylaminoimidazole carboxylase, PurE protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51583.3 GenPept UniProtKB/Swiss-Prot:P51583

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