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Fbl fibrillarin [ Mus musculus (house mouse) ]

Gene ID: 14113, updated on 2-Nov-2024

Summary

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Official Symbol
Fblprovided by MGI
Official Full Name
fibrillarinprovided by MGI
Primary source
MGI:MGI:95486
See related
Ensembl:ENSMUSG00000046865 AllianceGenome:MGI:95486
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FIB; FLRN; RNU3IP1
Summary
Enables RNA binding activity. Acts upstream of or within sno(s)RNA metabolic process. Located in Cajal body and granular component. Is expressed in several structures, including central nervous system; early embryo; oocyte; retina; and submandibular gland primordium. Orthologous to human FBL (fibrillarin). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 132.0), liver E14 (RPKM 128.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Fbl in Genome Data Viewer
Location:
7 A3; 7 16.67 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (27868293..27878701)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28168893..28179269)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene tectorin alpha pseudogene Neighboring gene predicted gene, 38976 Neighboring gene Fc fragment of IgG binding protein like 1 Neighboring gene STARR-seq mESC enhancer starr_18401 Neighboring gene STARR-seq mESC enhancer starr_18402 Neighboring gene STARR-positive B cell enhancer ABC_E6526 Neighboring gene predicted gene, 31024 Neighboring gene STARR-positive B cell enhancer ABC_E9687 Neighboring gene dual-specificity tyrosine phosphorylation regulated kinase 1b Neighboring gene STARR-seq mESC enhancer starr_18404 Neighboring gene STARR-seq mESC enhancer starr_18406 Neighboring gene STARR-seq mESC enhancer starr_18407 Neighboring gene STARR-seq mESC enhancer starr_18408 Neighboring gene ring finger and WD repeat domain 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. [Analysis of the Localization of Fibrillarin and Sites of Pre-rRNA Synthesis in the Nucleolus-Like Bodies of Mouse GV Oocytes after Mild Treatment with Proteinase K]. Shishova KV, et al. Ontogenez, 2015 May-Jun. PMID 26204768
  2. Immunocytochemical localisation of the nucleolar protein fibrillarin and RNA polymerase I during mouse early embryogenesis. Cuadros-Fernández JM, et al. Zygote, 1996 Feb. PMID 8735370
  3. Molecular cloning and sequence analysis of U3 snoRNA-associated mouse fibrillarin. Turley SJ, et al. Biochim Biophys Acta, 1993 Oct 19. PMID 8218401
  4. Autoantibody to U3 nucleolar ribonucleoprotein (fibrillarin) in patients with systemic sclerosis. Okano Y, et al. Arthritis Rheum, 1992 Jan. PMID 1731817
  5. Fibrillarin is essential for early development and required for accumulation of an intron-encoded small nucleolar RNA in the mouse. Newton K, et al. Mol Cell Biol, 2003 Dec. PMID 14612397, Free PMC Article

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Selective translation of epigenetic modifiers affects the temporal pattern and differentiation of neural stem cells.
    Title: Selective translation of epigenetic modifiers affects the temporal pattern and differentiation of neural stem cells.
  2. Analysis of the Localization of Fibrillarin and Sites of Pre-rRNA Synthesis in the Nucleolus-Like Bodies of Mouse GV Oocytes after Mild Treatment with Proteinase K
    Title: [Analysis of the Localization of Fibrillarin and Sites of Pre-rRNA Synthesis in the Nucleolus-Like Bodies of Mouse GV Oocytes after Mild Treatment with Proteinase K].
  3. SUV39h1 associated with HP1 beta in fibrillarin-positive nucleolar regions.
    Title: SUV39h-independent association of HP1 beta with fibrillarin-positive nucleolar regions.
  4. massive apoptosis was observed in early Fibrillarin(-/-) embryos, showing that fibrillarin is essential for development
    Title: Fibrillarin is essential for early development and required for accumulation of an intron-encoded small nucleolar RNA in the mouse.
  5. Results suggest that proteasome-dependent processing of fibrillarin occurs upon mercury induction.
    Title: Subcellular recruitment of fibrillarin to nucleoplasmic proteasomes: implications for processing of a nucleolar autoantigen.
  6. This splicing factor was more abundant in hepatocyte nuclei of mice fed genetically-modified soybeans than in control mice.
    Title: Ultrastructural morphometrical and immunocytochemical analyses of hepatocyte nuclei from mice fed on genetically modified soybean.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase binding IEA
Inferred from Electronic Annotation
more info
  
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables TFIID-class transcription factor complex binding IEA
Inferred from Electronic Annotation
more info
  
enables TFIID-class transcription factor complex binding ISO
Inferred from Sequence Orthology
more info
  
enables U6 snRNA 2'-O-ribose methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AQ104 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H2AQ104 methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H2AQ104 methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables rRNA methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in box C/D sno(s)RNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in rRNA methylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ribosomal small subunit biogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosomal small subunit biogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within sno(s)RNA metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in snoRNA localization IEA
Inferred from Electronic Annotation
more info
  
involved_in snoRNA localization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Cajal body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Cajal body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Cajal body ISO
Inferred from Sequence Orthology
more info
  
part_of box C/D methylation guide snoRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in dense fibrillar component ISO
Inferred from Sequence Orthology
more info
  
located_in fibrillar center IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in granular component IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of small-subunit processome ISO
Inferred from Sequence Orthology
more info
  
part_of small-subunit processome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
rRNA 2'-O-methyltransferase fibrillarin
Names
U6 snRNA 2'-O-methyltransferase fibrillarin
histone-glutamine methyltransferase
nucleolar protein 1
NP_001399349.1
NP_032017.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001412420.1 → NP_001399349.1  rRNA 2'-O-methyltransferase fibrillarin isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC141883

  2. NM_007991.4 → NP_032017.2  rRNA 2'-O-methyltransferase fibrillarin isoform 1

    See identical proteins and their annotated locations for NP_032017.2

    Status: VALIDATED

    Source sequence(s)
    AC141883
    Consensus CDS
    CCDS21036.1
    UniProtKB/Swiss-Prot
    P35550, Q99L58
    UniProtKB/TrEMBL
    Q3UJS2
    Related
    ENSMUSP00000037613.7, ENSMUST00000042405.8
    Conserved Domains (1) summary
    PTZ00146
    Location:88 → 326
    PTZ00146; fibrillarin; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    27868293..27878701
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35550.2 GenPept UniProtKB/Swiss-Prot:P35550

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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