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CSF2RA colony stimulating factor 2 receptor subunit alpha [ Homo sapiens (human) ]

Gene ID: 1438, updated on 11-Apr-2024

Summary

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Official Symbol
CSF2RAprovided by HGNC
Official Full Name
colony stimulating factor 2 receptor subunit alphaprovided by HGNC
Primary source
HGNC:HGNC:2435
See related
Ensembl:ENSG00000198223 Ensembl:ENSG00000292357 MIM:306250; MIM:425000; AllianceGenome:HGNC:2435
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GMR; CD116; CSF2R; SMDP4; CDw116; CSF2RX; CSF2RY; GMCSFR; CSF2RAX; CSF2RAY; alphaGMR; GMR-alpha; GMCSFR-alpha; GM-CSF-R-alpha
Summary
The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. [provided by RefSeq, Jul 2008]
Expression
Broad expression in placenta (RPKM 20.8), appendix (RPKM 7.7) and 14 other tissues See more
Orthologs
all
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Genomic context

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Location:
X;Y
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (1268814..1325218)
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) Y NC_000024.10 (1268814..1325218)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (1116126..1174802)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) Y NC_060948.1 (1129416..1189240)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (1387707..1444111)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (1337707..1394111)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L6-like Neighboring gene hESC enhancers GRCh37_chrX:1324089-1324592, GRCh37_chrY:1274255-1275102 and GRCh37_chrY:1273405-1274254 Neighboring gene cytokine receptor like factor 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chrX:1367406-1367922 and GRCh37_chrY:1317424-1317933 Neighboring gene NANOG hESC enhancer GRCh37_chrY:1330085-1330594 Neighboring gene uncharacterized LOC124905238 Neighboring gene microRNA 3690 Neighboring gene RNA, 5S ribosomal pseudogene 498 Neighboring gene uncharacterized LOC101928032 Neighboring gene interleukin 3 receptor subunit alpha Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:1510270-1510865 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chrX:1510866-1511460 and GRCh37_chrY:1460904-1461506 Neighboring gene serine/arginine repetitive matrix protein 1-like Neighboring gene solute carrier family 25 member 6

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L6-like Neighboring gene hESC enhancers GRCh37_chrX:1324089-1324592, GRCh37_chrY:1274255-1275102 and GRCh37_chrY:1273405-1274254 Neighboring gene cytokine receptor like factor 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chrX:1367406-1367922 and GRCh37_chrY:1317424-1317933 Neighboring gene NANOG hESC enhancer GRCh37_chrY:1330085-1330594 Neighboring gene uncharacterized LOC124905238 Neighboring gene microRNA 3690 Neighboring gene RNA, 5S ribosomal pseudogene 498 Neighboring gene uncharacterized LOC101928032 Neighboring gene interleukin 3 receptor subunit alpha Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:1510270-1510865 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chrX:1510866-1511460 and GRCh37_chrY:1460904-1461506 Neighboring gene serine/arginine repetitive matrix protein 1-like Neighboring gene solute carrier family 25 member 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. CD116+ fetal precursors migrate to the perinatal lung and give rise to human alveolar macrophages. Evren E, et al. J Exp Med, 2022 Feb 7. PMID 35019940, Free PMC Article
  2. Characterization of CSF2RA mutation related juvenile pulmonary alveolar proteinosis. Hildebrandt J, et al. Orphanet J Rare Dis, 2014 Nov 26. PMID 25425184, Free PMC Article
  3. Initially lymphocytic Sweet's syndrome in male patients with myelodysplasia: a distinguished clinicopathological entity? Case report and systematic review of the literature. Kakaletsis N, et al. Acta Haematol, 2014. PMID 24714374
  4. Defective leukocyte GM-CSF receptor (CD116) expression and function in inflammatory bowel disease. Goldstein JI, et al. Gastroenterology, 2011 Jul. PMID 21557945, Free PMC Article
  5. Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA. Suzuki T, et al. J Exp Med, 2008 Nov 24. PMID 18955570, Free PMC Article

