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E1 E1 [ human papillomavirus 18 ]

Gene ID: 1489084, updated on 18-Aug-2023

Summary

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Gene symbol
E1
Gene description
E1
Locus tag
HpV18gp3
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
human papillomavirus 18
Lineage
Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Alphapapillomavirus
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Genomic context

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Sequence:
NC_001357.1 (914..2887)

NC_001357.1Genomic Context describing neighboring genes Neighboring gene E6 protein Neighboring gene E7 protein Neighboring gene E2 protein Neighboring gene E4 protein Neighboring gene E5 protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001357.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Uncovering the Role of the E1 Protein in Different Stages of Human Papillomavirus 18 Genome Replication. Piirsoo A, et al. J Virol, 2020 Sep 29. PMID 32759324, Free PMC Article
  2. Intratypic changes of the E1 gene and the long control region affect ori function of human papillomavirus type 18 variants. Amador-Molina A, et al. J Gen Virol, 2013 Feb. PMID 23100366
  3. The full-length E1E4 protein of human papillomavirus type 18 modulates differentiation-dependent viral DNA amplification and late gene expression. Wilson R, et al. Virology, 2007 Jun 5. PMID 17303206
  4. Interferon-inducible protein, P56, inhibits HPV DNA replication by binding to the viral protein E1. Terenzi F, et al. EMBO J, 2008 Dec 17. PMID 19008854, Free PMC Article
  5. Nucleotide sequence and comparative analysis of the human papillomavirus type 18 genome. Phylogeny of papillomaviruses and repeated structure of the E6 and E7 gene products. Cole ST, et al. J Mol Biol, 1987 Feb 20. PMID 3039146

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Uncovering the Role of the E1 Protein in Different Stages of Human Papillomavirus 18 Genome Replication.
    Title: Uncovering the Role of the E1 Protein in Different Stages of Human Papillomavirus 18 Genome Replication.
  2. The authors found that variations in E1 and the long control region in fact affect ori function.
    Title: Intratypic changes of the E1 gene and the long control region affect ori function of human papillomavirus type 18 variants.
  3. Protein-protein interaction and mutational analyses established that the antiviral effect of ISG56 was mediated by its direct interaction with the DNA replication origin-binding protein E1
    Title: Interferon-inducible protein, P56, inhibits HPV DNA replication by binding to the viral protein E1.
  4. This indicates that HPV18 E1E4 plays an important role in regulating HPV late functions, and it may also function in the early phase of the replication cycle.
    Title: The full-length E1E4 protein of human papillomavirus type 18 modulates differentiation-dependent viral DNA amplification and late gene expression.
Submit: New GeneRIF Correction

General protein information

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Preferred Names
E1
NP_040312.1
  • E1; The Papillomaviriuses are icosahedral dsDNA viruses that encode 7 early proteins, E1 to E7, and 2 late structural proteins L1 and L2. Host infection by members of the papillomaviruses gives rise to warts and cancer in some instances. The E1 helicase protein is an ATP-dependent DNA helicase that facilitates the inititiation of viral DNA replication through its interactions with the viral E2 protein. The E1-E2 complex binds to the viral origin of replication where E1 acts to unwind the DNA and E2 acts as a transcriptional activator.

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001357.1 Reference assembly

    Range
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_040312.1 E1 protein [human papillomavirus 18]

    See identical proteins and their annotated locations for NP_040312.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P06789, Q84181
    UniProtKB/TrEMBL
    Q80B72
    Conserved Domains (3) summary
    PHA02774
    Location:1 → 657
    PHA02774; E1; Provisional
    pfam00524
    Location:1 → 141
    PPV_E1_N; E1 Protein, N terminal domain
    cl24009
    Location:217 → 648
    Parvo_NS1; Parvovirus non-structural protein NS1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P06789.1

Gene LinkOut

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