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Gss glutathione synthetase [ Mus musculus (house mouse) ]

Gene ID: 14854, updated on 5-Nov-2024

Summary

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Official Symbol
Gssprovided by MGI
Official Full Name
glutathione synthetaseprovided by MGI
Primary source
MGI:MGI:95852
See related
Ensembl:ENSMUSG00000027610 AllianceGenome:MGI:95852
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GSH-S; GS-A/GS-B
Summary
Enables glutathione synthase activity. Acts upstream of or within response to cadmium ion. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; integumental system; metanephros; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease; glutathione synthetase deficiency; glutathione synthetase deficiency of erythrocytes; and glutatione synthetase deficiency with 5-oxoprolinuria. Orthologous to human GSS (glutathione synthetase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in kidney adult (RPKM 72.6), colon adult (RPKM 41.7) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Gss in Genome Data Viewer
Location:
2 H1; 2 77.26 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (155405101..155434730, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (155563181..155592810, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene gamma-glutamyltransferase 7 Neighboring gene STARR-positive B cell enhancer ABC_E1258 Neighboring gene acyl-CoA synthetase short-chain family member 2 Neighboring gene STARR-positive B cell enhancer ABC_E7875 Neighboring gene acyl-CoA synthetase short-chain family member 2, opposite strand Neighboring gene glutathione synthase, opposite strand 2 Neighboring gene STARR-seq mESC enhancer starr_06145 Neighboring gene STARR-positive B cell enhancer ABC_E6005 Neighboring gene myosin, heavy chain 7B, cardiac muscle, beta Neighboring gene microRNA 499 Neighboring gene transient receptor potential cation channel, subfamily C, member 4 associated protein Neighboring gene predicted gene, 22334

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Gss deficiency causes age-related fertility impairment via ROS-triggered ferroptosis in the testes of mice. Zhu H, et al. Cell Death Dis, 2023 Dec 19. PMID 38114454, Free PMC Article
  2. DDI2 protease controls embryonic development and inflammation via TCF11/NRF1. Nedomova M, et al. iScience, 2024 Oct 18. PMID 39328932, Free PMC Article
  3. Induction of glutathione synthetase by 1,10-phenanthroline. Sun Y. FEBS Lett, 1997 May 12. PMID 9180259
  4. Developmental patterns of zygotes from transgenic female mice with elevated tissue glutathione. Rzucidlo SJ, et al. J Exp Zool, 2000 Feb 1. PMID 10617859
  5. Glutathione is essential for early embryogenesis--analysis of a glutathione synthetase knockout mouse. Winkler A, et al. Biochem Biophys Res Commun, 2011 Aug 19. PMID 21802407

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gss deficiency causes age-related fertility impairment via ROS-triggered ferroptosis in the testes of mice.
    Title: Gss deficiency causes age-related fertility impairment via ROS-triggered ferroptosis in the testes of mice.
  2. Cystine/Glutamate Xc[-] Antiporter Induction Compensates for Transsulfuration Pathway Repression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) to Ensure Cysteine for Hepatic Glutathione Biosynthesis.
    Title: Cystine/Glutamate Xc(-) Antiporter Induction Compensates for Transsulfuration Pathway Repression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) to Ensure Cysteine for Hepatic Glutathione Biosynthesis.
  3. the cause of cellular ATP depletion in nephrotic cystinosis may be the futile cycle, formed between two ATP-dependant gamma-glutamyl cycle enzymes, gamma-glutamyl cysteine synthetase and 5-oxoprolinase
    Title: A futile cycle, formed between two ATP-dependant gamma-glutamyl cycle enzymes, gamma-glutamyl cysteine synthetase and 5-oxoprolinase: the cause of cellular ATP depletion in nephrotic cystinosis?
  4. Hypoxia decreased 2 key enzyme activities that regulate GSH synthesis, glutamate cysteine ligase (GCL) (E.C. 6.3.2.2) and glutathione synthase (GS) (E.C. 6.3.2.3)
    Title: Hypoxia and kinase activity regulate lung epithelial cell glutathione.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glutathione binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione binding ISO
Inferred from Sequence Orthology
more info
  
enables glutathione binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glutathione synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutathione synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycine binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables peptide binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in glutathione biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glutathione biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to cadmium ion IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
glutathione synthetase
Names
GSH synthetase
glutathione synthase
NP_001278040.1
NP_032206.1
XP_006498844.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291111.1 → NP_001278040.1  glutathione synthetase isoform b

    See identical proteins and their annotated locations for NP_001278040.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' region, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AI846976, AK149577, AL844852
    Consensus CDS
    CCDS71167.1
    UniProtKB/TrEMBL
    Q3UEE2, Q8R436
    Related
    ENSMUSP00000135319.2, ENSMUST00000130881.8
    Conserved Domains (1) summary
    cl00170
    Location:1 → 405
    eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.

  2. NM_008180.2 → NP_032206.1  glutathione synthetase isoform a

    See identical proteins and their annotated locations for NP_032206.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AI846976, AK169096, AL844852
    Consensus CDS
    CCDS16951.1
    UniProtKB/Swiss-Prot
    P51855
    UniProtKB/TrEMBL
    Q3TWM2, Q541E2
    Related
    ENSMUSP00000078630.7, ENSMUST00000079691.13
    Conserved Domains (1) summary
    cd00228
    Location:6 → 474
    eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    155405101..155434730 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498781.4 → XP_006498844.1  glutathione synthetase isoform X1

    See identical proteins and their annotated locations for XP_006498844.1

    UniProtKB/Swiss-Prot
    P51855
    UniProtKB/TrEMBL
    Q3TWM2, Q541E2
    Conserved Domains (1) summary
    cd00228
    Location:6 → 474
    eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51855.1 GenPept UniProtKB/Swiss-Prot:P51855

Gene LinkOut

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