Lpin1 lipin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lpin1provided by MGI
Official Full Name: lipin 1provided by MGI
Primary source: MGI:MGI:1891340
See related: Ensembl:ENSMUSG00000020593 AllianceGenome:MGI:1891340
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: fld; Lipin1
Summary: Enables several functions, including histone deacetylase binding activity; peroxisome proliferator activated receptor binding activity; and phosphatidate phosphatase activity. Involved in several processes, including mitochondrial fission; positive regulation of cold-induced thermogenesis; and triglyceride metabolic process. Acts upstream of or within several processes, including cellular response to insulin stimulus; negative regulation of transcription by RNA polymerase II; and ruffle organization. Located in endoplasmic reticulum; mitochondrial outer membrane; and nuclear membrane. Part of transcription regulator complex. Is active in endoplasmic reticulum membrane. Is expressed in liver; nervous system; olfactory epithelium; and tooth. Used to study lipodystrophy. Orthologous to human LPIN1 (lipin 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in testis adult (RPKM 79.1), subcutaneous fat pad adult (RPKM 36.4) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 A1.1; 12 7.9 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (16585670..16697020, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (16535669..16653903, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exploring lipin1 as a promising therapeutic target for the treatment of Duchenne muscular dystrophy.
Title: Exploring lipin1 as a promising therapeutic target for the treatment of Duchenne muscular dystrophy.
Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and nucleocytoplasmic localization of Lipin1.
Title: Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and nucleocytoplasmic localization of Lipin1.
Lipin-1 deficiency deteriorates defect of fatty acid beta-oxidation and lipid-related kidney damage in diabetic kidney disease.
Title: Lipin-1 deficiency deteriorates defect of fatty acid β-oxidation and lipid-related kidney damage in diabetic kidney disease.
Lipin1 plays complementary roles in myofibre stability and regeneration in dystrophic muscles.
Title: Lipin1 plays complementary roles in myofibre stability and regeneration in dystrophic muscles.
LPIN1 is a new target gene for essential hypertension.
Title: LPIN1 is a new target gene for essential hypertension.
Myocardial Lipin 1 knockout in mice approximates cardiac effects of human LPIN1 mutations.
Title: Myocardial Lipin 1 knockout in mice approximates cardiac effects of human LPIN1 mutations.
Macrophage-Associated Lipin-1 Promotes beta-Oxidation in Response to Proresolving Stimuli.
Title: Macrophage-Associated Lipin-1 Promotes β-Oxidation in Response to Proresolving Stimuli.
Myeloid-associated lipin-1 transcriptional co-regulatory activity is atheroprotective.
Title: Myeloid-associated lipin-1 transcriptional co-regulatory activity is atheroprotective.
Loss of membrane integrity drives myofiber death in lipin1-deficient skeletal muscle.
Title: Loss of membrane integrity drives myofiber death in lipin1-deficient skeletal muscle.
The middle lipin domain adopts a membrane-binding dimeric protein fold.
Title: The middle lipin domain adopts a membrane-binding dimeric protein fold.

Submit: New GeneRIF Correction See all GeneRIFs (88)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (4)
Spontaneous (2) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

L12SP6 (e-PCR), detects polymorphism
- UniSTS:158737

A19T7 (e-PCR), detects polymorphism
- UniSTS:158676

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	IDA Inferred from Direct Assay more info	PubMed
enables histone deacetylase binding	IDA Inferred from Direct Assay more info	PubMed
enables peroxisome proliferator activated receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphatidate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidate phosphatase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables phosphatidate phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphatidate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidate phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to insulin stimulus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to insulin stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in fat cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in fatty acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial fission	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of myelination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phosphatidic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidic acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylethanolamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylethanolamine metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA replication	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ruffle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in triglyceride biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in triglyceride biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in triglyceride biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in triglyceride biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in triglyceride mobilization	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: phosphatidate phosphatase LPIN1

