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ORF6 ORF6 protein [ SARS coronavirus Tor2 ]

Gene ID: 1489673, updated on 7-Jul-2024

Summary

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Gene symbol
ORF6
Gene description
ORF6 protein
Locus tag
sars6
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
SARS coronavirus Tor2 (isolate: Tor2, nat-host: Homo sapiens; patient #2 with severe acute respiratory syndrome (SARS))
Lineage
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; Betacoronavirus; Sarbecovirus
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Genomic context

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Sequence:
NC_004718.3 (26913..27265)

NC_004718.3Genomic Context describing neighboring genes Neighboring gene ORF3a protein Neighboring gene ORF3b protein Neighboring gene small envelope protein Neighboring gene membrane glycoprotein M Neighboring gene ORF7a protein Neighboring gene ORF7b protein Neighboring gene ORF8a protein Neighboring gene ORF8b protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_004718.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Severe acute respiratory syndrome coronavirus protein 6 accelerates murine hepatitis virus infections by more than one mechanism. Hussain S, et al. J Virol, 2008 Jul. PMID 18448520, Free PMC Article
  2. Severe acute respiratory syndrome coronavirus accessory protein 6 is a virion-associated protein and is released from 6 protein-expressing cells. Huang C, et al. J Virol, 2007 May. PMID 17344286, Free PMC Article
  3. Severe acute respiratory syndrome coronavirus accessory proteins 6 and 9b interact in vivo. Calvo E, et al. Virus Res, 2012 Oct. PMID 22820404, Free PMC Article
  4. The nonstructural protein 8 (nsp8) of the SARS coronavirus interacts with its ORF6 accessory protein. Kumar P, et al. Virology, 2007 Sep 30. PMID 17532020, Free PMC Article
  5. Structural basis for Sarbecovirus ORF6 mediated blockage of nucleocytoplasmic transport. Gao X, et al. Nat Commun, 2022 Aug 15. PMID 35970938, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results showed that SARS coronavirus protein 6 can promote the ubiquitin-dependent proteosomal degradation of Nmi.
    Title: Severe acute respiratory syndrome coronavirus protein 6 mediates ubiquitin-dependent proteosomal degradation of N-Myc (and STAT) interactor.
  2. Protein 6 immunoprecipitation from extracts of SARS-CoV infected cells and mass spectrometry analysis revealed an interaction of viral proteins 6 and 9b in biologically relevant conditions.
    Title: Severe acute respiratory syndrome coronavirus accessory proteins 6 and 9b interact in vivo.
  3. Thus, the SARS-CoV protein 6 accelerates murine hepatitis virus infections by more than one mechanism.
    Title: Severe acute respiratory syndrome coronavirus protein 6 accelerates murine hepatitis virus infections by more than one mechanism.
  4. study demonstrated that the SCoV 6 protein, which is one of the accessory proteins of SCoV, was incorporated into virus particles; infected cells released SCoV 6 protein only in association with SCoV particles
    Title: Severe acute respiratory syndrome coronavirus accessory protein 6 is a virion-associated protein and is released from 6 protein-expressing cells.
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Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General protein information

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Preferred Names
ORF6 protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004718.3 Reference assembly

    Range
    26913..27265
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_009825056.1 ORF6 protein [SARS coronavirus Tor2]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P59634, Q7T6R9, Q7TA25, Q7TFA7, Q80BV3
    UniProtKB/TrEMBL
    A0A0U1WHJ7, A0A2D1PX90, A0A2D1PXA1, A0A2D1PXE4, A0A3G5BIZ0, B8Q8Q8, B8Q8R9, B8Q8T1, B8Q8U2, B8Q8V3, B8Q8W4, C4P6R2, D2DJW9, D2E1D7, D2E1F2, D2E1L1, D2E226, D2E270, D2E2E3, D3KDN0, F2YKG7, J9TC54, Q19QW5, Q1EFM7, Q1EFP0, Q1T6X1, Q3S2C0, Q3ZTC0, Q3ZTD5, Q3ZTE8, Q4JDP9, Q4JDR2, Q5Y182, Q6RCW0, Q6RCX1, Q6RCY2, Q6RCZ3, Q6RD04, Q6RD15, Q6RD26, Q6RD37, Q6RD48, Q6RD59, Q6S8D2, Q6T1D7, Q6TPE3, Q6VA73, Q6VA84, Q6VA95, Q76Y00
    Conserved Domains (1) summary
    pfam12133
    Location:1 → 62
    Sars6; Open reading frame 6 from SARS coronavirus
Nucleotide Protein
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