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Fgfbp1 fibroblast growth factor binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 14181, updated on 2-Nov-2024

Summary

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Official Symbol
Fgfbp1provided by MGI
Official Full Name
fibroblast growth factor binding protein 1provided by MGI
Primary source
MGI:MGI:1096350
See related
Ensembl:ENSMUSG00000048373 AllianceGenome:MGI:1096350
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FGF-BP; FGF-BP1; FGFBP-1
Summary
Enables fibroblast growth factor binding activity. Acts upstream of or within positive regulation of fibroblast growth factor receptor signaling pathway and positive regulation of myoblast proliferation. Located in cell surface and extracellular region. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and skin. Orthologous to human FGFBP1 (fibroblast growth factor binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in large intestine adult (RPKM 24.0), stomach adult (RPKM 14.7) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Fgfbp1 in Genome Data Viewer
Location:
5 B3; 5 23.95 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (44136200..44139173, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (43978858..43981828, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene apurinic/apyrimidinic endonuclease 2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6327 Neighboring gene STARR-positive B cell enhancer ABC_E6328 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:44339668-44339851 Neighboring gene ribosomal protein L15 pseudogene Neighboring gene STARR-seq mESC enhancer starr_12982 Neighboring gene STARR-seq mESC enhancer starr_12983 Neighboring gene prominin 1 Neighboring gene predicted gene 16401 Neighboring gene predicted gene, 35900 Neighboring gene STARR-seq mESC enhancer starr_12986

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Spontaneous adenocarcinoma of the colon in a DDD mouse. Madarame H, et al. Lab Anim Sci, 1993 Feb. PMID 8384674
  2. Acute Kidney Injury Sensitizes the Brain Vasculature to Ang II (Angiotensin II) Constriction via FGFBP1 (Fibroblast Growth Factor Binding Protein 1). Zhao L, et al. Hypertension, 2020 Dec. PMID 33040621, Free PMC Article
  3. The Role of Fibroblast Growth Factor-Binding Protein 1 in Skin Carcinogenesis and Inflammation. Schmidt MO, et al. J Invest Dermatol, 2018 Jan. PMID 28864076, Free PMC Article
  4. Targeting FAPα-expressing hepatic stellate cells overcomes resistance to antiangiogenics in colorectal cancer liver metastasis models. Qi M, et al. J Clin Invest, 2022 Oct 3. PMID 35951441, Free PMC Article
  5. Expression of a binding protein for FGF is associated with epithelial development and skin carcinogenesis. Kurtz A, et al. Oncogene, 1997 Jun 5. PMID 9178765

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Targeting FAPalpha-expressing hepatic stellate cells overcomes resistance to antiangiogenics in colorectal cancer liver metastasis models.
    Title: Targeting FAPα-expressing hepatic stellate cells overcomes resistance to antiangiogenics in colorectal cancer liver metastasis models.
  2. Poly-L-arginine promotes asthma angiogenesis through induction of FGFBP1 in airway epithelial cells via activation of the mTORC1-STAT3 pathway.
    Title: Poly-L-arginine promotes asthma angiogenesis through induction of FGFBP1 in airway epithelial cells via activation of the mTORC1-STAT3 pathway.
  3. Acute Kidney Injury Sensitizes the Brain Vasculature to Ang II (Angiotensin II) Constriction via FGFBP1 (Fibroblast Growth Factor Binding Protein 1).
    Title: Acute Kidney Injury Sensitizes the Brain Vasculature to Ang II (Angiotensin II) Constriction via FGFBP1 (Fibroblast Growth Factor Binding Protein 1).
  4. Fgfbp1 promotes blood-brain barrier development by regulating collagen IV deposition and maintaining Wnt/beta-catenin signaling.
    Title: Fgfbp1 promotes blood-brain barrier development by regulating collagen IV deposition and maintaining Wnt/β-catenin signaling.
  5. Study using Fgfbp1-knockout mice concludes that tissue-resident and circulating Fgfbp1-expressing cells modulate skin carcinogenesis and inflammation.
    Title: The Role of Fibroblast Growth Factor-Binding Protein 1 in Skin Carcinogenesis and Inflammation.
  6. FGFBP1 expression decreases in skeletal muscles during aging and before neuromuscular junctions degeneration in SOD1(G93A) mice
    Title: Muscle Fibers Secrete FGFBP1 to Slow Degeneration of Neuromuscular Synapses during Aging and Progression of ALS.
  7. From the locally confined, time-dependent, and apparently tightly regulated FGF-BP expression, it is proposed that FGF-BP may play an important role in embryonic development.
    Title: Immunolocalization of an FGF-binding protein reveals a widespread expression pattern during different stages of mouse embryo development.
  8. The upregulation of FGF-BP by regenerating renal tubular epithelial cells may provide a mechanism by which the regenerative and angiogenic activity of FGF-2 in renal capillaries can be modulated in children with HIV-HUS and other renal disease.
    Title: Role of fibroblast growth factor-binding protein in the pathogenesis of HIV-associated hemolytic uremic syndrome.
  9. the FGF interaction domain is contained in the C terminus of FGF-BP1
    Title: Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables fibroblast growth factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell-cell signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell signaling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of myoblast proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration involved in sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of myoblast proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
fibroblast growth factor-binding protein 1
Names
FGF-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271616.1 → NP_001258545.1  fibroblast growth factor-binding protein 1 precursor

    See identical proteins and their annotated locations for NP_001258545.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC164004, BC065774, CB524251, DV059653
    Consensus CDS
    CCDS19268.1
    UniProtKB/Swiss-Prot
    O70514, Q62399
    Related
    ENSMUSP00000142520.2, ENSMUST00000199894.2
    Conserved Domains (1) summary
    pfam06473
    Location:15 → 247
    FGF-BP1; FGF binding protein 1 (FGF-BP1)

  2. NM_001421576.1 → NP_001408505.1  fibroblast growth factor-binding protein 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC164004
    UniProtKB/Swiss-Prot
    O70514, Q62399

  3. NM_001421577.1 → NP_001408506.1  fibroblast growth factor-binding protein 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC164004
    UniProtKB/Swiss-Prot
    O70514, Q62399
    Related
    ENSMUSP00000143011.2, ENSMUST00000199481.2

  4. NM_008009.4 → NP_032035.2  fibroblast growth factor-binding protein 1 precursor

    See identical proteins and their annotated locations for NP_032035.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC164004, BC065774, CB524251
    Consensus CDS
    CCDS19268.1
    UniProtKB/Swiss-Prot
    O70514, Q62399
    Related
    ENSMUSP00000056900.8, ENSMUST00000061299.9
    Conserved Domains (1) summary
    pfam06473
    Location:15 → 247
    FGF-BP1; FGF binding protein 1 (FGF-BP1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    44136200..44139173 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503712.5 → XP_006503775.1  fibroblast growth factor-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006503775.1

    UniProtKB/Swiss-Prot
    O70514, Q62399
    Conserved Domains (1) summary
    pfam06473
    Location:15 → 247
    FGF-BP1; FGF binding protein 1 (FGF-BP1)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70514.1 GenPept UniProtKB/Swiss-Prot:O70514

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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