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COA2 Coa2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 1466518, updated on 2-Nov-2024

Summary

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Official Symbol
COA2
Official Full Name
Coa2p
Primary source
SGD:S000028527
Locus tag
YPL189C-A
See related
AllianceGenome:SGD:S000028527; FungiDB:YPL189C-A; VEuPathDB:YPL189C-A
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in mitochondrial cytochrome c oxidase assembly. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See COA2 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (188307..188513, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene ubiquitinyl hydrolase 1 Neighboring gene Nab3p Neighboring gene putative O-acyltransferase Neighboring gene NADH kinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CcO assembly factor Coa2 appears important in coupling the presence of newly synthesized Cox1 to Cox10 oligomerization
    Title: Oligomerization of heme o synthase in cytochrome oxidase biogenesis is mediated by cytochrome oxidase assembly factor Coa2.
  2. Coa2 appears to impart stability to the oligomeric wild-type Cox10 complex involved in Cox1 hemylation.
    Title: The role of Coa2 in hemylation of yeast Cox1 revealed by its genetic interaction with Cox10.
  3. The matrix-localized Coa2 protein may aid in stabilizing an early Cox1 intermediate containing the nuclear subunits Cox5a and Cox6.
    Title: Coa2 is an assembly factor for yeast cytochrome c oxidase biogenesis that facilitates the maturation of Cox1.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in mitochondrial cytochrome c oxidase assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial cytochrome c oxidase assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial cytochrome c oxidase assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial cytochrome c oxidase assembly IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Coa2p
NP_878179.1
  • Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    188307..188513 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184537.1 → NP_878179.1  TPA: Coa2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_878179.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3H9, Q3E823
    UniProtKB/TrEMBL
    A6ZW64, B3LKN9, C7GJD8, C8ZII9, G2WNZ4, N1NVN7
    Conserved Domains (1) summary
    pfam17051
    Location:1 → 67
    COA2; Cytochrome C oxidase assembly factor 2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3E823.1

Gene LinkOut

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