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Grb10 growth factor receptor bound protein 10 [ Mus musculus (house mouse) ]

Gene ID: 14783, updated on 2-Nov-2024

Summary

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Official Symbol
Grb10provided by MGI
Official Full Name
growth factor receptor bound protein 10provided by MGI
Primary source
MGI:MGI:103232
See related
Ensembl:ENSMUSG00000020176 AllianceGenome:MGI:103232
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Meg1; mKIAA0207; 5730571D09Rik
Summary
Enables insulin receptor binding activity and signaling receptor complex adaptor activity. Involved in several processes, including negative regulation of D-glucose import; negative regulation of signal transduction; and positive regulation of cold-induced thermogenesis. Acts upstream of or within with a negative effect on ERK1 and ERK2 cascade and gene expression. Acts upstream of or within insulin-like growth factor receptor signaling pathway and vascular associated smooth muscle cell migration. Predicted to be located in cytosol. Predicted to be part of protein-containing complex. Is expressed in several structures, including central nervous system; extraembryonic component; genitourinary system; musculoskeletal system; and sensory organ. Orthologous to human GRB10 (growth factor receptor bound protein 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in limb E14.5 (RPKM 223.2), liver E18 (RPKM 212.5) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Grb10 in Genome Data Viewer
Location:
11 A1; 11 7.15 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (11880499..11987428, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (11930499..12037428, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene dopa decarboxylase Neighboring gene RIKEN cDNA 1700042O10 gene Neighboring gene STARR-seq mESC enhancer starr_28608 Neighboring gene STARR-seq mESC enhancer starr_28612 Neighboring gene predicted gene, 25058 Neighboring gene VISTA enhancer mm154 Neighboring gene uncharacterized LOC102631979 Neighboring gene VISTA enhancer mm178 Neighboring gene predicted gene, 30423 Neighboring gene predicted gene, 24036

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Effect of vitrification on in vitro development and imprinted gene Grb10 in mouse embryos. Yao J, et al. Reproduction, 2017 Sep. PMID 28696244
  2. Epigenetic modifications and mRNA levels of the imprinted gene Grb10 in serially passaged fibroblast cells. Yao J, et al. Biochimie, 2012 Dec. PMID 22971350
  3. Conserved methylation imprints in the human and mouse GRB10 genes with divergent allelic expression suggests differential reading of the same mark. Arnaud P, et al. Hum Mol Genet, 2003 May 1. PMID 12700169
  4. Disruption of growth factor receptor-binding protein 10 in the pancreas enhances β-cell proliferation and protects mice from streptozotocin-induced β-cell apoptosis. Zhang J, et al. Diabetes, 2012 Dec. PMID 22923474, Free PMC Article
  5. Grb10 regulates the development of fiber number in skeletal muscle. Holt LJ, et al. FASEB J, 2012 Sep. PMID 22623587