See all (77) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A murine model of hereditary pulmonary alveolar proteinosis caused by homozygous Csf2ra gene disruption.
    Title: A murine model of hereditary pulmonary alveolar proteinosis caused by homozygous Csf2ra gene disruption.
  2. CD116+ fetal precursors migrate to the perinatal lung and give rise to human alveolar macrophages.
    Title: CD116+ fetal precursors migrate to the perinatal lung and give rise to human alveolar macrophages.
  3. miR-532-3p-CSF2RA Axis as a Key Regulator of Vulnerable Atherosclerotic Plaque Formation.
    Title: miR-532-3p-CSF2RA Axis as a Key Regulator of Vulnerable Atherosclerotic Plaque Formation.
  4. Expression of granulocyte macrophage-colony stimulating factor and its receptor in the synovium of osteoarthritis patients is negatively correlated with pain.
    Title: Expression of granulocyte macrophage-colony stimulating factor and its receptor in the synovium of osteoarthritis patients is negatively correlated with pain.
  5. These data show that loss of membrane GM-CSFRalpha following GM-CSF exposure does not preclude sustained GM-CSF/GM-CSFRalpha signaling and that this receptor plays a key role in ligand clearance. Hence neutrophilic activation via GM-CSFR may play an important role in neutrophilic lung inflammation even in the absence of high GM-CSF levels or GM-CSFRalpha expression.
    Title: Neutrophil GM-CSF receptor dynamics in acute lung injury.
  6. Missense mutations in CSF2RA gene is associated with Pediatric Crohn's Disease.
    Title: Genetic and Transcriptomic Variation Linked to Neutrophil Granulocyte-Macrophage Colony-Stimulating Factor Signaling in Pediatric Crohn's Disease.
  7. Family-based whole genome analysis of a family with hereditary pulmonary alveolar proteinosis revealed a homozygous deletion that disrupts CSF2RA, CRLF2, and IL3RA gene in the pseudoautosomal region of the X chromosome in the affected child and one of asymptomatic siblings.
    Title: Whole-Genome Sequencing of a Family with Hereditary Pulmonary Alveolar Proteinosis Identifies a Rare Structural Variant Involving CSF2RA/CRLF2/IL3RA Gene Disruption.
  8. lesions from human secondary progressive multiple sclerosis, but not primary progressive multiple sclerosis patients shows extensive recruitment of GM-CSF Ralpha+ myeloid cells
    Title: Targeting the GM-CSF receptor for the treatment of CNS autoimmunity.
  9. Conformational changes in the GM-CSF receptor suggest a molecular mechanism for affinity conversion and receptor signaling.
    Title: Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling.
  10. regulatory molecule causative of aortic dissection and intramural haematoma
    Title: Granulocyte macrophage colony-stimulating factor is required for aortic dissection/intramural haematoma.
Submit: New GeneRIF Correction See all GeneRIFs (36)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Surfactant metabolism dysfunction, pulmonary, 4
MedGen: C2677877 OMIM: 300770 GeneReviews: Not available
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EBI GWAS Catalog

Description
Converging evidence for a pseudoautosomal cytokine receptor gene locus in schizophrenia.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of colony stimulating factor 2 receptor, alpha subunit (CSF2RA) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC3848, MGC4838

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in granulocyte-macrophage colony-stimulating factor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of leukocyte proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
part_of granulocyte macrophage colony-stimulating factor receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
granulocyte-macrophage colony-stimulating factor receptor subunit alpha
Names
CD116 antigen
GM-CSF receptor alpha subunit
alpha-GM-CSF receptor
colony stimulating factor 2 receptor alpha subunit
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
granulocyte-macrophage colony-stimulating factor receptor alpha chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012280.1 RefSeqGene

    Range
    5001..46136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_186

mRNA and Protein(s)

