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DUSP19 dual specificity phosphatase 19 [ Homo sapiens (human) ]

Gene ID: 142679, updated on 2-Nov-2024

Summary

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Official Symbol
DUSP19provided by HGNC
Official Full Name
dual specificity phosphatase 19provided by HGNC
Primary source
HGNC:HGNC:18894
See related
Ensembl:ENSG00000162999 MIM:611437; AllianceGenome:HGNC:18894
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SKRP1; DUSP17; LMWDSP3; TS-DSP1
Summary
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
Expression
Low expression observed in reference dataset See more
Orthologs
mouse all
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Genomic context

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See DUSP19 in Genome Data Viewer
Location:
2q32.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (183078747..183100008)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (183567739..183589000)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (183943475..183964736)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA77 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:183934151-183934652 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:183935853-183936421 Neighboring gene keratin 8 pseudogene 10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16838 Neighboring gene uncharacterized LOC124907917 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:183989221-183989989 Neighboring gene nucleoporin 35 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:184037030-184037616 Neighboring gene uncharacterized LOC124906103

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. DUSP19 mediates spinal cord injury-induced apoptosis and inflammation in mouse primary microglia cells via the NF-kB signaling pathway. Xie XK, et al. Neurol Res, 2020 Jan. PMID 31813339
  2. Crystal structure of a novel mitogen-activated protein kinase phosphatase, SKRP1. Wei CH, et al. Proteins, 2011 Nov. PMID 21989941
  3. Molecular cloning and characterization of a novel human protein phosphatase, LMW-DSP3. Cheng H, et al. Int J Biochem Cell Biol, 2003 Feb. PMID 12479873
  4. Circ_HIPK3 alleviates CoCl(2)-induced apoptotic injury in neuronal cells by depending on the regulation of the miR-222-3p/DUSP19 axis. Liu Y, et al. Biochem Biophys Res Commun, 2021 May 14. PMID 33770577
  5. PTEN regulates invasiveness in pancreatic neuroendocrine tumors through DUSP19-mediated VEGFR3 dephosphorylation. Chang TM, et al. J Biomed Sci, 2022 Nov 6. PMID 36336681, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PTEN regulates invasiveness in pancreatic neuroendocrine tumors through DUSP19-mediated VEGFR3 dephosphorylation.
    Title: PTEN regulates invasiveness in pancreatic neuroendocrine tumors through DUSP19-mediated VEGFR3 dephosphorylation.
  2. Circ_HIPK3 alleviates CoCl2-induced apoptotic injury in neuronal cells by depending on the regulation of the miR-222-3p/DUSP19 axis.
    Title: Circ_HIPK3 alleviates CoCl(2)-induced apoptotic injury in neuronal cells by depending on the regulation of the miR-222-3p/DUSP19 axis.
  3. DUSP19 mediates spinal cord injury-induced apoptosis and inflammation in mouse primary microglia cells via the NF-kB signaling pathway.
    Title: DUSP19 mediates spinal cord injury-induced apoptosis and inflammation in mouse primary microglia cells via the NF-kB signaling pathway.
  4. the activity of JNK stimulated by leptin was suppressed by DUSP19 overexpression.
    Title: DUSP19, a downstream effector of leptin, inhibits chondrocyte apoptosis via dephosphorylating JNK during osteoarthritis pathogenesis.
  5. crystal structure of SKRP1 (C150S) has been determined and refined at 1.26 A resolution (Table I). The structure reveals 142 residues (residues 65-206) of SKRP1 and three ions (two sulfates and one phosphate) at the catalytic site
    Title: Crystal structure of a novel mitogen-activated protein kinase phosphatase, SKRP1.
  6. LMW-DSP3 was expressed in the heart, lung, liver, and pancreas, and the expression level in the pancreas was highest. The LMW-DSP3 gene was located in human chromosome 2q32, and consisted of five exons spanning 21kb of human genomic DNA[LMW-DSP3]
    Title: Molecular cloning and characterization of a novel human protein phosphatase, LMW-DSP3.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC138210

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables JUN kinase phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP-kinase scaffold activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables mitogen-activated protein kinase kinase kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein kinase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine/serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of JUN kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of JUN kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dual specificity protein phosphatase 19
Names
SAPK pathway-regulating phosphatase 1
dual specificity phosphatase TS-DSP1
low molecular weight dual specificity phosphatase 3
protein phosphatase SKRP1
stress-activated protein kinase pathway-regulating phosphatase 1
NP_001135786.1
NP_001308448.1
NP_543152.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142314.2 → NP_001135786.1  dual specificity protein phosphatase 19 isoform 2

    See identical proteins and their annotated locations for NP_001135786.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the mid coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AB063187, AC064871, BC035000
    Consensus CDS
    CCDS46469.1
    UniProtKB/Swiss-Prot
    Q8WTR2
    Related
    ENSP00000343905.6, ENST00000342619.10
    Conserved Domains (1) summary
    cl28904
    Location:65 → 150
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  2. NM_001321519.2 → NP_001308448.1  dual specificity protein phosphatase 19 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AB063186, AC064871, BX647818
    UniProtKB/Swiss-Prot
    Q8WTR2
    Conserved Domains (1) summary
    cl28904
    Location:65 → 96
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  3. NM_080876.4 → NP_543152.1  dual specificity protein phosphatase 19 isoform 1

    See identical proteins and their annotated locations for NP_543152.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB063186, AC064871, BC035000
    Consensus CDS
    CCDS2289.1
    UniProtKB/Swiss-Prot
    B2RA79, Q547H4, Q8WTR2, Q8WYN4
    Related
    ENSP00000346160.4, ENST00000354221.5
    Conserved Domains (1) summary
    cd14523
    Location:65 → 201
    DSP_DUSP19; dual specificity phosphatase domain of dual specificity protein phosphatase 19

RNA

  1. NR_135688.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AB063186, AC064871, BC143337

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    183078747..183100008
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    183567739..183589000
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WTR2.1 GenPept UniProtKB/Swiss-Prot:Q8WTR2

Gene LinkOut

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Chemical Information
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