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Gspt1 G1 to S phase transition 1 [ Mus musculus (house mouse) ]

Gene ID: 14852, updated on 14-Nov-2024

Summary

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Official Symbol
Gspt1provided by MGI
Official Full Name
G1 to S phase transition 1provided by MGI
Primary source
MGI:MGI:1316728
See related
Ensembl:ENSMUSG00000062203 AllianceGenome:MGI:1316728
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G1st; Gst-1
Summary
Predicted to enable GTPase activity and translation release factor activity. Predicted to be involved in regulation of translational termination and translational termination. Predicted to act upstream of or within protein methylation. Predicted to be part of translation release factor complex. Predicted to be active in cytosolic ribosome. Orthologous to human GSPT1 (G1 to S phase transition 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 23.1), CNS E11.5 (RPKM 15.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Gspt1 in Genome Data Viewer
Location:
16 A1; 16 6.38 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (11034104..11072189, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (11216240..11254325, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930509G22 gene Neighboring gene RIKEN cDNA 2610020C07 gene Neighboring gene Wdr45 like pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7427 Neighboring gene ribosomal L1 domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E8617 Neighboring gene predicted gene, 57631 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:11254345-11254532 Neighboring gene microRNA 1945 Neighboring gene STARR-seq mESC enhancer starr_40101 Neighboring gene tumor necrosis factor receptor superfamily, member 17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Potential of GSPT1 as a novel target for glioblastoma therapy. Sasayama T, et al. Cell Death Dis, 2024 Aug 8. PMID 39117611, Free PMC Article
  2. A human homologue of the yeast GST1 gene codes for a GTP-binding protein and is expressed in a proliferation-dependent manner in mammalian cells. Hoshino S, et al. EMBO J, 1989 Dec 1. PMID 2511002, Free PMC Article
  3. A Novel Rac1-GSPT1 Signaling Pathway Controls Astrogliosis Following Central Nervous System Injury. Ishii T, et al. J Biol Chem, 2017 Jan 27. PMID 27941025, Free PMC Article
  4. In vitro reconstitution of eukaryotic translation reveals cooperativity between release factors eRF1 and eRF3. Alkalaeva EZ, et al. Cell, 2006 Jun 16. PMID 16777602
  5. Molecular cloning of a novel member of the eukaryotic polypeptide chain-releasing factors (eRF). Its identification as eRF3 interacting with eRF1. Hoshino S, et al. J Biol Chem, 1998 Aug 28. PMID 9712840

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC36230, MGC36735

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables translation release factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation release factor activity ISO
Inferred from Sequence Orthology
more info
  
enables translation release factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein methylation ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in regulation of translational termination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of translational termination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational termination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosolic ribosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
part_of translation release factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of translation release factor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
eukaryotic peptide chain release factor GTP-binding subunit ERF3A
Names
G1 to S phase transition protein 1 homolog
G1 to phase transition 1
G1-to-S transition GTP binding protein
eRF3a
eukaryotic peptide chain release factor subunit 3a
eukaryotic polypeptide chain release factor 3
guanine nucleotide regulatory protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130008.1 → NP_001123480.1  eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform 2

    See identical proteins and their annotated locations for NP_001123480.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in an internal exon, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.
    Source sequence(s)
    AC087541, AK032059, AK148603, BB631229, CJ260597
    Consensus CDS
    CCDS49764.1
    UniProtKB/Swiss-Prot
    Q8R050
    UniProtKB/TrEMBL
    Q8CCV1
    Related
    ENSMUSP00000130583.2, ENSMUST00000167571.8
    Conserved Domains (5) summary
    cd01883
    Location:212 → 428
    EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family
    COG5256
    Location:208 → 632
    TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
    pfam07145
    Location:64 → 81
    PAM2; Ataxin-2 C-terminal region
    cd04089
    Location:437 → 518
    eRF3_II; Domain II of the eukaryotic class II release factor
    cd03704
    Location:524 → 630
    eRF3_C_III; C-terminal domain of eRF3

  2. NM_146066.2 → NP_666178.2  eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform 1

    See identical proteins and their annotated locations for NP_666178.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC087541, AK148603, BB631229, CJ260597
    Consensus CDS
    CCDS27961.2
    UniProtKB/Swiss-Prot
    E9QK49, G3UWC0, O88179, Q8K2E1, Q8R050
    Related
    ENSMUSP00000078940.8, ENSMUST00000080030.14
    Conserved Domains (5) summary
    cd01883
    Location:213 → 429
    EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family
    COG5256
    Location:209 → 633
    TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
    pfam07145
    Location:64 → 81
    PAM2; Ataxin-2 C-terminal region
    cd04089
    Location:438 → 519
    eRF3_II; Domain II of the eukaryotic class II release factor
    cd03704
    Location:525 → 631
    eRF3_C_III; C-terminal domain of eRF3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    11034104..11072189 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R050.2 GenPept UniProtKB/Swiss-Prot:Q8R050

Gene LinkOut

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