  1. NM_001161529.2 → NP_001155001.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform a precursor

    See identical proteins and their annotated locations for NP_001155001.1

    Status: REVIEWED

    Source sequence(s)
    BX649553
    Consensus CDS
    CCDS35191.1
    UniProtKB/Swiss-Prot
    A7J003, A8KAM1, B4DW68, J3JS76, J3JS77, O00207, P15509, Q14429, Q14430, Q14431, Q16564
    Related
    ENSP00000416437.2, ENSP00000518633.1, ENST00000432318.8, ENST00000711131.1
    Conserved Domains (2) summary
    pfam09240
    Location:123 → 215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    pfam18611
    Location:35 → 112
    IL3Ra_N; IL-3 receptor alpha chain N-terminal domain

  2. NM_001161530.2 → NP_001155002.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform f precursor

    See identical proteins and their annotated locations for NP_001155002.1

    Status: REVIEWED

    Source sequence(s)
    BX649553
    Consensus CDS
    CCDS55359.1
    UniProtKB/Swiss-Prot
    P15509
    Conserved Domains (2) summary
    pfam09240
    Location:123 → 215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    pfam18611
    Location:35 → 112
    IL3Ra_N; IL-3 receptor alpha chain N-terminal domain

  3. NM_001161531.2 → NP_001155003.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform g precursor

    See identical proteins and their annotated locations for NP_001155003.1

    Status: REVIEWED

    Source sequence(s)
    BX649553
    Consensus CDS
    CCDS55360.1
    UniProtKB/Swiss-Prot
    P15509
    Related
    ENSP00000370920.3, ENSP00000518632.1, ENST00000381509.8, ENST00000711220.1
    Conserved Domains (2) summary
    pfam09240
    Location:123 → 215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    pfam18611
    Location:35 → 112
    IL3Ra_N; IL-3 receptor alpha chain N-terminal domain

  4. NM_001161532.2 → NP_001155004.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform h

    See identical proteins and their annotated locations for NP_001155004.1

    Status: REVIEWED

    Source sequence(s)
    BX649553
    UniProtKB/Swiss-Prot
    P15509
    Conserved Domains (1) summary
    pfam09240
    Location:1 → 82
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

  5. NM_001379153.1 → NP_001366082.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform f precursor

    Status: REVIEWED

    Source sequence(s)
    BX649553
    Consensus CDS
    CCDS55359.1
    Conserved Domains (2) summary
    pfam09240
    Location:123 → 215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    pfam18611
    Location:35 → 112
    IL3Ra_N; IL-3 receptor alpha chain N-terminal domain

  6. NM_001379154.1 → NP_001366083.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform f precursor

    Status: REVIEWED

    Source sequence(s)
    BX649553
    Consensus CDS
    CCDS55359.1
    Related
    ENSP00000512483.1, ENSP00000518638.1, ENST00000498153.7, ENST00000711138.1
    Conserved Domains (2) summary
    pfam09240
    Location:123 → 215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    pfam18611
    Location:35 → 112
    IL3Ra_N; IL-3 receptor alpha chain N-terminal domain

  7. NM_001379155.1 → NP_001366084.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform g precursor

    Status: REVIEWED

    Source sequence(s)
    BX649553
    Consensus CDS
    CCDS55360.1
    Conserved Domains (2) summary
    pfam09240
    Location:123 → 215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    pfam18611
    Location:35 → 112
    IL3Ra_N; IL-3 receptor alpha chain N-terminal domain

  8. NM_001379156.1 → NP_001366085.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform a precursor

    Status: REVIEWED

    Source sequence(s)
    BX649553
    Consensus CDS
    CCDS35191.1
    UniProtKB/Swiss-Prot
    A7J003, A8KAM1, B4DW68, J3JS76, J3JS77, O00207, P15509, Q14429, Q14430, Q14431, Q16564
    Conserved Domains (2) summary
    pfam09240
    Location:123 → 215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    pfam18611
    Location:35 → 112
    IL3Ra_N; IL-3 receptor alpha chain N-terminal domain

  9. NM_001379158.1 → NP_001366087.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform a precursor

    Status: REVIEWED

    Source sequence(s)
    BX649553
    Consensus CDS
    CCDS35191.1
    UniProtKB/Swiss-Prot
    A7J003, A8KAM1, B4DW68, J3JS76, J3JS77, O00207, P15509, Q14429, Q14430, Q14431, Q16564
    Conserved Domains (2) summary
    pfam09240
    Location:123 → 215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    pfam18611
    Location:35 → 112
    IL3Ra_N; IL-3 receptor alpha chain N-terminal domain

