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Ggta1 glycoprotein galactosyltransferase alpha 1, 3 [ Mus musculus (house mouse) ]

Gene ID: 14594, updated on 2-Nov-2024

Summary

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Official Symbol
Ggta1provided by MGI
Official Full Name
glycoprotein galactosyltransferase alpha 1, 3provided by MGI
Primary source
MGI:MGI:95704
See related
Ensembl:ENSMUSG00000035778 AllianceGenome:MGI:95704
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gal; GALT; Ggta; Ggta-1; alpha Gal; alpha3GalT
Summary
This gene encodes a member of the galactosyltransferase family of intracellular, membrane-bound enzymes that are involved in the biosynthesis of glycoproteins and glycolipids. The encoded protein catalyzes the transfer of galactose from UDP-galactose to N-acetyllactosamine in an alpha(1,3) linkage to form galactose alpha(1,3)-galactose. Mice lacking the encoded protein develop cortical cataracts. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2015]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 6.2), lung adult (RPKM 5.8) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Ggta1 in Genome Data Viewer
Location:
2 B; 2 23.6 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (35290191..35354393, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (35400179..35464381, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930568D16 gene Neighboring gene RIKEN cDNA 4930402F06 gene Neighboring gene predicted gene, 39797 Neighboring gene STARR-positive B cell enhancer ABC_E9510 Neighboring gene STARR-positive B cell enhancer mm9_chr2:35316734-35317035 Neighboring gene STARR-positive B cell enhancer ABC_E2034 Neighboring gene transmembrane emp24 protein transport domain containing 9 pseudogene Neighboring gene predicted gene 13445

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. In vivo T-cell depletion enhances production of anti-GALalpha1,3GAL natural antibodies in alpha1,3-galactosyltransferase-deficient mice. Ohdan H, et al. Transplantation, 2000 Mar 15. PMID 10755549
  2. Cutting Edge: NK cells mediate IgG1-dependent hyperacute rejection of xenografts. Yin D, et al. J Immunol, 2004 Jun 15. PMID 15187097
  3. Suppression of Lewis lung tumor development in alpha 1,3 galactosyltransferase knock-out mice. Posekany KJ, et al. Anticancer Res, 2004 Mar-Apr. PMID 15161001
  4. Mouse-heart grafts expressing an incompatible carbohydrate antigen. II. Transition from accommodation to tolerance. Ogawa H, et al. Transplantation, 2004 Feb 15. PMID 14966409
  5. Tolerance induction to a mammalian blood group-like carbohydrate antigen by syngeneic lymphocytes expressing the antigen. Ogawa H, et al. Blood, 2003 Mar 15. PMID 12406874

See all (81) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Report immune responses and calcification in bovine/porcine heart valves implanted in alpha1,3-galactosyltransferase knockout mice.
    Title: The Immune Responses and Calcification of Bioprostheses in the α1,3-Galactosyltransferase Knockout Mouse.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetyllactosaminide 3-alpha-galactosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi cisterna ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi cisterna ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
N-acetyllactosaminide alpha-1,3-galactosyltransferase
Names
UDP-galactose:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminide alpha-1,3-galactosyltransferase
glycoprotein alpha galactosyl transferase 1
NP_001139293.1
NP_001295228.1
NP_001295229.1
NP_001407194.1
NP_001407195.1
NP_001407196.1
NP_001407197.1
NP_001407198.1
NP_001407199.1
NP_001407200.1
NP_001407201.1
NP_001407202.1
NP_001407206.1
NP_001407207.1
NP_034413.2
XP_011237329.1
XP_011237330.1
XP_011237331.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145821.3 → NP_001139293.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 2

    See identical proteins and their annotated locations for NP_001139293.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Variants 2 and 7 both encode the same isoform (2).
    Source sequence(s)
    AL929076, AL929199
    Consensus CDS
    CCDS50576.1
    UniProtKB/Swiss-Prot
    P23336, Q91V22
    UniProtKB/TrEMBL
    Q3TXW0
    Related
    ENSMUSP00000108626.3, ENSMUST00000113002.9
    Conserved Domains (1) summary
    pfam03414
    Location:71 → 392
    Glyco_transf_6; Glycosyltransferase family 6

