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Asb14 ankyrin repeat and SOCS box-containing 14 [ Mus musculus (house mouse) ]

Gene ID: 142687, updated on 28-Oct-2024

Summary

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Official Symbol
Asb14provided by MGI
Official Full Name
ankyrin repeat and SOCS box-containing 14provided by MGI
Primary source
MGI:MGI:2655107
See related
Ensembl:ENSMUSG00000021898 AllianceGenome:MGI:2655107
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Asb-14
Summary
Predicted to enable small GTPase binding activity. Predicted to be involved in Golgi to lysosome transport and retrograde transport, endosome to Golgi. Predicted to be active in endosome membrane. Orthologous to human ASB14 (ankyrin repeat and SOCS box containing 14). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in heart adult (RPKM 27.4) and mammary gland adult (RPKM 3.1) See more
Orthologs
human all
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Genomic context

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See Asb14 in Genome Data Viewer
Location:
14 A3; 14 16.09 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (26616547..26638393)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (26894590..26915257)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:27489365-27489548 Neighboring gene phosphodiesterase 12 Neighboring gene microRNA 7672 Neighboring gene dynein, axonemal, heavy chain 12 Neighboring gene predicted gene, 34415 Neighboring gene STARR-seq mESC enhancer starr_36242 Neighboring gene STARR-seq mESC enhancer starr_36244 Neighboring gene predicted gene, 41115 Neighboring gene adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 Neighboring gene predicted gene, 41114

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. E3 Ubiquitin Ligase ASB14 Inhibits Cardiomyocyte Proliferation by Regulating MAPRE2 Ubiquitination. Yang Y, et al. Cell Biochem Biophys, 2024 Jun. PMID 38319584
  2. The SOCS box: a tale of destruction and degradation. Kile BT, et al. Trends Biochem Sci, 2002 May. PMID 12076535
  3. Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. Quina LA, et al. J Neurosci, 2009 Nov 11. PMID 19906978, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. E3 Ubiquitin Ligase ASB14 Inhibits Cardiomyocyte Proliferation by Regulating MAPRE2 Ubiquitination.
    Title: E3 Ubiquitin Ligase ASB14 Inhibits Cardiomyocyte Proliferation by Regulating MAPRE2 Ubiquitination.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Golgi to lysosome transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ankyrin repeat and SOCS box protein 14
Names
ankyrin repeat and SOCS box-containing protein 14
ankyrin repeat domain-containing SOCS box protein 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170748.2 → NP_001164219.2  ankyrin repeat and SOCS box protein 14 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK052884, BC145002
    Consensus CDS
    CCDS49431.2
    UniProtKB/Swiss-Prot
    B7ZN45, Q8C6Y6, Q8VHS7
    UniProtKB/TrEMBL
    A0A5F8MPW7
    Related
    ENSMUSP00000159151.2, ENSMUST00000238987.2
    Conserved Domains (4) summary
    PHA02875
    Location:116 → 343
    PHA02875; ankyrin repeat protein; Provisional
    sd00045
    Location:182 → 213
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:319 → 413
    Ank_2; Ankyrin repeats (3 copies)
    cl02533
    Location:529 → 585
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

  2. NM_080856.5 → NP_543132.4  ankyrin repeat and SOCS box protein 14 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 3' splice pattern, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK052884
    Consensus CDS
    CCDS36842.3
    UniProtKB/Swiss-Prot
    B7ZN45, Q8C6Y6, Q8VHS7
    UniProtKB/TrEMBL
    A0A5F8MPK4
    Related
    ENSMUSP00000159012.2, ENSMUST00000239004.2
    Conserved Domains (3) summary
    PHA02875
    Location:116 → 343
    PHA02875; ankyrin repeat protein; Provisional
    sd00045
    Location:182 → 213
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:319 → 413
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    26616547..26638393
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518555.5 → XP_006518618.1  ankyrin repeat and SOCS box protein 14 isoform X1

    UniProtKB/Swiss-Prot
    B7ZN45, Q8C6Y6, Q8VHS7
    Conserved Domains (4) summary
    PHA02875
    Location:145 → 372
    PHA02875; ankyrin repeat protein; Provisional
    sd00045
    Location:211 → 242
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:348 → 442
    Ank_2; Ankyrin repeats (3 copies)
    cl02533
    Location:558 → 614
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

  2. XM_011244955.3 → XP_011243257.1  ankyrin repeat and SOCS box protein 14 isoform X2

    See identical proteins and their annotated locations for XP_011243257.1

    UniProtKB/Swiss-Prot
    B7ZN45, Q8C6Y6, Q8VHS7
    Conserved Domains (4) summary
    PHA02875
    Location:15 → 242
    PHA02875; ankyrin repeat protein; Provisional
    sd00045
    Location:81 → 112
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:218 → 312
    Ank_2; Ankyrin repeats (3 copies)
    cl02533
    Location:428 → 484
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

  3. XM_036158465.1 → XP_036014358.1  ankyrin repeat and SOCS box protein 14 isoform X3

    Conserved Domains (3) summary
    sd00045
    Location:18 → 49
    ANK; ANK repeat [structural motif]
    cl02533
    Location:365 → 421
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    cl39094
    Location:5 → 253
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C6Y6.2 GenPept UniProtKB/Swiss-Prot:Q8C6Y6

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