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L1 major capsid L1 protein [ human papillomavirus 18 ]

Gene ID: 1489090, updated on 18-Aug-2023

Summary

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Gene symbol
L1
Gene description
major capsid L1 protein
Locus tag
HpV18gp8
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
human papillomavirus 18
Lineage
Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Alphapapillomavirus
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Genomic context

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Sequence:
NC_001357.1 (5430..7136)

NC_001357.1Genomic Context describing neighboring genes Neighboring gene E2 protein Neighboring gene E4 protein Neighboring gene E5 protein Neighboring gene L2 protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001357.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Methylation of the human papillomavirus-18 L1 gene: a biomarker of neoplastic progression? Turan T, et al. Virology, 2006 May 25. PMID 16472835
  2. Physicochemical characterization and immunological properties of Pichia pastoris based HPV16L1 and 18L1 virus like particles. Gupta G, et al. Biologicals, 2017 Mar. PMID 28012703
  3. Nucleotide sequence and comparative analysis of the human papillomavirus type 18 genome. Phylogeny of papillomaviruses and repeated structure of the E6 and E7 gene products. Cole ST, et al. J Mol Biol, 1987 Feb 20. PMID 3039146

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HPVL1 proteins (16L1 and 18L1) are expressed in Pichia pastoris at high levels.
    Title: Physicochemical characterization and immunological properties of Pichia pastoris based HPV16L1 and 18L1 virus like particles.
  2. L1 sequences were strongly methylated in all cervical carcinomas studied; hypothesize that L1 is preferentially methylated after integration of the HPV genome into the cellular DNA
    Title: Methylation of the human papillomavirus-18 L1 gene: a biomarker of neoplastic progression?
Submit: New GeneRIF Correction

General protein information

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Preferred Names
major capsid L1 protein
NP_040317.1
  • major capsid L1 protein; Two structural proteins are involved in papillomavirus capsid formation, a major (L1) and a minor (L2) protein; L1 forms the pentameric assembly unit of the viral shell while L2 mediates several facets of viral entry including endosomal escape after uncoating

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001357.1 Reference assembly

    Range
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_040317.1 L1 protein [human papillomavirus 18]

    See identical proteins and their annotated locations for NP_040317.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P06794, Q84270
    UniProtKB/TrEMBL
    A0A3G2LCR0, Q80B70
    Conserved Domains (1) summary
    PHA02778
    Location:62 → 565
    PHA02778; major capsid L1 protein; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P06794.1

Gene LinkOut

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