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LRRC74A leucine rich repeat containing 74A [ Homo sapiens (human) ]

Gene ID: 145497, updated on 5-Mar-2024

Summary

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Official Symbol
LRRC74Aprovided by HGNC
Official Full Name
leucine rich repeat containing 74Aprovided by HGNC
Primary source
HGNC:HGNC:23346
See related
Ensembl:ENSG00000100565 AllianceGenome:HGNC:23346
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LRRC74; C14orf166B
Expression
Restricted expression toward testis (RPKM 2.8) See more
Orthologs
mouse all
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Genomic context

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Location:
14q24.3
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (76826408..76870304)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (71036112..71080030)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (77292751..77336647)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5957 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5958 Neighboring gene vasohibin 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:77241882-77242840 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8772 Neighboring gene VASH1 antisense RNA 1 Neighboring gene angel homolog 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:77278266-77278840 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:77278841-77279414 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:77288377-77289157 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:77294675-77295362 Neighboring gene Sharpr-MPRA regulatory region 2360 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:77350573-77351390 Neighboring gene RN7SK pseudogene 17 Neighboring gene ribosomal protein L22 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614, Free PMC Article
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  3. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

General protein information

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Preferred Names
leucine-rich repeat-containing protein 74A
Names
leucine rich repeat containing 74
leucine-rich repeat-containing protein 74

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001385106.1 → NP_001372035.1  leucine-rich repeat-containing protein 74A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AF111169
    Consensus CDS
    CCDS91911.1
    UniProtKB/TrEMBL
    A0A8I5KUZ3, A0A8I5KW16
    Related
    ENSP00000509938.1, ENST00000689127.1
    Conserved Domains (2) summary
    sd00033
    Location:119 → 141
    LRR_RI; leucine-rich repeat [structural motif]
    cl39015
    Location:95 → 351
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  2. NM_001385107.1 → NP_001372036.1  leucine-rich repeat-containing protein 74A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AF111169
    Conserved Domains (2) summary
    sd00033
    Location:119 → 141
    LRR_RI; leucine-rich repeat [structural motif]
    cl39015
    Location:95 → 344
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  3. NM_001385108.1 → NP_001372037.1  leucine-rich repeat-containing protein 74A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AF111169
    Consensus CDS
    CCDS91912.1
    UniProtKB/TrEMBL
    A0A8I5KUH5
    Related
    ENSP00000509131.1, ENST00000691684.1
    Conserved Domains (2) summary
    sd00033
    Location:119 → 141
    LRR_RI; leucine-rich repeat [structural motif]
    cl39015
    Location:95 → 307
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  4. NM_194287.3 → NP_919263.2  leucine-rich repeat-containing protein 74A isoform 1

    See identical proteins and their annotated locations for NP_919263.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AF111169, BC121159, DB337977, DC397584
    Consensus CDS
    CCDS9853.2
    UniProtKB/Swiss-Prot
    Q0VAA2, Q6ZUG6, Q9Y627
    Related
    ENSP00000377369.3, ENST00000393774.7
    Conserved Domains (2) summary
    sd00033
    Location:136 → 158
    LRR_RI; leucine-rich repeat [structural motif]
    cl42388
    Location:112 → 368
    PPP1R42; protein phosphatase 1 regulatory subunit 42

RNA

  1. NR_169572.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AF111169
    Related
    ENST00000484640.6

  2. NR_169573.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AF111169
    Related
    ENST00000216450.7

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    76826408..76870304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021035.3 → XP_016876524.1  leucine-rich repeat-containing protein 74A isoform X1

  2. XM_047431012.1 → XP_047286968.1  leucine-rich repeat-containing protein 74A isoform X2

  3. XM_047431013.1 → XP_047286969.1  leucine-rich repeat-containing protein 74A isoform X3

  4. XM_047431014.1 → XP_047286970.1  leucine-rich repeat-containing protein 74A isoform X4

    Related
    ENST00000557453.6

  5. XM_047431015.1 → XP_047286971.1  leucine-rich repeat-containing protein 74A isoform X6

  6. XM_011536487.2 → XP_011534789.2  leucine-rich repeat-containing protein 74A isoform X5

  7. XM_047431016.1 → XP_047286972.1  leucine-rich repeat-containing protein 74A isoform X7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    71036112..71080030
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054375466.1 → XP_054231441.1  leucine-rich repeat-containing protein 74A isoform X1

  2. XM_054375467.1 → XP_054231442.1  leucine-rich repeat-containing protein 74A isoform X2

  3. XM_054375468.1 → XP_054231443.1  leucine-rich repeat-containing protein 74A isoform X3

  4. XM_054375469.1 → XP_054231444.1  leucine-rich repeat-containing protein 74A isoform X4

  5. XM_054375471.1 → XP_054231446.1  leucine-rich repeat-containing protein 74A isoform X6

  6. XM_054375470.1 → XP_054231445.1  leucine-rich repeat-containing protein 74A isoform X5

  7. XM_054375472.1 → XP_054231447.1  leucine-rich repeat-containing protein 74A isoform X7

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0VAA2.2 GenPept UniProtKB/Swiss-Prot:Q0VAA2

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