See all (122) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hypothalamic Grb10 enhances leptin signalling and promotes weight loss.
    Title: Hypothalamic Grb10 enhances leptin signalling and promotes weight loss.
  2. GRB10 regulates beta-cell mass by inhibiting beta-cell proliferation and stimulating beta-cell dedifferentiation.
    Title: GRB10 regulates β-cell mass by inhibiting β-cell proliferation and stimulating β-cell dedifferentiation.
  3. Mice lacking paternal expression of imprinted Grb10 are risk-takers.
    Title: Mice lacking paternal expression of imprinted Grb10 are risk-takers.
  4. Detailed analysis of paternal knockout Grb10 mice suggests effects on stability of social behavior, rather than social dominance.
    Title: Detailed analysis of paternal knockout Grb10 mice suggests effects on stability of social behavior, rather than social dominance.
  5. Grb10 gene could be reactivated in adult mouse liver by acute endoplasmic reticulum stress.
    Title: De-silencing Grb10 contributes to acute ER stress-induced steatosis in mouse liver.
  6. ablation of growth factor receptor bound protein 10 (Grb10) in muscle is sufficient to affect muscle size and metabolism, supporting an important role for this protein in growth and metabolic pathways
    Title: Ablation of Grb10 Specifically in Muscle Impacts Muscle Size and Glucose Metabolism in Mice.
  7. DNA methylation at CpG island 1 (CGI1) of Grb10 in blastocysts were also significantly decreased after vitrification
    Title: Effect of vitrification on in vitro development and imprinted gene Grb10 in mouse embryos.
  8. This study reveals a function for the imprinted gene Grb10 in regulating hematopoietic stem cell self-renewal.
    Title: Deletion of the Imprinted Gene Grb10 Promotes Hematopoietic Stem Cell Self-Renewal and Regeneration.
  9. In tumors, Grb10 loss independently promotes Ras pathway hyperactivation, which promotes hyperproliferation, an early feature of tumor development.
    Title: Monoallelic loss of the imprinted gene Grb10 promotes tumor formation in irradiated Nf1+/- mice.
  10. This study identified Grb10 as a critical regulator of lipid metabolism, the programming of the browning phenotype, and thermogenesis in adipose tissues.
    Title: Grb10 promotes lipolysis and thermogenesis by phosphorylation-dependent feedback inhibition of mTORC1.
Submit: New GeneRIF Correction See all GeneRIFs (41)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables insulin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables insulin receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables insulin receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphotyrosine residue binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables signaling receptor complex adaptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within_negative_effect ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within_negative_effect gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within insulin-like growth factor receptor signaling pathway IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in negative regulation of D-glucose import IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of Wnt signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of glycogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of glycogen biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to insulin ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within signal transduction TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within vascular associated smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 PubMed 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
growth factor receptor-bound protein 10
Names
GRB10 adapter protein
maternally expressed gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177629.1 → NP_001171100.1  growth factor receptor-bound protein 10 isoform 2

    See identical proteins and their annotated locations for NP_001171100.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' non-coding exon, and is missing in-frame coding exons compared to variant 3. This results in a shorter isoform (2) lacking an internal protein segment compared to isoform 3.
    Source sequence(s)
    AL663087, BC053842, BY122902, CK635114
    Consensus CDS
    CCDS48754.1
    UniProtKB/TrEMBL
    Q5SUW3
    Related
    ENSMUSP00000105281.2, ENSMUST00000109654.8
    Conserved Domains (4) summary
    cd10415
    Location:434 → 541
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:234 → 356
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16141
    Location:114 → 205
    RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
    pfam08947
    Location:373 → 414
    BPS; BPS (Between PH and SH2)

  2. NM_001370603.1 → NP_001357532.1  growth factor receptor-bound protein 10 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes isoform (3).
    Source sequence(s)
    AL645803, AL663087
    UniProtKB/Swiss-Prot
    O35352, Q3TQ71, Q60760, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5
    UniProtKB/TrEMBL
    Q5SUW3
    Conserved Domains (4) summary
    cd10415
    Location:514 → 621
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:314 → 436
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:453 → 494
    BPS; BPS (Between PH and SH2)
    cd16141
    Location:197 → 285
    RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10

  3. NM_010345.4 → NP_034475.2  growth factor receptor-bound protein 10 isoform 1

    See identical proteins and their annotated locations for NP_034475.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) includes an alternate internal exon, compared to variant 3. It encodes isoform 1 which is shorter, compared to isoform 3.
    Source sequence(s)
    BC053842, CK635114, FJ425892
    Consensus CDS
    CCDS24440.1
    UniProtKB/TrEMBL
    Q5SUW3
    Related
    ENSMUSP00000091011.6, ENSMUST00000093321.12
    Conserved Domains (5) summary
    cd01787
    Location:170 → 251
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:489 → 596
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:289 → 411
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam00169
    Location:294 → 402
    PH; PH domain
    pfam08947
    Location:428 → 469
    BPS; BPS (Between PH and SH2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    11880499..11987428 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243664.2 → XP_011241966.1  growth factor receptor-bound protein 10 isoform X1

    See identical proteins and their annotated locations for XP_011241966.1

    UniProtKB/TrEMBL
    Q5SUW3
    Conserved Domains (4) summary
    cd10415
    Location:434 → 541
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:234 → 356
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16141
    Location:114 → 205
    RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
    pfam08947
    Location:373 → 414
    BPS; BPS (Between PH and SH2)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60760.2 GenPept UniProtKB/Swiss-Prot:Q60760

Gene LinkOut

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