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MUC15 mucin 15, cell surface associated [ Homo sapiens (human) ]

Gene ID: 143662, updated on 5-Mar-2024

Summary

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Official Symbol
MUC15provided by HGNC
Official Full Name
mucin 15, cell surface associatedprovided by HGNC
Primary source
HGNC:HGNC:14956
See related
Ensembl:ENSG00000169550 MIM:608566; AllianceGenome:HGNC:14956
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAS3; MUC-15; PASIII
Summary
Predicted to be located in Golgi lumen and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thyroid (RPKM 49.6), skin (RPKM 13.7) and 5 other tissues See more
Orthologs
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Genomic context

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Location:
11p14.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (26559032..26572263, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (26699699..26712907, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (26580579..26593810, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene anoctamin 3 Neighboring gene ANO3 antisense RNA 1 Neighboring gene uncharacterized LOC105376598 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:26544561-26545120 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:26545121-26545680 Neighboring gene uncharacterized LOC124902648 Neighboring gene uncharacterized LOC107987160

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. High Expression of MUC15 Is Correlated with Poor Prognosis of Pancreatic Cancer and Promotes Migration, Invasion, and Chemo-Resistance In Vitro. Wang S, et al. Med Sci Monit, 2020 Oct 14. PMID 33051432, Free PMC Article
  2. Targeting MUC15 Protein in Cancer: Molecular Mechanisms and Therapeutic Perspectives. Zhang S, et al. Curr Cancer Drug Targets, 2020. PMID 32479243
  3. MUC15 inhibits cancer metastasis via PI3K/AKT signaling in renal cell carcinoma. Yue Y, et al. Cell Death Dis, 2020 May 7. PMID 32382053, Free PMC Article
  4. MUC15 promotes growth and invasion of glioma cells by activating Raf/MEK/ERK pathway. Cheng M, et al. Clin Exp Pharmacol Physiol, 2020 Jun. PMID 32031702
  5. Frameshift mutations of MUC15 gene in gastric and its regional heterogeneity in gastric and colorectal cancers. Oh HR, et al. Pathol Oncol Res, 2015 Jul. PMID 25573589

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cell surface associated protein mucin 15 (MUC15) is elevated in preeclampsia.
    Title: Cell surface associated protein mucin 15 (MUC15) is elevated in preeclampsia.
  2. Downregulation of MUC15 by miR-183-5p.1 promotes liver tumor-initiating cells properties and tumorigenesis via regulating c-MET/PI3K/AKT/SOX2 axis.
    Title: Downregulation of MUC15 by miR-183-5p.1 promotes liver tumor-initiating cells properties and tumorigenesis via regulating c-MET/PI3K/AKT/SOX2 axis.
  3. MUC15 loss facilitates epithelial-mesenchymal transition and cancer stemness for prostate cancer metastasis through GSK3beta/beta-catenin signaling.
    Title: MUC15 loss facilitates epithelial-mesenchymal transition and cancer stemness for prostate cancer metastasis through GSK3β/β-catenin signaling.
  4. Targeting MUC15 Protein in Cancer: Molecular Mechanisms and Therapeutic Perspectives.
    Title: Targeting MUC15 Protein in Cancer: Molecular Mechanisms and Therapeutic Perspectives.
  5. MUC15 promotes growth and invasion of glioma cells by activating Raf/MEK/ERK pathway.
    Title: MUC15 promotes growth and invasion of glioma cells by activating Raf/MEK/ERK pathway.
  6. High Expression of MUC15 Is Correlated with Poor Prognosis of Pancreatic Cancer and Promotes Migration, Invasion, and Chemo-Resistance In Vitro.
    Title: High Expression of MUC15 Is Correlated with Poor Prognosis of Pancreatic Cancer and Promotes Migration, Invasion, and Chemo-Resistance In Vitro.
  7. MUC15 inhibits cancer metastasis via PI3K/AKT signaling in renal cell carcinoma.
    Title: MUC15 inhibits cancer metastasis via PI3K/AKT signaling in renal cell carcinoma.
  8. Frameshift mutations of MUC15 gene is associated with gastric and colorectal cancers.
    Title: Frameshift mutations of MUC15 gene in gastric and its regional heterogeneity in gastric and colorectal cancers.
  9. Multivariate analysis suggested that MUC15 overexpression was an independent factor for prognosis (hazard risk: 3.216; P=0.009). It was concluded that MUC15 is overexpressed in glioma tissues.
    Title: Correlations of MUC15 overexpression with clinicopathological features and prognosis of glioma.
  10. MUC15 inhibits dimerization of EGFR and PI3K-AKT signaling and is associated with aggressive hepatocellular carcinomas in patients.
    Title: MUC15 inhibits dimerization of EGFR and PI3K-AKT signaling and is associated with aggressive hepatocellular carcinomas in patients.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common body mass index-associated variants confer risk of extreme obesity.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi lumen TAS
Traceable Author Statement
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
mucin-15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135091.2 → NP_001128563.1  mucin-15 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC036114, AY358668, BU676338, DA842986
    Consensus CDS
    CCDS44557.1
    UniProtKB/TrEMBL
    A0A0A0MT67
    Related
    ENSP00000431983.1, ENST00000529533.6
    Conserved Domains (1) summary
    pfam15672
    Location:47 → 361
    Mucin15; Cell-membrane associated Mucin15

  2. NM_001135092.2 → NP_001128564.1  mucin-15 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (c) is shorter than isoform a.
    Source sequence(s)
    AC036114, AJ507429, AY358668, BU676338, DA842986
    Consensus CDS
    CCDS44556.1
    UniProtKB/TrEMBL
    A0A0A0MTD6, A0A3B3IU37
    Related
    ENSP00000431945.1, ENST00000527569.1
    Conserved Domains (1) summary
    pfam15672
    Location:47 → 311
    Mucin15; Cell-membrane associated Mucin15

  3. NM_145650.4 → NP_663625.2  mucin-15 isoform b precursor

    See identical proteins and their annotated locations for NP_663625.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream translation initiation codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AC036114, AK128337, AY358668, BU676338, DA842986
    Consensus CDS
    CCDS7859.1
    UniProtKB/Swiss-Prot
    B3KY00, E9PII6, F8W945, Q6UWS3, Q8IXI8, Q8N387, Q8WW41
    Related
    ENSP00000397339.2, ENST00000455601.6
    Conserved Domains (1) summary
    pfam15672
    Location:20 → 334
    Mucin15; Cell-membrane associated Mucin15

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    26559032..26572263 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    26699699..26712907 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N387.2 GenPept UniProtKB/Swiss-Prot:Q8N387

Gene LinkOut

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