Names: fatty liver dystrophy protein

NP_001123884.1

EC 3.1.3.4

NP_001342527.1

EC 3.1.3.4

NP_056578.2

EC 3.1.3.4

NP_766538.2

EC 3.1.3.4

XP_006515038.1

EC 3.1.3.4

XP_006515039.1

EC 3.1.3.4

XP_006515040.1

EC 3.1.3.4

XP_006515041.1

EC 3.1.3.4

XP_006515045.1

EC 3.1.3.4

XP_006515046.1

EC 3.1.3.4

XP_006515047.1

EC 3.1.3.4

XP_006515049.1

EC 3.1.3.4

XP_006515050.1

EC 3.1.3.4

XP_011242117.1

EC 3.1.3.4

XP_030102417.1

EC 3.1.3.4

XP_030102419.1

EC 3.1.3.4

XP_030102420.1

EC 3.1.3.4

XP_036013081.1

EC 3.1.3.4

XP_036013082.1

EC 3.1.3.4

XP_036013083.1

EC 3.1.3.4

XP_036013084.1

EC 3.1.3.4

XP_036013085.1

EC 3.1.3.4

XP_036013086.1

EC 3.1.3.4

XP_036013087.1

EC 3.1.3.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130412.1 → NP_001123884.1 phosphatidate phosphatase LPIN1 isoform a

See identical proteins and their annotated locations for NP_001123884.1

Status: VALIDATED

Description

Transcript Variant: This variant differs in the 5' UTR, compared to variant 1. This variant encodes isoform a. Isoform a is also known as isoform alpha. Variants 1 and 3 encode the same isoform.

Source sequence(s)

AK009789, AK014526, AK030921, BY127780, BY209929, CK621866, CX205142

Consensus CDS

CCDS25823.1

UniProtKB/TrEMBL

A0A1Y7VLN4, Q3U3C3, Q8CD95

Related

ENSMUSP00000152276.2, ENSMUST00000222989.2

Conserved Domains (4) summary

pfam15017
Location:856 → 885

AF1Q; Drug resistance and apoptosis regulator

pfam04571
Location:1 → 106

Lipin_N; lipin, N-terminal conserved region

pfam08235
Location:627 → 852

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam16876
Location:465 → 555

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
NM_001355598.1 → NP_001342527.1 phosphatidate phosphatase LPIN1 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant differs in the 5' UTR and includes an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in a longer protein (isoform b), compared to isoform a. Isoform b is also known as isoform beta. Variants 2 and 4 encode the same isoform.

Source sequence(s)

AC159631, AK019539

Consensus CDS

CCDS25822.1

UniProtKB/Swiss-Prot

Q91ZP3, Q9CQI2, Q9JLG6

UniProtKB/TrEMBL

A0A0R4J0V3, E9QKQ5

Related

ENSMUSP00000106696.4, ENSMUST00000111067.10

Conserved Domains (3) summary

pfam04571
Location:1 → 107

Lipin_N; lipin, N-terminal conserved region

pfam08235
Location:660 → 885

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam16876
Location:498 → 589

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
NM_015763.4 → NP_056578.2 phosphatidate phosphatase LPIN1 isoform b

See identical proteins and their annotated locations for NP_056578.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) includes an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in a longer protein (isoform b), compared to isoform a. Isoform b is also known as isoform beta. Variants 2 and 4 encode the same isoform.

Source sequence(s)

AK009789, AK014526, BY127780, CK621866, CX205142

Consensus CDS

CCDS25822.1

UniProtKB/Swiss-Prot

Q91ZP3, Q9CQI2, Q9JLG6

UniProtKB/TrEMBL

A0A0R4J0V3, E9QKQ5

Related

ENSMUSP00000070583.6, ENSMUST00000067124.6

Conserved Domains (3) summary

pfam04571
Location:1 → 107

Lipin_N; lipin, N-terminal conserved region

pfam08235
Location:660 → 885

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam16876
Location:498 → 589

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
NM_172950.3 → NP_766538.2 phosphatidate phosphatase LPIN1 isoform a

See identical proteins and their annotated locations for NP_766538.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shortest transcript and encodes the shorter isoform (a). Isoform a is also known as isoform alpha. Variants 1 and 3 encode the same isoform.

