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Gcgr glucagon receptor [ Mus musculus (house mouse) ]

Gene ID: 14527, updated on 28-Oct-2024

Summary

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Official Symbol
Gcgrprovided by MGI
Official Full Name
glucagon receptorprovided by MGI
Primary source
MGI:MGI:99572
See related
Ensembl:ENSMUSG00000025127 AllianceGenome:MGI:99572
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GR
Summary
Enables glucagon receptor activity. Involved in several processes, including cellular response to glucagon stimulus; glucose homeostasis; and regulation of glycogen metabolic process. Acts upstream of or within cellular response to starvation and positive regulation of gene expression. Is active in plasma membrane. Is expressed in several structures, including brain; foot mesenchyme; gut; liver; and male reproductive gland or organ. Used to study Mahvash Disease. Human ortholog(s) of this gene implicated in Mahvash Disease and type 2 diabetes mellitus. Orthologous to human GCGR (glucagon receptor). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in liver adult (RPKM 145.3), liver E18 (RPKM 21.1) and 4 other tissues See more
Orthologs
human all
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Genomic context

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See Gcgr in Genome Data Viewer
Location:
11 E2; 11 84.24 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120420011..120429815)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120529185..120538989)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39490 Neighboring gene predicted gene, 53658 Neighboring gene STARR-positive B cell enhancer ABC_E11502 Neighboring gene MAPK regulated corepressor interacting protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E8476 Neighboring gene protein phosphatase 1, regulatory subunit 27

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes. Yang J, et al. BMC Genomics, 2011 Jun 1. PMID 21631939, Free PMC Article
  2. Loss of glucagon signaling alters white adipose tissue browning. Townsend LK, et al. FASEB J, 2019 Apr. PMID 30615494
  3. Disruption of glucagon receptor signaling causes hyperaminoacidemia exposing a possible liver-alpha-cell axis. Galsgaard KD, et al. Am J Physiol Endocrinol Metab, 2018 Jan 1. PMID 28978545, Free PMC Article
  4. Exocrine pancreas hyperplasia without dysplasia in glucagon receptor knockout mice. Yu R, et al. Pancreas, 2014 Jan. PMID 24326371
  5. Oxyntomodulin increases intrinsic heart rate through the glucagon receptor. Mukharji A, et al. Physiol Rep, 2013 Oct. PMID 24303183, Free PMC Article

See all (120) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Downregulation of the kidney glucagon receptor, essential for renal function and systemic homeostasis, contributes to chronic kidney disease.
    Title: Downregulation of the kidney glucagon receptor, essential for renal function and systemic homeostasis, contributes to chronic kidney disease.
  2. Loss of endothelial glucocorticoid receptor accelerates organ fibrosis in db/db mice.
    Title: Loss of endothelial glucocorticoid receptor accelerates organ fibrosis in db/db mice.
  3. Glucagon receptor blockage inhibits beta-cell dedifferentiation through FoxO1.
    Title: Glucagon receptor blockage inhibits β-cell dedifferentiation through FoxO1.
  4. Glucagon receptor antagonism impairs and glucagon receptor agonism enhances triglycerides metabolism in mice.
    Title: Glucagon receptor antagonism impairs and glucagon receptor agonism enhances triglycerides metabolism in mice.
  5. Glucagon receptor signaling at white adipose tissue does not regulate lipolysis.
    Title: Glucagon receptor signaling at white adipose tissue does not regulate lipolysis.
  6. Intestinal Growth in Glucagon Receptor Knockout Mice Is Not Associated With the Formation of AOM/DSS-Induced Tumors.
    Title: Intestinal Growth in Glucagon Receptor Knockout Mice Is Not Associated With the Formation of AOM/DSS-Induced Tumors.
  7. Glucagon blockade restores functional beta-cell mass in type 1 diabetic mice and enhances function of human islets.
    Title: Glucagon blockade restores functional β-cell mass in type 1 diabetic mice and enhances function of human islets.
  8. The 14-3-3 protein YWHAB inhibits glucagon-induced hepatic gluconeogenesis through interacting with the glucagon receptor and FOXO1.
    Title: The 14-3-3 protein YWHAB inhibits glucagon-induced hepatic gluconeogenesis through interacting with the glucagon receptor and FOXO1.
  9. Glucagon receptor antagonism promotes the production of gut proglucagon-derived peptides in diabetic mice.
    Title: Glucagon receptor antagonism promotes the production of gut proglucagon-derived peptides in diabetic mice.
  10. Both glucagon-receptor signaling and insulin-receptor signaling mutually contribute to blood glucose homeostasis and amino acid metabolism in mice. Glucagon receptor antagonism increased amino acids, lowered glycemia, and increased glucagon but did not influence insulin concentrations.
    Title: Glucose and amino acid metabolism in mice depend mutually on glucagon and insulin receptor signaling.
Submit: New GeneRIF Correction See all GeneRIFs (45)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glucagon receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucagon receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glucagon receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables glucagon receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables peptide hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide hormone binding IEA
Inferred from Electronic Annotation
more info
  