  10. NM_001379159.1 → NP_001366088.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform i precursor

    Status: REVIEWED

    Source sequence(s)
    BX649553, BX901885
    Conserved Domains (2) summary
    pfam09240
    Location:123 → 215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    pfam18611
    Location:35 → 112
    IL3Ra_N; IL-3 receptor alpha chain N-terminal domain

  11. NM_001379160.1 → NP_001366089.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform j precursor

    Status: REVIEWED

    Source sequence(s)
    BX649553
    Conserved Domains (2) summary
    pfam09240
    Location:123 → 215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    pfam18611
    Location:35 → 112
    IL3Ra_N; IL-3 receptor alpha chain N-terminal domain

  12. NM_001379161.1 → NP_001366090.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform k precursor

    Status: REVIEWED

    Source sequence(s)
    BX649553, BX901885
    Conserved Domains (2) summary
    pfam09240
    Location:123 → 215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    pfam18611
    Location:35 → 112
    IL3Ra_N; IL-3 receptor alpha chain N-terminal domain

  13. NM_001379162.1 → NP_001366091.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform l precursor

    Status: REVIEWED

    Source sequence(s)
    BX649553, BX901885
    Conserved Domains (2) summary
    pfam09240
    Location:123 → 215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    pfam18611
    Location:35 → 112
    IL3Ra_N; IL-3 receptor alpha chain N-terminal domain

  14. NM_001379163.1 → NP_001366092.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform l precursor

    Status: REVIEWED

    Source sequence(s)
    BX649553, BX901885
    Conserved Domains (2) summary
    pfam09240
    Location:123 → 215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    pfam18611
    Location:35 → 112
    IL3Ra_N; IL-3 receptor alpha chain N-terminal domain

  15. NM_001379164.1 → NP_001366093.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform m precursor

    Status: REVIEWED

    Source sequence(s)
    BX649553, BX901885
    Conserved Domains (2) summary
    pfam09240
    Location:123 → 215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    pfam18611
    Location:35 → 112
    IL3Ra_N; IL-3 receptor alpha chain N-terminal domain

  16. NM_001379165.1 → NP_001366094.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform m precursor

    Status: REVIEWED

    Source sequence(s)
    BX649553, BX901885
    Conserved Domains (2) summary
    pfam09240
    Location:123 → 215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    pfam18611
    Location:35 → 112
    IL3Ra_N; IL-3 receptor alpha chain N-terminal domain

  17. NM_001379166.1 → NP_001366095.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform n precursor

    Status: REVIEWED

    Source sequence(s)
    BX649553
    Conserved Domains (2) summary
    pfam09240
    Location:123 → 215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    pfam18611
    Location:35 → 112
    IL3Ra_N; IL-3 receptor alpha chain N-terminal domain

  18. NM_001379167.1 → NP_001366096.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform c precursor

    Status: REVIEWED

    Source sequence(s)
    BX649553
    Consensus CDS
    CCDS35192.1
    UniProtKB/TrEMBL
    F2Z3C9
    Conserved Domains (2) summary
    pfam09240
    Location:123 → 215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    pfam18611
    Location:35 → 112
    IL3Ra_N; IL-3 receptor alpha chain N-terminal domain

  19. NM_001379168.1 → NP_001366097.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform c precursor

    Status: REVIEWED

    Source sequence(s)
    BX649553
    Consensus CDS
    CCDS35192.1
    UniProtKB/TrEMBL
    F2Z3C9
    Related
    ENSP00000370911.1, ENSP00000518627.1, ENST00000381500.6, ENST00000711226.1
    Conserved Domains (2) summary
    pfam09240
    Location:123 → 215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    pfam18611
    Location:35 → 112
    IL3Ra_N; IL-3 receptor alpha chain N-terminal domain

