U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

E2F7 E2F transcription factor 7 [ Homo sapiens (human) ]

Gene ID: 144455, updated on 3-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
E2F7provided by HGNC
Official Full Name
E2F transcription factor 7provided by HGNC
Primary source
HGNC:HGNC:23820
See related
Ensembl:ENSG00000165891 MIM:612046; AllianceGenome:HGNC:23820
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables DNA-binding transcription repressor activity; cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of transcription by RNA polymerase II; and sprouting angiogenesis. Located in nuclear speck. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis (RPKM 1.6), bone marrow (RPKM 1.5) and 16 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See E2F7 in Genome Data Viewer
Location:
12q21.2
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (77021251..77065569, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (76999082..77043421, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (77415031..77459349, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902971 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4674 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4675 Neighboring gene cysteine and glycine rich protein 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:77313616-77314124 Neighboring gene Sharpr-MPRA regulatory region 9474 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:77329846-77331045 Neighboring gene NANOG hESC enhancer GRCh37_chr12:77358407-77359020 Neighboring gene RAN binding protein 1 pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:77425832-77427031 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6681 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6682 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6683 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4676 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr12:77459297-77460003 Neighboring gene Sharpr-MPRA regulatory region 14502 Neighboring gene uncharacterized LOC105369853 Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. E2F7 can regulate proliferation, differentiation, and apoptotic responses in human keratinocytes: implications for cutaneous squamous cell carcinoma formation. Endo-Munoz L, et al. Cancer Res, 2009 Mar 1. PMID 19223542
  2. Role and mechanism of circ-PRKCI in hepatocellular carcinoma. Qi SX, et al. World J Gastroenterol, 2019 Apr 28. PMID 31086464, Free PMC Article
  3. E2F7, regulated by miR‑30c, inhibits apoptosis and promotes cell cycle of prostate cancer cells. Wang Y, et al. Oncol Rep, 2020 Sep. PMID 32582990, Free PMC Article
  4. Clinical relevance of E2F family members in ovarian cancer--an evaluation in a training set of 77 patients. Reimer D, et al. Clin Cancer Res, 2007 Jan 1. PMID 17200349
  5. Loss of E2F7 confers resistance to poly-ADP-ribose polymerase (PARP) inhibitors in BRCA2-deficient cells. Clements KE, et al. Nucleic Acids Res, 2018 Sep 28. PMID 30032296, Free PMC Article

See all (102) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The novel circFKBP8/miR-432-5p/E2F7 cascade functions as a regulatory network in breast cancer.
    Title: The novel circFKBP8/miR-432-5p/E2F7 cascade functions as a regulatory network in breast cancer.
  2. Transcription Factor E2F7 Hampers the Killing Effect of NK Cells against Colorectal Cancer Cells via Activating RAD18 Transcription.
    Title: Transcription Factor E2F7 Hampers the Killing Effect of NK Cells against Colorectal Cancer Cells via Activating RAD18 Transcription.
  3. p53/E2F7 axis promotes temozolomide chemoresistance in glioblastoma multiforme.
    Title: p53/E2F7 axis promotes temozolomide chemoresistance in glioblastoma multiforme.
  4. E2F7 serves as a potential prognostic biomarker for lung adenocarcinoma.
    Title: E2F7 serves as a potential prognostic biomarker for lung adenocarcinoma.
  5. CISD2 transcriptional activated by transcription factor E2F7 promotes the malignant progression of cervical cancer.
    Title: CISD2 transcriptional activated by transcription factor E2F7 promotes the malignant progression of cervical cancer.
  6. Circ_0010235 confers cisplatin resistance in lung cancer by upregulating E2F7 through absorbing miR-379-5p.
    Title: Circ_0010235 confers cisplatin resistance in lung cancer by upregulating E2F7 through absorbing miR-379-5p.
  7. E2F7 drives autotaxin/Enpp2 transcription via chromosome looping: Repression by p53 in murine but not in human carcinomas.
    Title: E2F7 drives autotaxin/Enpp2 transcription via chromosome looping: Repression by p53 in murine but not in human carcinomas.
  8. VIRMA promotes nasopharyngeal carcinoma, tumorigenesis, and metastasis by upregulation of E2F7 in an m6A-dependent manner.
    Title: VIRMA promotes nasopharyngeal carcinoma, tumorigenesis, and metastasis by upregulation of E2F7 in an m6A-dependent manner.
  9. lncRNA ENST00000585827 Contributes to the Progression of Endometrial Carcinoma via Regulating miR-424/E2F6/E2F7 Axis.
    Title: lncRNA ENST00000585827 Contributes to the Progression of Endometrial Carcinoma via Regulating miR-424/E2F6/E2F7 Axis.
  10. Circular RNA hsa_circ_0000519 contributes to angiogenesis and tumor progression in hepatocellular carcinoma through the miR-1296/E2F7 axis.
    Title: Circular RNA hsa_circ_0000519 contributes to angiogenesis and tumor progression in hepatocellular carcinoma through the miR-1296/E2F7 axis.
Submit: New GeneRIF Correction See all GeneRIFs (55)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of ancestry-specific TB risk in the South African Coloured population.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ12981

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables DNA-binding transcription repressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription repressor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chorionic trophoblast cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in hepatocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of G1/S transition of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cytokinesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in placenta development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of DNA endoreduplication ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in trophoblast giant cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in nuclear speck IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  

General protein information

Go to the top of the page Help
Preferred Names
transcription factor E2F7
Names
E2F-7

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_203394.3 → NP_976328.2  transcription factor E2F7

    See identical proteins and their annotated locations for NP_976328.2

    Status: VALIDATED

    Source sequence(s)
    AC025161, AI380315, AK097677, BC017481, DB159890
    Consensus CDS
    CCDS9016.1
    UniProtKB/Swiss-Prot
    A6NC74, B2RMR7, B3KTZ5, B3KUP8, B5MED9, Q96AV8
    Related
    ENSP00000323246.7, ENST00000322886.12
    Conserved Domains (1) summary
    pfam02319
    Location:144 → 211
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    77021251..77065569 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537966.3 → XP_011536268.1  transcription factor E2F7 isoform X1

    Conserved Domains (1) summary
    pfam02319
    Location:144 → 211
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain

  2. XM_011537969.3 → XP_011536271.1  transcription factor E2F7 isoform X2

    Conserved Domains (1) summary
    pfam02319
    Location:43 → 110
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    76999082..77043421 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054371191.1 → XP_054227166.1  transcription factor E2F7 isoform X1

  2. XM_054371192.1 → XP_054227167.1  transcription factor E2F7 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96AV8.3 GenPept UniProtKB/Swiss-Prot:Q96AV8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous