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FAM76B family with sequence similarity 76 member B [ Homo sapiens (human) ]

Gene ID: 143684, updated on 5-Mar-2024

Summary

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Official Symbol
FAM76Bprovided by HGNC
Official Full Name
family with sequence similarity 76 member Bprovided by HGNC
Primary source
HGNC:HGNC:28492
See related
Ensembl:ENSG00000077458 AllianceGenome:HGNC:28492
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Located in nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 14.3), lymph node (RPKM 9.9) and 24 other tissues See more
Orthologs
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Genomic context

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See FAM76B in Genome Data Viewer
Location:
11q21
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (95768953..95789782, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (95776343..95797175, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (95502117..95522946, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984377 Neighboring gene fibroblast growth factor receptor 3 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3851 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5417 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:95523907-95524570 Neighboring gene centrosomal protein 57 Neighboring gene RNA, 5S ribosomal pseudogene 345 Neighboring gene myotubularin related protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Production and Characterization of Monoclonal Antibodies against Human Nuclear Protein FAM76B. Zheng X, et al. PLoS One, 2016. PMID 27018871, Free PMC Article
  2. Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment. Salichs E, et al. PLoS Genet, 2009 Mar. PMID 19266028, Free PMC Article
  3. The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells. Vasilescu J, et al. J Proteome Res, 2007 Jan. PMID 17203973
  4. Identification of host proteins required for HIV infection through a functional genomic screen. Brass AL, et al. Science, 2008 Feb 15. PMID 18187620
  5. Histone-binding of DPF2 mediates its repressive role in myeloid differentiation. Huber FM, et al. Proc Natl Acad Sci U S A, 2017 Jun 6. PMID 28533407, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FAM76B regulates PI3K/Akt/NF-kappaB-mediated M1 macrophage polarization by influencing the stability of PIK3CD mRNA.
    Title: FAM76B regulates PI3K/Akt/NF-κB-mediated M1 macrophage polarization by influencing the stability of PIK3CD mRNA.
  2. FAM76B regulates NF-kappaB-mediated inflammatory pathway by influencing the translocation of hnRNPA2B1.
    Title: FAM76B regulates NF-κB-mediated inflammatory pathway by influencing the translocation of hnRNPA2B1.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of family with sequence similarity 76, member B (FAM76B) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC33371

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein FAM76B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330357.2 → NP_001317286.1  protein FAM76B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AI913200, AP001877, AW118814, BG718983, CN360040
    Consensus CDS
    CCDS81619.1
    UniProtKB/TrEMBL
    F5GX09
    Related
    ENSP00000441168.1, ENST00000536839.1
    Conserved Domains (1) summary
    pfam16046
    Location:6 → 327
    FAM76; FAM76 protein

  2. NM_144664.5 → NP_653265.3  protein FAM76B isoform 1

    See identical proteins and their annotated locations for NP_653265.3

    Status: VALIDATED

    Source sequence(s)
    AP001877, AW118814, BG718983, BX647586
    Consensus CDS
    CCDS41700.1
    UniProtKB/Swiss-Prot
    B2R9C2, Q5HYJ3, Q6PIU3, Q8TC53
    Related
    ENSP00000351631.5, ENST00000358780.10
    Conserved Domains (1) summary
    pfam16046
    Location:6 → 328
    FAM76; FAM76 protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    95768953..95789782 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426410.1 → XP_047282366.1  protein FAM76B isoform X1

  2. XM_011542610.3 → XP_011540912.1  protein FAM76B isoform X1

    See identical proteins and their annotated locations for XP_011540912.1

    Conserved Domains (1) summary
    pfam16046
    Location:4 → 302
    FAM76; FAM76 protein

  3. XM_047426411.1 → XP_047282367.1  protein FAM76B isoform X2

  4. XM_005273776.5 → XP_005273833.1  protein FAM76B isoform X1

    See identical proteins and their annotated locations for XP_005273833.1

    Conserved Domains (1) summary
    pfam16046
    Location:4 → 302
    FAM76; FAM76 protein

  5. XM_011542612.2 → XP_011540914.1  protein FAM76B isoform X3

    See identical proteins and their annotated locations for XP_011540914.1

    Conserved Domains (1) summary
    pfam16046
    Location:101 → 239
    FAM76; FAM76 protein

  6. XM_047426413.1 → XP_047282369.1  protein FAM76B isoform X4

  7. XM_047426412.1 → XP_047282368.1  protein FAM76B isoform X4

    Related
    ENSP00000444087.1, ENST00000543641.5

  8. XM_047426414.1 → XP_047282370.1  protein FAM76B isoform X5

RNA

  1. XR_007062451.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    95776343..95797175 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054367748.1 → XP_054223723.1  protein FAM76B isoform X1

  2. XM_054367747.1 → XP_054223722.1  protein FAM76B isoform X1

  3. XM_054367749.1 → XP_054223724.1  protein FAM76B isoform X2

  4. XM_054367750.1 → XP_054223725.1  protein FAM76B isoform X3

  5. XM_054367752.1 → XP_054223727.1  protein FAM76B isoform X4

  6. XM_054367751.1 → XP_054223726.1  protein FAM76B isoform X4

  7. XM_054367753.1 → XP_054223728.1  protein FAM76B isoform X5

RNA

  1. XR_008488343.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5HYJ3.3 GenPept UniProtKB/Swiss-Prot:Q5HYJ3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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