  20. NM_001379169.1 → NP_001366098.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform c precursor

    Status: REVIEWED

    Source sequence(s)
    BX649553
    Consensus CDS
    CCDS35192.1
    UniProtKB/TrEMBL
    F2Z3C9
    Conserved Domains (2) summary
    pfam09240
    Location:123 → 215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    pfam18611
    Location:35 → 112
    IL3Ra_N; IL-3 receptor alpha chain N-terminal domain

  21. NM_006140.6 → NP_006131.2  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform a precursor

    See identical proteins and their annotated locations for NP_006131.2

    Status: REVIEWED

    Source sequence(s)
    BX649553
    Consensus CDS
    CCDS35191.1
    UniProtKB/Swiss-Prot
    A7J003, A8KAM1, B4DW68, J3JS76, J3JS77, O00207, P15509, Q14429, Q14430, Q14431, Q16564
    Related
    ENSP00000370935.3, ENSP00000518637.1, ENST00000381524.8, ENST00000711137.1
    Conserved Domains (2) summary
    pfam09240
    Location:123 → 215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    pfam18611
    Location:35 → 112
    IL3Ra_N; IL-3 receptor alpha chain N-terminal domain

  22. NM_172245.4 → NP_758448.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform a precursor

    See identical proteins and their annotated locations for NP_758448.1

    Status: REVIEWED

    Source sequence(s)
    BX649553
    Consensus CDS
    CCDS35191.1
    UniProtKB/Swiss-Prot
    A7J003, A8KAM1, B4DW68, J3JS76, J3JS77, O00207, P15509, Q14429, Q14430, Q14431, Q16564
    Related
    ENSP00000370940.3, ENSP00000518635.1, ENST00000381529.9, ENST00000711129.1
    Conserved Domains (2) summary
    pfam09240
    Location:123 → 215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    pfam18611
    Location:35 → 112
    IL3Ra_N; IL-3 receptor alpha chain N-terminal domain

  23. NM_172246.4 → NP_758449.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform b precursor

    Status: REVIEWED

    Source sequence(s)
    BX649553
    Consensus CDS
    CCDS35190.1
    UniProtKB/Swiss-Prot
    P15509
    Related
    ENSP00000347606.3, ENSP00000518630.1, ENST00000355432.8, ENST00000711223.1
    Conserved Domains (2) summary
    smart00060
    Location:220 → 298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:121 → 215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

  24. NM_172247.3 → NP_758450.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform c precursor

    See identical proteins and their annotated locations for NP_758450.1

    Status: REVIEWED

    Source sequence(s)
    BX649553
    Consensus CDS
    CCDS35192.1
    UniProtKB/TrEMBL
    F2Z3C9
    Conserved Domains (2) summary
    pfam09240
    Location:123 → 215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    pfam18611
    Location:35 → 112
    IL3Ra_N; IL-3 receptor alpha chain N-terminal domain

  25. NM_172249.4 → NP_758452.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform e precursor

    See identical proteins and their annotated locations for NP_758452.1

    Status: REVIEWED

    Source sequence(s)
    BX649553
    Consensus CDS
    CCDS35193.1
    UniProtKB/TrEMBL
    J3JS74
    Related
    ENSP00000348058.2, ENSP00000518629.1, ENST00000355805.7, ENST00000711224.1
    Conserved Domains (1) summary
    pfam09240
    Location:121 → 215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

RNA

  1. NR_027760.3 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    BX649553
    Related
    ENST00000486791.6, ENST00000711225.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    1268814..1325218
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047441851.1 → XP_047297807.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X6

  2. XM_011546175.3 → XP_011544477.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X5

    See identical proteins and their annotated locations for XP_011544477.1

    UniProtKB/TrEMBL
    F2Z3C9
    Conserved Domains (2) summary
    pfam09240
    Location:123 → 215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    pfam18611
    Location:35 → 112
    IL3Ra_N; IL-3 receptor alpha chain N-terminal domain

  3. XM_047441850.1 → XP_047297806.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X2

  4. XM_011546167.3 → XP_011544469.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X2

    See identical proteins and their annotated locations for XP_011544469.1

    Conserved Domains (2) summary
    pfam09240
    Location:123 → 215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    pfam18611
    Location:35 → 112
    IL3Ra_N; IL-3 receptor alpha chain N-terminal domain

