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Fmod fibromodulin [ Mus musculus (house mouse) ]

Gene ID: 14264, updated on 2-Nov-2024

Summary

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Official Symbol
Fmodprovided by MGI
Official Full Name
fibromodulinprovided by MGI
Primary source
MGI:MGI:1328364
See related
Ensembl:ENSMUSG00000041559 AllianceGenome:MGI:1328364
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FM; SLRR2E
Summary
Predicted to be located in collagen-containing extracellular matrix and extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including central nervous system; heart and pericardium; jaw; limb; and skeleton. Orthologous to human FMOD (fibromodulin). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in limb E14.5 (RPKM 35.1), genital fat pad adult (RPKM 32.6) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Fmod in Genome Data Viewer
Location:
1 E4; 1 58.09 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (133964992..133976018)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (134037254..134048280)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene bone marrow associated noncoding RNA Neighboring gene malonyl CoA:ACP acyltransferase (mitochondrial) pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5804 Neighboring gene VISTA enhancer mm1445 Neighboring gene predicted gene, 19497 Neighboring gene STARR-positive B cell enhancer ABC_E992 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:135968249-135968432 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:135974032-135974219 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:135974224-135974473 Neighboring gene STARR-positive B cell enhancer ABC_E5805 Neighboring gene Btg2R3 erythroid cis-regulatory module Neighboring gene BTG anti-proliferation factor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Differential effects of fibromodulin deficiency on mouse mandibular bones and teeth: a micro-CT time course study. Goldberg M, et al. Cells Tissues Organs, 2011. PMID 21597266, Free PMC Article
  2. Fibromodulin-deficient mice reveal dual functions for fibromodulin in regulating dental tissue and alveolar bone formation. Goldberg M, et al. Cells Tissues Organs, 2009. PMID 18698127, Free PMC Article
  3. Fibromodulin-deficiency alters temporospatial expression patterns of transforming growth factor-β ligands and receptors during adult mouse skin wound healing. Zheng Z, et al. PLoS One, 2014. PMID 24603701, Free PMC Article
  4. Collagen-binding proteoglycan fibromodulin can determine stroma matrix structure and fluid balance in experimental carcinoma. Oldberg A, et al. Proc Natl Acad Sci U S A, 2007 Aug 28. PMID 17715296, Free PMC Article
  5. Increased C-telopeptide cross-linking of tendon type I collagen in fibromodulin-deficient mice. Kalamajski S, et al. J Biol Chem, 2014 Jul 4. PMID 24849606, Free PMC Article

See all (101) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FMOD Alleviates Depression-Like Behaviors by Targeting the PI3K/AKT/mTOR Signaling After Traumatic Brain Injury.
    Title: FMOD Alleviates Depression-Like Behaviors by Targeting the PI3K/AKT/mTOR Signaling After Traumatic Brain Injury.
  2. Dark pigmentation and related low FMOD expression increase IL-3 and facilitateplasmacytoid dendritic cell maturation.
    Title: Dark pigmentation and related low FMOD expression increase IL-3 and facilitateplasmacytoid dendritic cell maturation.
  3. Extracellular matrix components and elasticity regulate mouse vaginal epithelial differentiation induced by mesenchymal cellsdagger.
    Title: Extracellular matrix components and elasticity regulate mouse vaginal epithelial differentiation induced by mesenchymal cells†.
  4. Interaction of Fibromodulin and Myostatin to Regulate Skeletal Muscle Aging: An Opposite Regulation in Muscle Aging, Diabetes, and Intracellular Lipid Accumulation.
    Title: Interaction of Fibromodulin and Myostatin to Regulate Skeletal Muscle Aging: An Opposite Regulation in Muscle Aging, Diabetes, and Intracellular Lipid Accumulation.
  5. OPG-Fc treatment partially rescues low bone mass phenotype in mature Bgn/Fmod deficient mice but is deleterious to the young mouse skeleton.
    Title: OPG-Fc treatment partially rescues low bone mass phenotype in mature Bgn/Fmod deficient mice but is deleterious to the young mouse skeleton.
  6. Influence of microcurrent on the modulation of remodelling genes in a wound healing assay.
    Title: Influence of microcurrent on the modulation of remodelling genes in a wound healing assay.
  7. this study suggests that downregulation of miR-340-5p plays a role in promoting cell proliferation and suppressing cell apoptosis of chondrocytes in Osteoarthritis (OA) mice through inhibition of the ERK signaling pathway via the FMOD gene.
    Title: Downregulated microRNA-340-5p promotes proliferation and inhibits apoptosis of chondrocytes in osteoarthritis mice through inhibiting the extracellular signal-regulated kinase signaling pathway by negatively targeting the FMOD gene.
  8. our data indicates that Bgn and Fmod expressed by the bone forming cells, are novel coupling ECM components that control bone mass through sequestration of TNFalpha and/or RANKL, thereby adjusting their bioavailability in order to regulate osteoclastogenesis.
    Title: Small leucine rich proteoglycans, a novel link to osteoclastogenesis.
  9. The extracellular matrix proteoglycan fibromodulin is upregulated in clinical and experimental heart failure and affects cardiac remodeling.
    Title: The extracellular matrix proteoglycan fibromodulin is upregulated in clinical and experimental heart failure and affects cardiac remodeling.
  10. FMOD affected the expressions of the Cav1.1 and Cav3.1 genes. FMOD regulates calcium channel activity. The mRNA expressions of Cav1.1 and Cav3.1 increased during muscle regeneration.
    Title: Fibromodulin modulates myoblast differentiation by controlling calcium channel.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
fibromodulin
Names
KSPG fibromodulin
collagen-binding 59 kDa protein
keratan sulfate proteoglycan fibromodulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021355.4 → NP_067330.1  fibromodulin precursor

    See identical proteins and their annotated locations for NP_067330.1

    Status: VALIDATED

    Source sequence(s)
    AC154872, AK032302
    Consensus CDS
    CCDS15301.1
    UniProtKB/Swiss-Prot
    P50608
    UniProtKB/TrEMBL
    Q543D2, Q8BNU3
    Related
    ENSMUSP00000035489.8, ENSMUST00000048183.8
    Conserved Domains (4) summary
    smart00013
    Location:75 → 109
    LRRNT; Leucine rich repeat N-terminal domain
    cd00116
    Location:136 → 359
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:107 → 130
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:176 → 235
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    133964992..133976018
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50608.1 GenPept UniProtKB/Swiss-Prot:P50608

Gene LinkOut

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