Source sequence(s)

AK009789, AK014526, AK030921, BY127780, CK621866, CX205142

Consensus CDS

CCDS25823.1

UniProtKB/TrEMBL

A0A1Y7VLN4, Q3U3C3, Q8CD95

Related

ENSMUSP00000152466.2, ENSMUST00000221230.2

Conserved Domains (4) summary

pfam15017
Location:856 → 885

AF1Q; Drug resistance and apoptosis regulator

pfam04571
Location:1 → 106

Lipin_N; lipin, N-terminal conserved region

pfam08235
Location:627 → 852

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam16876
Location:465 → 555

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

16585670..16697020 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006514975.4 → XP_006515038.1 phosphatidate phosphatase LPIN1 isoform X1

UniProtKB/TrEMBL

A0A5F8MPG1

Conserved Domains (4) summary

pfam04571
Location:61 → 166

Lipin_N; lipin, N-terminal conserved region

pfam08235
Location:746 → 971

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam15402
Location:237 → 429

Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7

pfam16876
Location:558 → 631

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
XM_036157191.1 → XP_036013084.1 phosphatidate phosphatase LPIN1 isoform X11

UniProtKB/Swiss-Prot

Q91ZP3, Q9CQI2, Q9JLG6

UniProtKB/TrEMBL

A0A0R4J0V3, E9QKQ5

Conserved Domains (3) summary

pfam04571
Location:1 → 107

Lipin_N; lipin, N-terminal conserved region

pfam08235
Location:660 → 885

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam16876
Location:498 → 589

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
XM_006514977.4 → XP_006515040.1 phosphatidate phosphatase LPIN1 isoform X4

UniProtKB/TrEMBL

A0A5F8MPG1

Related

ENSMUSP00000158955.2, ENSMUST00000238839.2

Conserved Domains (4) summary

pfam04571
Location:61 → 166

Lipin_N; lipin, N-terminal conserved region

pfam08235
Location:720 → 945

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam15402
Location:237 → 429

Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7

pfam16876
Location:558 → 648

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
XM_030246557.2 → XP_030102417.1 phosphatidate phosphatase LPIN1 isoform X5

UniProtKB/TrEMBL

A0A5F8MPG1

Conserved Domains (4) summary

pfam04571
Location:61 → 166

Lipin_N; lipin, N-terminal conserved region

pfam08235
Location:719 → 944

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam15402
Location:237 → 428

Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7

pfam16876
Location:557 → 647

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
XM_006514982.5 → XP_006515045.1 phosphatidate phosphatase LPIN1 isoform X6

UniProtKB/TrEMBL

A0A5F8MPG1

Conserved Domains (3) summary

pfam04571
Location:61 → 166

Lipin_N; lipin, N-terminal conserved region

pfam08235
Location:687 → 912

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam16876
Location:525 → 615

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
XM_036157189.1 → XP_036013082.1 phosphatidate phosphatase LPIN1 isoform X10

UniProtKB/Swiss-Prot

Q91ZP3, Q9CQI2, Q9JLG6

Conserved Domains (3) summary

pfam04571
Location:21 → 127

Lipin_N; lipin, N-terminal conserved region

pfam08235
Location:680 → 905

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam16876
Location:518 → 609

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
XM_036157188.1 → XP_036013081.1 phosphatidate phosphatase LPIN1 isoform X9

UniProtKB/Swiss-Prot

Q91ZP3, Q9CQI2, Q9JLG6

Conserved Domains (3) summary

pfam04571
Location:25 → 131

Lipin_N; lipin, N-terminal conserved region

pfam08235
Location:684 → 909

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam16876
Location:522 → 613

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
XM_036157190.1 → XP_036013083.1 phosphatidate phosphatase LPIN1 isoform X10

UniProtKB/Swiss-Prot

Q91ZP3, Q9CQI2, Q9JLG6

Conserved Domains (3) summary

pfam04571
Location:21 → 127

Lipin_N; lipin, N-terminal conserved region

pfam08235
Location:680 → 905

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam16876
Location:518 → 609

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
XM_030246559.2 → XP_030102419.1 phosphatidate phosphatase LPIN1 isoform X13

UniProtKB/TrEMBL

Q3U3C3, Q8CD95

Conserved Domains (3) summary

pfam04571
Location:1 → 106

Lipin_N; lipin, N-terminal conserved region

pfam08235
Location:653 → 878

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam16876
Location:465 → 538

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
XM_036157193.1 → XP_036013086.1 phosphatidate phosphatase LPIN1 isoform X12

UniProtKB/Swiss-Prot

Q91ZP3, Q9CQI2, Q9JLG6

Conserved Domains (3) summary

pfam04571
Location:1 → 107

Lipin_N; lipin, N-terminal conserved region

pfam08235
Location:659 → 884

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam16876
Location:497 → 588

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
XM_036157192.1 → XP_036013085.1 phosphatidate phosphatase LPIN1 isoform X11

