U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CWF19L2 CWF19 like cell cycle control factor 2 [ Homo sapiens (human) ]

Gene ID: 143884, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
CWF19L2provided by HGNC
Official Full Name
CWF19 like cell cycle control factor 2provided by HGNC
Primary source
HGNC:HGNC:26508
See related
Ensembl:ENSG00000152404 AllianceGenome:HGNC:26508
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be part of post-mRNA release spliceosomal complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary (RPKM 6.7), endometrium (RPKM 5.9) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See CWF19L2 in Genome Data Viewer
Location:
11q22.3
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (107326360..107457825, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (107333512..107464989, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (107197086..107328551, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene argininosuccinate synthetase 1 pseudogene 13 Neighboring gene uncharacterized LOC105369477 Neighboring gene uncharacterized LOC124902745 Neighboring gene NANOG hESC enhancer GRCh37_chr11:107143023-107143770 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:107232171-107233370 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:107267561-107268760 Neighboring gene SMARCE1 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:107328330-107328835 Neighboring gene alkB homolog 8, tRNA methyltransferase Neighboring gene H3K27ac hESC enhancers GRCh37_chr11:107435812-107436330 and GRCh37_chr11:107436331-107436847 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5471 Neighboring gene SUCLG2 pseudogene 3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genome-wide analysis identifies 16q deletion associated with survival, molecular subtypes, mRNA expression, and germline haplotypes in breast cancer patients. Nordgard SH, et al. Genes Chromosomes Cancer, 2008 Aug. PMID 18398821
  2. BRCA2 mediates centrosome cohesion via an interaction with cytoplasmic dynein. Malik S, et al. Cell Cycle, 2016 Aug 17. PMID 27433848, Free PMC Article
  3. DNAJC17 is localized in nuclear speckles and interacts with splicing machinery components. Pascarella A, et al. Sci Rep, 2018 May 17. PMID 29773831, Free PMC Article
  4. Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage. Hill SJ, et al. Genes Dev, 2014 Sep 1. PMID 25184681, Free PMC Article
  5. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. Shimada M, et al. Hum Genet, 2010 Oct. PMID 20677014

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: An approach based on a genome-wide association study reveals candidate loci for narcolepsy.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ32343

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
part_of post-mRNA release spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
CWF19-like protein 2
Names
CWF19 like 2, cell cycle control

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152434.3 → NP_689647.2  CWF19-like protein 2

    See identical proteins and their annotated locations for NP_689647.2

    Status: VALIDATED

    Source sequence(s)
    AK126881, BX648704
    Consensus CDS
    CCDS8336.2
    UniProtKB/Swiss-Prot
    A4FU66, A4FU67, A4FU68, A8KAD6, Q2TBE0, Q6PHW1, Q96MI1
    Related
    ENSP00000282251.5, ENST00000282251.10
    Conserved Domains (2) summary
    pfam04676
    Location:795 → 889
    CwfJ_C_2; Protein similar to CwfJ C-terminus 2
    cl00228
    Location:662 → 786
    HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    107326360..107457825 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426419.1 → XP_047282375.1  CWF19-like protein 2 isoform X2

  2. XM_011542620.4 → XP_011540922.1  CWF19-like protein 2 isoform X1

RNA

  1. XR_007062452.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    107333512..107464989 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054367764.1 → XP_054223739.1  CWF19-like protein 2 isoform X2

  2. XM_054367763.1 → XP_054223738.1  CWF19-like protein 2 isoform X1

RNA

  1. XR_008488344.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2TBE0.4 GenPept UniProtKB/Swiss-Prot:Q2TBE0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous