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TTC36 tetratricopeptide repeat domain 36 [ Homo sapiens (human) ]

Gene ID: 143941, updated on 5-Mar-2024

Summary

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Official Symbol
TTC36provided by HGNC
Official Full Name
tetratricopeptide repeat domain 36provided by HGNC
Primary source
HGNC:HGNC:33708
See related
Ensembl:ENSG00000172425 MIM:620701; AllianceGenome:HGNC:33708
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HBP21
Summary
The protein encoded by this gene has three tetratricopeptide repeats and is a chaperone for heat shock protein 70. The encoded protein may function as a tumor suppressor in hepatocellular carcinoma (HCC) since it promotes apoptosis but is downregulated in HCC. [provided by RefSeq, Sep 2016]
Expression
Biased expression in liver (RPKM 51.1), kidney (RPKM 9.2) and 2 other tissues See more
Orthologs
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Genomic context

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See TTC36 in Genome Data Viewer
Location:
11q23.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (118527474..118530993)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (118546763..118550282)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (118398189..118401708)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100131626 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:118272182-118273045 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:118273504-118274094 Neighboring gene ATP synthase membrane subunit g Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr11:118306179-118307176 and GRCh37_chr11:118307177-118308175 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118308176-118309173 Neighboring gene Sharpr-MPRA regulatory region 11577 Neighboring gene lysine methyltransferase 2A Neighboring gene ReSE screen-validated silencer GRCh37_chr11:118358704-118358932 Neighboring gene TTC36 and KMT2A antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 12917 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3945 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3946 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3947 Neighboring gene transmembrane protein 25 Neighboring gene intraflagellar transport 46 Neighboring gene ribosomal protein L5 pseudogene 30

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Heat Shock-Binding Protein 21 Regulates the Innate Immune Response to Viral Infection. Xu Y, et al. J Virol, 2022 Apr 13. PMID 35254105, Free PMC Article
  2. HBP21: a novel member of TPR motif family, as a potential chaperone of heat shock protein 70 in proliferative vitreoretinopathy (PVR) and breast cancer. Liu Q, et al. Mol Biotechnol, 2008 Nov. PMID 18587674
  3. HBP21, a chaperone of heat shock protein 70, functions as a tumor suppressor in hepatocellular carcinoma. Jiang L, et al. Carcinogenesis, 2015 Oct. PMID 26246424
  4. HPD degradation regulated by the TTC36-STK33-PELI1 signaling axis induces tyrosinemia and neurological damage. Xie Y, et al. Nat Commun, 2019 Sep 19. PMID 31537781, Free PMC Article
  5. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? Nathan JA, et al. EMBO J, 2013 Feb 20. PMID 23314748, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Heat Shock-Binding Protein 21 Regulates the Innate Immune Response to Viral Infection.
    Title: Heat Shock-Binding Protein 21 Regulates the Innate Immune Response to Viral Infection.
  2. As a chaperone of heat shock protein 70 (HSP70), HBP21 could inhibit interaction between HSP70 and Bax, increased Bax protein translocation from cytoplasm to mitochondria.
    Title: HBP21, a chaperone of heat shock protein 70, functions as a tumor suppressor in hepatocellular carcinoma.
  3. The newly discovered interaction between HBP21 and Hsp70 suggests that HBP21 may be involved in the inhibition of progression and metastasis of tumor cells.
    Title: HBP21: a novel member of TPR motif family, as a potential chaperone of heat shock protein 70 in proliferative vitreoretinopathy (PVR) and breast cancer.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in central nervous system neuron development IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in memory IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of peptidyl-threonine phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein polyubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in tyrosine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in visual learning IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tetratricopeptide repeat protein 36
Names
HSP70 binding protein 21
TPR repeat protein 36

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080441.4 → NP_001073910.1  tetratricopeptide repeat protein 36 isoform a

    See identical proteins and their annotated locations for NP_001073910.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    BC146916, EU489483
    Consensus CDS
    CCDS31687.1
    UniProtKB/Swiss-Prot
    A6NLP5, B7ZW72, B9EJD8
    Related
    ENSP00000307640.4, ENST00000302783.10
    Conserved Domains (2) summary
    sd00006
    Location:51 → 79
    TPR; TPR repeat [structural motif]
    cl26005
    Location:80 → 154
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

  2. NM_001346096.2 → NP_001333025.1  tetratricopeptide repeat protein 36 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    BC171913
    UniProtKB/Swiss-Prot
    A6NLP5
    Conserved Domains (2) summary
    sd00006
    Location:25 → 55
    TPR; TPR repeat [structural motif]
    cl26005
    Location:21 → 95
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

  3. NM_001346097.2 → NP_001333026.1  tetratricopeptide repeat protein 36 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    BC171906
    UniProtKB/Swiss-Prot
    A6NLP5
    Conserved Domains (2) summary
    sd00006
    Location:25 → 55
    TPR; TPR repeat [structural motif]
    cl26005
    Location:21 → 95
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

  4. NM_001346098.2 → NP_001333027.1  tetratricopeptide repeat protein 36 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AP000941, AW027968
    UniProtKB/Swiss-Prot
    A6NLP5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    118527474..118530993
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    118546763..118550282
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NLP5.1 GenPept UniProtKB/Swiss-Prot:A6NLP5

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