  5. XM_011546174.4 → XP_011544476.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X5

    See identical proteins and their annotated locations for XP_011544476.1

    UniProtKB/TrEMBL
    F2Z3C9
    Conserved Domains (2) summary
    pfam09240
    Location:123 → 215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    pfam18611
    Location:35 → 112
    IL3Ra_N; IL-3 receptor alpha chain N-terminal domain

  6. XM_047441853.1 → XP_047297809.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X5

  7. XM_047441846.1 → XP_047297802.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1

  8. XM_047441847.1 → XP_047297803.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1

  9. XM_047441845.1 → XP_047297801.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1

  10. XM_047441849.1 → XP_047297805.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X3

  11. XM_047441848.1 → XP_047297804.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1

  12. XM_047441852.1 → XP_047297808.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X4

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p14 Primary Assembly

    Range
    1268814..1325218
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442716.1 → XP_047298672.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X6

  2. XM_011545628.3 → XP_011543930.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X5

    See identical proteins and their annotated locations for XP_011543930.1

    UniProtKB/TrEMBL
    F2Z3C9
    Conserved Domains (2) summary
    pfam09240
    Location:123 → 215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    pfam18611
    Location:35 → 112
    IL3Ra_N; IL-3 receptor alpha chain N-terminal domain

  3. XM_047442715.1 → XP_047298671.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X2

  4. XM_011545620.3 → XP_011543922.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X2

    See identical proteins and their annotated locations for XP_011543922.1

    Conserved Domains (2) summary
    pfam09240
    Location:123 → 215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    pfam18611
    Location:35 → 112
    IL3Ra_N; IL-3 receptor alpha chain N-terminal domain

  5. XM_011545627.4 → XP_011543929.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X5

    See identical proteins and their annotated locations for XP_011543929.1

    UniProtKB/TrEMBL
    F2Z3C9
    Conserved Domains (2) summary
    pfam09240
    Location:123 → 215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    pfam18611
    Location:35 → 112
    IL3Ra_N; IL-3 receptor alpha chain N-terminal domain

  6. XM_047442718.1 → XP_047298674.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X5

  7. XM_047442711.1 → XP_047298667.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1

  8. XM_047442712.1 → XP_047298668.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1

  9. XM_047442710.1 → XP_047298666.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1

  10. XM_047442714.1 → XP_047298670.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X3

  11. XM_047442713.1 → XP_047298669.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1

  12. XM_047442717.1 → XP_047298673.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    1116126..1174802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326521.1 → XP_054182496.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X6

  2. XM_054326525.1 → XP_054182500.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X5

  3. XM_054326520.1 → XP_054182495.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X2

  4. XM_054326515.1 → XP_054182490.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X2

  5. XM_054326523.1 → XP_054182498.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X5

  6. XM_054326524.1 → XP_054182499.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X5

  7. XM_054326514.1 → XP_054182489.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1

  8. XM_054326516.1 → XP_054182491.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1

  9. XM_054326517.1 → XP_054182492.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1

  10. XM_054326519.1 → XP_054182494.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X3

  11. XM_054326518.1 → XP_054182493.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1

  12. XM_054326522.1 → XP_054182497.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060948.1 Alternate T2T-CHM13v2.0

    Range
    1129416..1189240
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054328251.1 → XP_054184226.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X5

  2. XM_054328247.1 → XP_054184222.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X2

  3. XM_054328242.1 → XP_054184217.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X2

  4. XM_054328249.1 → XP_054184224.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X5

  5. XM_054328250.1 → XP_054184225.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X5

  6. XM_054328241.1 → XP_054184216.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1

  7. XM_054328243.1 → XP_054184218.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1

  8. XM_054328244.1 → XP_054184219.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1

  9. XM_054328246.1 → XP_054184221.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X3

  10. XM_054328245.1 → XP_054184220.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1

  11. XM_054328248.1 → XP_054184223.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_172248.1: Suppressed sequence

    Description
    NM_172248.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P15509.1 GenPept UniProtKB/Swiss-Prot:P15509

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