UniProtKB/Swiss-Prot

Q91ZP3, Q9CQI2, Q9JLG6

UniProtKB/TrEMBL

A0A0R4J0V3, E9QKQ5

Related

ENSMUSP00000152285.2, ENSMUST00000221297.2

Conserved Domains (3) summary

pfam04571
Location:1 → 107

Lipin_N; lipin, N-terminal conserved region

pfam08235
Location:660 → 885

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam16876
Location:498 → 589

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
XM_006514978.5 → XP_006515041.1 phosphatidate phosphatase LPIN1 isoform X3

UniProtKB/TrEMBL

A0A5F8MPG1

Conserved Domains (3) summary

pfam04571
Location:61 → 166

Lipin_N; lipin, N-terminal conserved region

pfam08235
Location:713 → 938

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam16876
Location:525 → 598

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
XM_006514976.5 → XP_006515039.1 phosphatidate phosphatase LPIN1 isoform X2

UniProtKB/TrEMBL

A0A5F8MPG1

Conserved Domains (4) summary

pfam04571
Location:61 → 166

Lipin_N; lipin, N-terminal conserved region

pfam08235
Location:745 → 970

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam15402
Location:237 → 428

Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7

pfam16876
Location:557 → 630

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
XM_006514987.5 → XP_006515050.1 phosphatidate phosphatase LPIN1 isoform X8

UniProtKB/Swiss-Prot

Q91ZP3, Q9CQI2, Q9JLG6

Conserved Domains (4) summary

pfam04571
Location:1 → 106

Lipin_N; lipin, N-terminal conserved region

pfam08235
Location:685 → 910

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam15402
Location:177 → 368

Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7

pfam16876
Location:497 → 570

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
XM_006514983.5 → XP_006515046.1 phosphatidate phosphatase LPIN1 isoform X7

See identical proteins and their annotated locations for XP_006515046.1

UniProtKB/Swiss-Prot

Q91ZP3, Q9CQI2, Q9JLG6

UniProtKB/TrEMBL

A0A5F8MQ53

Related

ENSMUSP00000159076.2, ENSMUST00000239165.2

Conserved Domains (4) summary

pfam04571
Location:1 → 106

Lipin_N; lipin, N-terminal conserved region

pfam08235
Location:686 → 911

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam15402
Location:177 → 369

Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7

pfam16876
Location:498 → 571

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
XM_011243815.4 → XP_011242117.1 phosphatidate phosphatase LPIN1 isoform X14

UniProtKB/TrEMBL

Q8CFH3

Conserved Domains (2) summary

pfam08235
Location:505 → 730

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam16876
Location:317 → 434

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
XM_006514984.5 → XP_006515047.1 phosphatidate phosphatase LPIN1 isoform X7

See identical proteins and their annotated locations for XP_006515047.1

UniProtKB/Swiss-Prot

Q91ZP3, Q9CQI2, Q9JLG6

UniProtKB/TrEMBL

A0A5F8MQ53

Conserved Domains (4) summary

pfam04571
Location:1 → 106

Lipin_N; lipin, N-terminal conserved region

pfam08235
Location:686 → 911

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam15402
Location:177 → 369

Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7

pfam16876
Location:498 → 571

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
XM_036157194.1 → XP_036013087.1 phosphatidate phosphatase LPIN1 isoform X14

UniProtKB/TrEMBL

Q8CFH3

Conserved Domains (2) summary

pfam08235
Location:505 → 730

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam16876
Location:317 → 434

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
XM_030246560.2 → XP_030102420.1 phosphatidate phosphatase LPIN1 isoform X13

UniProtKB/TrEMBL

Q3U3C3, Q8CD95

Conserved Domains (3) summary

pfam04571
Location:1 → 106

Lipin_N; lipin, N-terminal conserved region

pfam08235
Location:653 → 878

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam16876
Location:465 → 538

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
XM_006514986.5 → XP_006515049.1 phosphatidate phosphatase LPIN1 isoform X7

See identical proteins and their annotated locations for XP_006515049.1

UniProtKB/Swiss-Prot

Q91ZP3, Q9CQI2, Q9JLG6

UniProtKB/TrEMBL

A0A5F8MQ53

Conserved Domains (4) summary

pfam04571
Location:1 → 106

Lipin_N; lipin, N-terminal conserved region

pfam08235
Location:686 → 911

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam15402
Location:177 → 369

Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7

pfam16876
Location:498 → 571

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain