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ZNF569 zinc finger protein 569 [ Homo sapiens (human) ]

Gene ID: 148266, updated on 17-Aug-2024

Summary

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Official Symbol
ZNF569provided by HGNC
Official Full Name
zinc finger protein 569provided by HGNC
Primary source
HGNC:HGNC:24737
See related
Ensembl:ENSG00000196437 MIM:613904; AllianceGenome:HGNC:24737
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF; ZAP1; Zfp74
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 4.0), thyroid (RPKM 2.7) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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See ZNF569 in Genome Data Viewer
Location:
19q13.12
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (37411157..37469265, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (40212656..40270764, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (37902059..37958346, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10554 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14541 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:37809147-37810044 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:37811117-37811765 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:37811766-37812414 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37824558-37825500 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37825501-37826442 Neighboring gene zinc finger protein 875 Neighboring gene MPRA-validated peak3463 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14545 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14546 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10555 Neighboring gene zinc finger protein 527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14547 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14548 Neighboring gene zinc finger protein 570 Neighboring gene ZNF793 antisense RNA 1 (head to head) Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37996759-37997550 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37997551-37998342 Neighboring gene zinc finger protein 793 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:38020876-38021698 Neighboring gene uncharacterized LOC124904708 Neighboring gene ZNF571 antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ZNF569, a novel KRAB-containing zinc finger protein, suppresses MAPK signaling pathway. Huang X, et al. Biochem Biophys Res Commun, 2006 Aug 4. PMID 16793018
  2. Characterization and mapping of human genes encoding zinc finger proteins. Bray P, et al. Proc Natl Acad Sci U S A, 1991 Nov 1. PMID 1946370, Free PMC Article
  3. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. Lichter P, et al. Genomics, 1992 Aug. PMID 1505991
  4. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. Nozawa RS, et al. Nat Cell Biol, 2010 Jul. PMID 20562864
  5. PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion. Dart AE, et al. J Cell Biol, 2015 Nov 23. PMID 26598620, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF569 protein may act as a transcriptional repressor that suppresses MAPK signaling pathway to mediate cellular functions
    Title: ZNF569, a novel KRAB-containing zinc finger protein, suppresses MAPK signaling pathway.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ32053

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 569
Names
DNA-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330482.2 → NP_001317411.1  zinc finger protein 569 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008806
    Consensus CDS
    CCDS82341.1
    UniProtKB/Swiss-Prot
    Q5MCW4
    Conserved Domains (2) summary
    COG5048
    Location:109 → 521
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:85 → 105
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_152484.3 → NP_689697.2  zinc finger protein 569 isoform 1

    See identical proteins and their annotated locations for NP_689697.2

    Status: VALIDATED

    Source sequence(s)
    AC008806, AK122846, AL833408, BC038737, CB151734
    Consensus CDS
    CCDS12503.1
    UniProtKB/Swiss-Prot
    A8K1S2, Q15925, Q17RR6, Q5MCW4, Q96MQ2
    Related
    ENSP00000325018.5, ENST00000316950.11
    Conserved Domains (3) summary
    smart00349
    Location:8 → 62
    KRAB; krueppel associated box
    COG5048
    Location:268 → 680
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:244 → 264
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    37411157..37469265 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723048.5 → XP_006723111.1  zinc finger protein 569 isoform X1

    See identical proteins and their annotated locations for XP_006723111.1

    UniProtKB/TrEMBL
    K7ELU1
    Conserved Domains (3) summary
    smart00349
    Location:32 → 86
    KRAB; krueppel associated box
    COG5048
    Location:292 → 704
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:268 → 288
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_011526538.4 → XP_011524840.1  zinc finger protein 569 isoform X1

    See identical proteins and their annotated locations for XP_011524840.1

    UniProtKB/TrEMBL
    K7ELU1
    Conserved Domains (3) summary
    smart00349
    Location:32 → 86
    KRAB; krueppel associated box
    COG5048
    Location:292 → 704
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:268 → 288
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_047438278.1 → XP_047294234.1  zinc finger protein 569 isoform X1

    UniProtKB/TrEMBL
    K7ELU1

  4. XM_017026379.2 → XP_016881868.1  zinc finger protein 569 isoform X3

    UniProtKB/Swiss-Prot
    Q5MCW4
    Related
    ENSP00000375993.2, ENST00000392150.2
    Conserved Domains (2) summary
    COG5048
    Location:109 → 521
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:85 → 105
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_006723047.5 → XP_006723110.1  zinc finger protein 569 isoform X1

    See identical proteins and their annotated locations for XP_006723110.1

    UniProtKB/TrEMBL
    K7ELU1
    Conserved Domains (3) summary
    smart00349
    Location:32 → 86
    KRAB; krueppel associated box
    COG5048
    Location:292 → 704
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:268 → 288
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. XM_006723046.3 → XP_006723109.1  zinc finger protein 569 isoform X1

    See identical proteins and their annotated locations for XP_006723109.1

    UniProtKB/TrEMBL
    K7ELU1
    Related
    ENSP00000466221.2, ENST00000448051.7
    Conserved Domains (3) summary
    smart00349
    Location:32 → 86
    KRAB; krueppel associated box
    COG5048
    Location:292 → 704
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:268 → 288
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. XM_047438277.1 → XP_047294233.1  zinc finger protein 569 isoform X1

    UniProtKB/TrEMBL
    K7ELU1

  8. XM_011526539.4 → XP_011524841.1  zinc finger protein 569 isoform X2

    See identical proteins and their annotated locations for XP_011524841.1

    UniProtKB/Swiss-Prot
    A8K1S2, Q15925, Q17RR6, Q5MCW4, Q96MQ2
    Related
    ENSP00000375992.2, ENST00000392149.6
    Conserved Domains (3) summary
    smart00349
    Location:8 → 62
    KRAB; krueppel associated box
    COG5048
    Location:268 → 680
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:244 → 264
    ZF_C2H2; C2H2 Zn finger [structural motif]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    40212656..40270764 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320011.1 → XP_054175986.1  zinc finger protein 569 isoform X1

    UniProtKB/TrEMBL
    K7ELU1

  2. XM_054320013.1 → XP_054175988.1  zinc finger protein 569 isoform X3

  3. XM_054320008.1 → XP_054175983.1  zinc finger protein 569 isoform X1

    UniProtKB/TrEMBL
    K7ELU1

  4. XM_054320009.1 → XP_054175984.1  zinc finger protein 569 isoform X1

    UniProtKB/TrEMBL
    K7ELU1

  5. XM_054320010.1 → XP_054175985.1  zinc finger protein 569 isoform X1

    UniProtKB/TrEMBL
    K7ELU1

  6. XM_054320012.1 → XP_054175987.1  zinc finger protein 569 isoform X2

    UniProtKB/Swiss-Prot
    A8K1S2, Q15925, Q17RR6, Q5MCW4, Q96MQ2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5MCW4.1 GenPept UniProtKB/Swiss-Prot:Q5MCW4

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