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Frk fyn-related kinase [ Mus musculus (house mouse) ]

Gene ID: 14302, updated on 2-Nov-2024

Summary

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Official Symbol
Frkprovided by MGI
Official Full Name
fyn-related kinaseprovided by MGI
Primary source
MGI:MGI:103265
See related
Ensembl:ENSMUSG00000019779 AllianceGenome:MGI:103265
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BSK; GTK; RAK; BSK/IYK
Summary
Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Predicted to be involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; innate immune response; and negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Orthologous to human FRK (fyn related Src family tyrosine kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in large intestine adult (RPKM 4.3), placenta adult (RPKM 3.4) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Frk in Genome Data Viewer
Location:
10 B1; 10 18.85 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (34359396..34487530)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (34483400..34611232)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26564 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:34017128-34017331 Neighboring gene TSPY-like 4 Neighboring gene 5'-nucleotidase domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_26275 Neighboring gene collagen, type X, alpha 1 Neighboring gene STARR-seq mESC enhancer starr_26277 Neighboring gene STARR-seq mESC enhancer starr_26278 Neighboring gene STARR-seq mESC enhancer starr_26279 Neighboring gene STARR-seq mESC enhancer starr_26280 Neighboring gene CWC22 spliceosome-associated protein homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_26281 Neighboring gene STARR-seq mESC enhancer starr_26282 Neighboring gene STARR-seq mESC enhancer starr_26283 Neighboring gene STARR-seq mESC enhancer starr_26284 Neighboring gene survival motor neuron 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. iyk, a novel intracellular protein tyrosine kinase differentially expressed in the mouse mammary gland and intestine. Thuveson M, et al. Biochem Biophys Res Commun, 1995 Apr 17. PMID 7733928
  2. Cloning of BSK, a murine FRK homologue with a specific pattern of tissue distribution. Oberg-Welsh C, et al. Gene, 1995 Jan 23. PMID 7835707
  3. Characterization of mice deficient in the Src family nonreceptor tyrosine kinase Frk/rak. Chandrasekharan S, et al. Mol Cell Biol, 2002 Jul. PMID 12077350, Free PMC Article
  4. Role of Fyn tyrosine kinase in ethanol consumption by mice. Cowen MS, et al. Alcohol Clin Exp Res, 2003 Aug. PMID 12966312
  5. The tyrosine kinase FRK/RAK participates in cytokine-induced islet cell cytotoxicity. Welsh M, et al. Biochem J, 2004 Aug 15. PMID 15186217, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results show that FRK affects beta cell number during embryogenesis and early in life, but is probably redundant for beta cell number and function in adult animals under normal conditions.
    Title: A role of FRK in regulation of embryonal pancreatic beta cell formation.
  2. The tyrosine kinases Brk/PTK6/Sik, Srm, Frk/Rak/Gtk/Iyk/Bsk, and Src42A/Dsrc41 have a low degree of sequence homology to other known kinases. The exon structure of these kinases, called the Brk family, is highly conserved and distinct.
    Title: Brk, Srm, Frk, and Src42A form a distinct family of intracellular Src-like tyrosine kinases.
  3. Characterization of mice deficient in the Src family nonreceptor tyrosine kinase Frk/rak. Decreases in the circulating levels of T3 but not T4 are reminiscent of euthyroid sick syndrome, a stress-associated clinical condition
    Title: Characterization of mice deficient in the Src family nonreceptor tyrosine kinase Frk/rak.
  4. Experiments with Fyn-deficient mice indicate that Fyn genotype does not influence ethanol consumption, neither under basal conditions nor following a deprivation period or stress.
    Title: Role of Fyn tyrosine kinase in ethanol consumption by mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (3)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tyrosine-protein kinase FRK
Names
B-cell src-homology tyrosine kinase
beta-cell Src-homology tyrosine kinase
intestine tyrosine kinase
NP_001153016.1
NP_001345698.1
NP_034367.2
XP_006512597.1
XP_006512599.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159544.1 → NP_001153016.1  tyrosine-protein kinase FRK

    See identical proteins and their annotated locations for NP_001153016.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longest transcript. Variants 1-3 all encode the same protein.
    Source sequence(s)
    AK052614, AK164460, AK166379, BP761286, CN665865, L36132
    Consensus CDS
    CCDS23781.1
    UniProtKB/Swiss-Prot
    Q61364, Q61745, Q922K9
    Related
    ENSMUSP00000130289.2, ENSMUST00000170771.3
    Conserved Domains (3) summary
    cd10369
    Location:119 → 214
    SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)
    cd11845
    Location:54 → 111
    SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
    cd05068
    Location:232 → 501
    PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases

  2. NM_001358769.1 → NP_001345698.1  tyrosine-protein kinase FRK

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 all encode the same protein.
    Source sequence(s)
    AC153960, AK052614, AK164460, BP761286
    Consensus CDS
    CCDS23781.1
    UniProtKB/Swiss-Prot
    Q61364, Q61745, Q922K9
    Conserved Domains (3) summary
    cd10369
    Location:119 → 214
    SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)
    cd11845
    Location:54 → 111
    SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
    cd05068
    Location:232 → 501
    PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases

  3. NM_010237.3 → NP_034367.2  tyrosine-protein kinase FRK

    See identical proteins and their annotated locations for NP_034367.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 all encode the same protein.
    Source sequence(s)
    AK028855, AK164460, AK166379, BP761286
    Consensus CDS
    CCDS23781.1
    UniProtKB/Swiss-Prot
    Q61364, Q61745, Q922K9
    Related
    ENSMUSP00000019913.8, ENSMUST00000019913.15
    Conserved Domains (3) summary
    cd10369
    Location:119 → 214
    SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)
    cd11845
    Location:54 → 111
    SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
    cd05068
    Location:232 → 501
    PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    34359396..34487530
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512534.5 → XP_006512597.1  tyrosine-protein kinase FRK isoform X1

    See identical proteins and their annotated locations for XP_006512597.1

    UniProtKB/Swiss-Prot
    Q61364, Q61745, Q922K9
    Conserved Domains (3) summary
    cd10369
    Location:119 → 214
    SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)
    cd11845
    Location:54 → 111
    SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
    cd05068
    Location:232 → 501
    PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases

  2. XM_006512536.5 → XP_006512599.1  tyrosine-protein kinase FRK isoform X1

    See identical proteins and their annotated locations for XP_006512599.1

    UniProtKB/Swiss-Prot
    Q61364, Q61745, Q922K9
    Conserved Domains (3) summary
    cd10369
    Location:119 → 214
    SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)
    cd11845
    Location:54 → 111
    SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
    cd05068
    Location:232 → 501
    PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q922K9.3 GenPept UniProtKB/Swiss-Prot:Q922K9

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