  2. NM_001308299.2 → NP_001295228.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 3

    See identical proteins and their annotated locations for NP_001295228.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AL929076, AL929199
    Consensus CDS
    CCDS79787.1
    UniProtKB/TrEMBL
    A2AUR0, Q8C2H7
    Related
    ENSMUSP00000108625.3, ENSMUST00000113001.9
    Conserved Domains (1) summary
    pfam03414
    Location:81 → 382
    Glyco_transf_6; Glycosyltransferase family 6

  3. NM_001308300.2 → NP_001295229.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 4

    See identical proteins and their annotated locations for NP_001295229.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1. Variants 4 and 8 both encode the same isoform (4).
    Source sequence(s)
    AL929076, AL929199
    Consensus CDS
    CCDS79786.1
    UniProtKB/TrEMBL
    Q91W00
    Related
    ENSMUSP00000078393.5, ENSMUST00000079424.11
    Conserved Domains (1) summary
    pfam03414
    Location:69 → 370
    Glyco_transf_6; Glycosyltransferase family 6

  4. NM_001420265.1 → NP_001407194.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 5, and 6 all encode the same isoform (1).
    Source sequence(s)
    AL929076, AL929199
    UniProtKB/TrEMBL
    Q9DBU1

  5. NM_001420266.1 → NP_001407195.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1, 5, and 6 all encode the same isoform (1).
    Source sequence(s)
    AL929199
    UniProtKB/TrEMBL
    Q9DBU1
    Related
    ENSMUSP00000049408.7, ENSMUST00000044255.13

  6. NM_001420267.1 → NP_001407196.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 2. Variants 2 and 7 both encode the same isoform (2).
    Source sequence(s)
    AL929076, AL929199
    UniProtKB/Swiss-Prot
    P23336, Q91V22
    UniProtKB/TrEMBL
    Q3TXW0

  7. NM_001420268.1 → NP_001407197.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 4. Variants 4 and 8 both encode the same isoform (4).
    Source sequence(s)
    AL929076, AL929199
    UniProtKB/TrEMBL
    Q91W00

  8. NM_001420269.1 → NP_001407198.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL929076, AL929199

  9. NM_001420270.1 → NP_001407199.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL929076, AL929199

  10. NM_001420271.1 → NP_001407200.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL929076, AL929199

  11. NM_001420272.1 → NP_001407201.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL929076, AL929199

  12. NM_001420273.1 → NP_001407202.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL929076, AL929199

  13. NM_001420277.1 → NP_001407206.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL929076, AL929199

  14. NM_001420278.1 → NP_001407207.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL929076, AL929199

  15. NM_010283.5 → NP_034413.2  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 1

    See identical proteins and their annotated locations for NP_034413.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 5, and 6 all encode the same isoform (1).
    Source sequence(s)
    AL929076, AL929199
    Consensus CDS
    CCDS15964.2
    UniProtKB/TrEMBL
    Q9DBU1
    Related
    ENSMUSP00000099858.2, ENSMUST00000102794.8
    Conserved Domains (1) summary
    pfam03414
    Location:83 → 404
    Glyco_transf_6; Glycosyltransferase family 6

RNA

  1. NR_185155.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL929076, AL929199

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    35290191..35354393 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239029.2 → XP_011237331.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X1

    See identical proteins and their annotated locations for XP_011237331.1

    UniProtKB/TrEMBL
    Q9DBU1
    Conserved Domains (1) summary
    pfam03414
    Location:83 → 404
    Glyco_transf_6; Glycosyltransferase family 6

  2. XM_011239027.3 → XP_011237329.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X1

    See identical proteins and their annotated locations for XP_011237329.1

    UniProtKB/TrEMBL
    Q9DBU1
    Conserved Domains (1) summary
    pfam03414
    Location:83 → 404
    Glyco_transf_6; Glycosyltransferase family 6

  3. XM_011239028.4 → XP_011237330.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X1

    See identical proteins and their annotated locations for XP_011237330.1

    UniProtKB/TrEMBL
    Q9DBU1
    Conserved Domains (1) summary
    pfam03414
    Location:83 → 404
    Glyco_transf_6; Glycosyltransferase family 6
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23336.1 GenPept UniProtKB/Swiss-Prot:P23336

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