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Gna15 guanine nucleotide binding protein, alpha 15 [ Mus musculus (house mouse) ]

Gene ID: 14676, updated on 2-Nov-2024

Summary

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Official Symbol
Gna15provided by MGI
Official Full Name
guanine nucleotide binding protein, alpha 15provided by MGI
Primary source
MGI:MGI:95770
See related
Ensembl:ENSMUSG00000034792 AllianceGenome:MGI:95770
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hg1l; G[a]15; Galpha15
Summary
Enables G protein-coupled receptor binding activity. Acts upstream of or within with a positive effect on calcium-mediated signaling. Acts upstream of or within phospholipase C-activating G protein-coupled receptor signaling pathway. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm. Is expressed in brain and retina. Orthologous to human GNA15 (G protein subunit alpha 15). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in spleen adult (RPKM 5.4), bladder adult (RPKM 4.6) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Gna15 in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (81338147..81360283, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81502313..81524447, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_27338 Neighboring gene nicalin Neighboring gene STARR-positive B cell enhancer ABC_E8350 Neighboring gene sphingosine-1-phosphate receptor 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:80973115-80973298 Neighboring gene STARR-positive B cell enhancer ABC_E11449 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:80989510-80989711 Neighboring gene guanine nucleotide binding protein, alpha 11 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:81014523-81014724 Neighboring gene TLE family member 5, transcriptional modulator

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Functional Role of the C-Terminal Amphipathic Helix 8 of Olfactory Receptors and Other G Protein-Coupled Receptors. Sato T, et al. Int J Mol Sci, 2016 Nov 18. PMID 27869740, Free PMC Article
  2. Characterization of G-protein alpha subunits in the Gq class: expression in murine tissues and in stromal and hematopoietic cell lines. Wilkie TM, et al. Proc Natl Acad Sci U S A, 1991 Nov 15. PMID 1946421, Free PMC Article
  3. The N-terminal acidic residue of the cytosolic helix 8 of an odorant receptor is responsible for different response dynamics via G-protein. Kawasaki T, et al. FEBS Lett, 2015 Apr 28. PMID 25839907
  4. Gene structure of murine Gna11 and Gna15: tandemly duplicated Gq class G protein alpha subunit genes. Davignon I, et al. Genomics, 1996 Feb 1. PMID 8838318
  5. Promiscuous coupling of receptors to Gq class alpha subunits and effector proteins in pancreatic and submandibular gland cells. Xu X, et al. J Biol Chem, 1998 Oct 16. PMID 9765251

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that the hydrophobic core buried between helix 8 and TM1-2 of olfactory receptor (mOR-S6) is important for the activation of both G protein alpha 15 (Galpha15).
    Title: Functional Role of the C-Terminal Amphipathic Helix 8 of Olfactory Receptors and Other G Protein-Coupled Receptors.
  2. The N-terminal hydrophobic core between helix 8 and TM1-2 of mOR-S6 is important for activation of both Galpha15_olf and Galpha15.
    Title: The N-terminal acidic residue of the cytosolic helix 8 of an odorant receptor is responsible for different response dynamics via G-protein.
  3. Gna15 maps to mouse chromosome 10 and has similar tissue distribution to mouse s1p(4); transcription of the two genes may be under control of the same enhancer elements
    Title: Tandem genomic arrangement of a G protein (Gna15) and G protein-coupled receptor (s1p(4)/lp(C1)/Edg6) gene.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables G-protein beta/gamma-subunit complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G-protein beta/gamma-subunit complex binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity TAS
Traceable Author Statement
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within_positive_effect calcium-mediated signaling IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within_positive_effect calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipase C-activating dopamine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of heterotrimeric G-protein complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
guanine nucleotide-binding protein subunit alpha-15
Names
G-protein subunit alpha-15
g alpha-15
heterotrimeric guanine nucleotide-binding protein 1l

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010304.3 → NP_034434.1  guanine nucleotide-binding protein subunit alpha-15

    See identical proteins and their annotated locations for NP_034434.1

    Status: PROVISIONAL

    Source sequence(s)
    BC005439
    Consensus CDS
    CCDS24060.1
    UniProtKB/Swiss-Prot
    P30678, Q8K1S0
    Related
    ENSMUSP00000049175.8, ENSMUST00000043709.8
    Conserved Domains (1) summary
    cd00066
    Location:49 → 368
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    81338147..81360283 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513234.5 → XP_006513297.1  guanine nucleotide-binding protein subunit alpha-15 isoform X2

    Conserved Domains (1) summary
    cd00066
    Location:49 → 392
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

  2. XM_006513233.5 → XP_006513296.1  guanine nucleotide-binding protein subunit alpha-15 isoform X1

    Conserved Domains (1) summary
    cd00066
    Location:49 → 393
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30678.1 GenPept UniProtKB/Swiss-Prot:P30678

Gene LinkOut

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