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LIPJ lipase family member J [ Homo sapiens (human) ]

Gene ID: 142910, updated on 2-Nov-2024

Summary

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Official Symbol
LIPJprovided by HGNC
Official Full Name
lipase family member Jprovided by HGNC
Primary source
HGNC:HGNC:21773
See related
Ensembl:ENSG00000204022 MIM:613921; AllianceGenome:HGNC:21773
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LIPL1; bA425M17.2
Summary
Predicted to enable hydrolase activity, acting on ester bonds. Predicted to be involved in lipid catabolic process. Predicted to be active in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis (RPKM 1.7), thyroid (RPKM 0.3) and 20 other tissues See more
Orthologs
all
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Genomic context

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See LIPJ in Genome Data Viewer
Location:
10q23.31
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (88582907..88623184)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (89466981..89507284)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (90342664..90366733)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378416 Neighboring gene uncharacterized LOC101929727 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3720 Neighboring gene renalase, FAD dependent amine oxidase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3721 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3722 Neighboring gene vomeronasal 1 receptor 55 pseudogene Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:90107282-90107945 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3723 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3724 Neighboring gene ribosomal protein L7 pseudogene 34 Neighboring gene lipase F, gastric type Neighboring gene N-ethylmaleimide-sensitive factor attachment protein, gamma pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Homology

Clone Names

  • FLJ11218

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
lipase member J
Names
lipase J
lipase-like abhydrolase domain-containing protein 1
lipase-like, ab-hydrolase domain containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010939.3 → NP_001010939.2  lipase member J isoform 1

    See identical proteins and their annotated locations for NP_001010939.2

    Status: VALIDATED

    Source sequence(s)
    AL139406
    Consensus CDS
    CCDS31240.1
    UniProtKB/Swiss-Prot
    A8MT98, Q0P671, Q5W064
    Related
    ENSP00000361007.3, ENST00000371939.7
    Conserved Domains (3) summary
    pfam00561
    Location:48 → 347
    Abhydrolase_1; alpha/beta hydrolase fold
    pfam04083
    Location:3 → 66
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
    pfam12695
    Location:47 → 209
    Abhydrolase_5; Alpha/beta hydrolase family

  2. NM_001394640.1 → NP_001381569.1  lipase member J isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL139406
    Conserved Domains (1) summary
    PLN02872
    Location:4 → 310
    PLN02872; triacylglycerol lipase

RNA

  1. NR_172141.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL139406

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    88582907..88623184
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006717635.4 → XP_006717698.1  lipase member J isoform X1

    See identical proteins and their annotated locations for XP_006717698.1

    UniProtKB/Swiss-Prot
    A8MT98, Q0P671, Q5W064
    Conserved Domains (3) summary
    pfam00561
    Location:48 → 347
    Abhydrolase_1; alpha/beta hydrolase fold
    pfam04083
    Location:3 → 66
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
    pfam12695
    Location:47 → 209
    Abhydrolase_5; Alpha/beta hydrolase family

  2. XM_047424642.1 → XP_047280598.1  lipase member J isoform X2

  3. XM_047424643.1 → XP_047280599.1  lipase member J isoform X3

  4. XM_011539315.2 → XP_011537617.1  lipase member J isoform X1

    See identical proteins and their annotated locations for XP_011537617.1

    UniProtKB/Swiss-Prot
    A8MT98, Q0P671, Q5W064
    Conserved Domains (3) summary
    pfam00561
    Location:48 → 347
    Abhydrolase_1; alpha/beta hydrolase fold
    pfam04083
    Location:3 → 66
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
    pfam12695
    Location:47 → 209
    Abhydrolase_5; Alpha/beta hydrolase family

  5. XM_005269542.3 → XP_005269599.1  lipase member J isoform X4

    Conserved Domains (1) summary
    PLN02872
    Location:1 → 246
    PLN02872; triacylglycerol lipase

  6. XM_011539319.1 → XP_011537621.1  lipase member J isoform X6

    See identical proteins and their annotated locations for XP_011537621.1

    Conserved Domains (1) summary
    PLN02872
    Location:57 → 177
    PLN02872; triacylglycerol lipase

  7. XM_011539318.2 → XP_011537620.1  lipase member J isoform X5

    Conserved Domains (1) summary
    PLN02872
    Location:98 → 218
    PLN02872; triacylglycerol lipase

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    89466981..89507284
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054364875.1 → XP_054220850.1  lipase member J isoform X1

  2. XM_054364877.1 → XP_054220852.1  lipase member J isoform X2

  3. XM_054364878.1 → XP_054220853.1  lipase member J isoform X3

  4. XM_054364876.1 → XP_054220851.1  lipase member J isoform X1

  5. XM_054364879.1 → XP_054220854.1  lipase member J isoform X4

  6. XM_054364881.1 → XP_054220856.1  lipase member J isoform X6

  7. XM_054364880.1 → XP_054220855.1  lipase member J isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5W064.3 GenPept UniProtKB/Swiss-Prot:Q5W064

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