Gdnf glial cell line derived neurotrophic factor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gdnfprovided by MGI
Official Full Name: glial cell line derived neurotrophic factorprovided by MGI
Primary source: MGI:MGI:107430
See related: Ensembl:ENSMUSG00000022144 AllianceGenome:MGI:107430
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ATF
Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Homozygous knockout mice for this gene exhibit defects in kidney development and neonatal death. This gene encodes multiple protein isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]
Expression: Broad expression in lung adult (RPKM 1.6), ovary adult (RPKM 1.5) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 A1; 15 3.8 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (7839529..7867061)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (7810048..7837580)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Muscle-resident mesenchymal progenitors sense and repair peripheral nerve injury via the GDNF-BDNF axis.
Title: Muscle-resident mesenchymal progenitors sense and repair peripheral nerve injury via the GDNF-BDNF axis.
Astrocytic GDNF ameliorates anesthesia and surgery-induced cognitive impairment by promoting hippocampal synaptic plasticity in aged mice.
Title: Astrocytic GDNF ameliorates anesthesia and surgery-induced cognitive impairment by promoting hippocampal synaptic plasticity in aged mice.
Environmental enrichment accentuates glucose-induced feeding suppression and glial cell line-derived neurotrophic factor gene expression in the hypothalamus of mice.
Title: Environmental enrichment accentuates glucose-induced feeding suppression and glial cell line-derived neurotrophic factor gene expression in the hypothalamus of mice.
Functional role of glial-derived neurotrophic factor in a mixed allergen murine model of asthma.
Title: Functional role of glial-derived neurotrophic factor in a mixed allergen murine model of asthma.
Glial cell derived neurotrophic factor prevents western diet and palmitate-induced hepatocyte oxidative damage and death through SIRT3.
Title: Glial cell derived neurotrophic factor prevents western diet and palmitate-induced hepatocyte oxidative damage and death through SIRT3.
Overexpression of Brain- and Glial Cell Line-Derived Neurotrophic Factors Is Neuroprotective in an Animal Model of Acute Hypobaric Hypoxia.
Title: Overexpression of Brain- and Glial Cell Line-Derived Neurotrophic Factors Is Neuroprotective in an Animal Model of Acute Hypobaric Hypoxia.
Astrocytic SARM1 promotes neuroinflammation and axonal demyelination in experimental autoimmune encephalomyelitis through inhibiting GDNF signaling.
Title: Astrocytic SARM1 promotes neuroinflammation and axonal demyelination in experimental autoimmune encephalomyelitis through inhibiting GDNF signaling.
Bimodal regulation of axonal transport by the GDNF-RET signalling axis in healthy and diseased motor neurons.
Title: Bimodal regulation of axonal transport by the GDNF-RET signalling axis in healthy and diseased motor neurons.
Tumoral Neuroligin 1 Promotes Cancer-Nerve Interactions and Synergizes with the Glial Cell Line-Derived Neurotrophic Factor.
Title: Tumoral Neuroligin 1 Promotes Cancer-Nerve Interactions and Synergizes with the Glial Cell Line-Derived Neurotrophic Factor.
Boosting effect of testosterone on GDNF expression in Sertoli cell line (TM4); comparison between TM3 cells-produced and exogenous testosterone.
Title: Boosting effect of testosterone on GDNF expression in Sertoli cell line (TM4); comparison between TM3 cells-produced and exogenous testosterone.

Submit: New GeneRIF Correction See all GeneRIFs (157)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (8) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:492837

Gdnf (e-PCR), detects polymorphism
- UniSTS:234030

NoName (e-PCR)
- UniSTS:481584

PMC186320P2 (e-PCR)
- UniSTS:271697

PMC186320P3 (e-PCR)
- UniSTS:271698

Gdnf (e-PCR), detects polymorphism
- UniSTS:143191

Gdnf (e-PCR), detects polymorphism
- UniSTS:143192

Gdnf (e-PCR), detects polymorphism
- UniSTS:497281

GDNF_3150 (e-PCR)
- UniSTS:462211

AI385739 (e-PCR)
- UniSTS:180731

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables glial cell-derived neurotrophic factor receptor binding	IEA Inferred from Electronic Annotation more info
enables glial cell-derived neurotrophic factor receptor binding	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables growth factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables receptor tyrosine kinase binding	IEA Inferred from Electronic Annotation more info
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables transforming growth factor beta receptor binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in branching involved in ureteric bud morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to dexamethasone stimulus	ISO Inferred from Sequence Orthology more info
involved_in commissural neuron axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dorsal spinal cord development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in enteric nervous system development	IDA Inferred from Direct Assay more info	PubMed
involved_in enteric nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell-derived neurotrophic factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in glial cell-derived neurotrophic factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in mRNA stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in mesenchymal to epithelial transition involved in metanephros morphogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in mesenchymal to epithelial transition involved in metanephros morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within metanephros development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within metanephros development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metanephros development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural crest cell migration	ISO Inferred from Sequence Orthology more info
involved_in neural crest cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in neural crest cell migration involved in autonomic nervous system development	ISO Inferred from Sequence Orthology more info	PubMed
involved_in neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within organ induction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in peripheral nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within peripheral nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within peristalsis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peristalsis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of branching involved in ureteric bud morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of branching involved in ureteric bud morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of branching involved in ureteric bud morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of cell differentiation	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of monooxygenase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monooxygenase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ureteric bud formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ureteric bud formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in postganglionic parasympathetic fiber development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within postsynaptic membrane organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of dopamine uptake involved in synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in regulation of dopamine uptake involved in synaptic transmission	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within regulation of morphogenesis of a branching structure	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of semaphorin-plexin signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of ureteric bud formation	ISO Inferred from Sequence Orthology more info
involved_in sympathetic nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within ureteric bud development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within ureteric bud development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ureteric bud formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glial cell line-derived neurotrophic factor

Names: astrocyte-derived trophic factor; neurotrophic factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001301332.1 → NP_001288261.1 glial cell line-derived neurotrophic factor isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) has an alternate splice site in the 5' coding region but maintains the reading frame, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.

Source sequence(s)

AC130656, CJ061678, CJ093961, U75532

UniProtKB/Swiss-Prot

P48540

Conserved Domains (1) summary

pfam00019
Location:119 → 213

TGF_beta; Transforming growth factor beta like domain
NM_001301333.1 → NP_001288262.1 glial cell line-derived neurotrophic factor isoform 3 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC130656

Conserved Domains (1) summary

pfam00019
Location:136 → 230

TGF_beta; Transforming growth factor beta like domain
NM_001301357.1 → NP_001288286.1 glial cell line-derived neurotrophic factor isoform 4 preproprotein

See identical proteins and their annotated locations for NP_001288286.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (4) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC130656

UniProtKB/Swiss-Prot

O09058, P48540, P70446, P97919, P97920, Q6LEL9

Conserved Domains (1) summary

pfam00019
Location:116 → 210

TGF_beta; Transforming growth factor beta like domain
NM_010275.3 → NP_034405.1 glial cell line-derived neurotrophic factor isoform 1 precursor

See identical proteins and their annotated locations for NP_034405.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC130656, CJ061678, CJ093961, D88264

Consensus CDS

CCDS27371.1

UniProtKB/Swiss-Prot

P48540

Related

ENSMUSP00000022744.4, ENSMUST00000022744.5

Conserved Domains (1) summary

pfam00019
Location:145 → 239

TGF_beta; Transforming growth factor beta like domain