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LSO2 Lso2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 1466460, updated on 2-Nov-2024

Summary

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Official Symbol
LSO2
Official Full Name
Lso2p
Primary source
SGD:S000028521
Locus tag
YGR169C-A
See related
AllianceGenome:SGD:S000028521; FungiDB:YGR169C-A; VEuPathDB:YGR169C-A
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YGR169C-C
Summary
Enables ribosome binding activity. Involved in cellular response to nutrient; cytoplasmic translational elongation; and intracellular iron ion homeostasis. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See LSO2 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (836387..836665, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Pex35p Neighboring gene pseudouridine synthase PUS6 Neighboring gene phosphatidylserine decarboxylase 2 Neighboring gene methionine--tRNA ligase MSM1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Lso2 is a conserved ribosome-bound protein required for translational recovery in yeast. Wang YJ, et al. PLoS Biol, 2018 Sep. PMID 30208026, Free PMC Article
  2. Structure and function of yeast Lso2 and human CCDC124 bound to hibernating ribosomes. Wells JN, et al. PLoS Biol, 2020 Jul. PMID 32687489, Free PMC Article
  3. The late-annotated small ORF LSO1 is a target gene of the iron regulon of Saccharomyces cerevisiae. An X, et al. Microbiologyopen, 2015 Dec. PMID 26450372, Free PMC Article
  4. A chemical potentiator of copper-accumulation used to investigate the iron-regulons of Saccharomyces cerevisiae. Foster AW, et al. Mol Microbiol, 2014 Jul. PMID 24895027, Free PMC Article
  5. Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii. Brachat S, et al. Genome Biol, 2003. PMID 12844361, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ribosome binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to nutrient IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytoplasmic translational elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Lso2p
NP_878080.3
  • Ribosome-associated protein; required for global translational elongation after recovery from stationary phase due to starvation; crosslinks to the 25S rRNA near the A site that overlaps the GTPase activation center, and to tRNAs; possible role in the iron deprivation response; localizes to the nucleus and cytoplasm, with enhanced nuclear localization under iron-replete conditions; null mutant exhibits slow growth during iron deprivation; orthologous to human CCDC124

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    836387..836665 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184531.3 → NP_878080.3  TPA: Lso2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_878080.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUV3, Q3E772
    UniProtKB/TrEMBL
    A6ZUI0, B3LI61, C7GQ76, C8Z965, N1P603
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3E772.1

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