enables peptide hormone binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to glucagon stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to glucagon stimulus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hormone-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in hormone-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of glycogen metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
glucagon receptor
Names
GL-R

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001431129.1 → NP_001418058.1  glucagon receptor isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL669855

  2. NM_008101.3 → NP_032127.2  glucagon receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_032127.2

    Status: VALIDATED

    Source sequence(s)
    AL669855
    Consensus CDS
    CCDS25739.1
    UniProtKB/Swiss-Prot
    Q61606, Q63960, Q8K0B5
    UniProtKB/TrEMBL
    Q3UN81
    Related
    ENSMUSP00000026119.8, ENSMUST00000026119.8
    Conserved Domains (2) summary
    cd15267
    Location:137 → 417
    7tmB1_GCGR; glucagon receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
    pfam02793
    Location:56 → 125
    HRM; Hormone receptor domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    120420011..120429815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314269.2 → XP_017169758.1  glucagon receptor isoform X5

    UniProtKB/TrEMBL
    Q3UN81
    Conserved Domains (1) summary
    cd15267
    Location:143 → 373
    7tmB1_GCGR; glucagon receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

  2. XM_017314267.2 → XP_017169756.1  glucagon receptor isoform X3

    UniProtKB/TrEMBL
    Q3UN81
    Conserved Domains (1) summary
    cd15267
    Location:149 → 420
    7tmB1_GCGR; glucagon receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

  3. XM_017314263.2 → XP_017169752.1  glucagon receptor isoform X1

    UniProtKB/TrEMBL
    Q3UN81
    Conserved Domains (1) summary
    cd15267
    Location:149 → 429
    7tmB1_GCGR; glucagon receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

  4. XM_017314265.2 → XP_017169754.1  glucagon receptor isoform X1

    UniProtKB/TrEMBL
    Q3UN81
    Conserved Domains (1) summary
    cd15267
    Location:149 → 429
    7tmB1_GCGR; glucagon receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

  5. XM_017314268.2 → XP_017169757.1  glucagon receptor isoform X4

    UniProtKB/TrEMBL
    Q3UN81
    Conserved Domains (2) summary
    cd15267
    Location:108 → 388
    7tmB1_GCGR; glucagon receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
    pfam02793
    Location:27 → 96
    HRM; Hormone receptor domain

  6. XM_036156335.1 → XP_036012228.1  glucagon receptor isoform X6

    Conserved Domains (1) summary
    cd15267
    Location:1 → 280
    7tmB1_GCGR; glucagon receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

  7. XM_017314266.1 → XP_017169755.1  glucagon receptor isoform X2

    UniProtKB/Swiss-Prot
    Q61606, Q63960, Q8K0B5
    UniProtKB/TrEMBL
    Q3UN81
    Conserved Domains (2) summary
    cd15267
    Location:137 → 417
    7tmB1_GCGR; glucagon receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
    pfam02793
    Location:56 → 125
    HRM; Hormone receptor domain

  8. XM_006532216.4 → XP_006532279.1  glucagon receptor isoform X6

    Related
    ENSMUST00000147877.8
    Conserved Domains (1) summary
    cd15267
    Location:1 → 280
    7tmB1_GCGR; glucagon receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

  9. XM_030245567.1 → XP_030101427.1  glucagon receptor isoform X6

    Conserved Domains (1) summary
    cd15267
    Location:1 → 280
    7tmB1_GCGR; glucagon receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

  10. XM_006532217.2 → XP_006532280.1  glucagon receptor isoform X7

    Conserved Domains (2) summary
    cd14964
    Location:5 → 32
    7tm_GPCRs; TM helix 3 [structural motif]
    cl28897
    Location:1 → 196
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61606.2 GenPept UniProtKB/Swiss-Prot:Q61606

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