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H13 histocompatibility 13 [ Mus musculus (house mouse) ]

Gene ID: 14950, updated on 2-Nov-2024

Summary

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Official Symbol
H13provided by MGI
Official Full Name
histocompatibility 13provided by MGI
Primary source
MGI:MGI:95886
See related
Ensembl:ENSMUSG00000019188 AllianceGenome:MGI:95886
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Spp; H-13; Hm13; PSL3; 1200006O09Rik; 4930443L17Rik; 5031424B04Rik
Summary
Predicted to enable aspartic endopeptidase activity, intramembrane cleaving; protein homodimerization activity; and ubiquitin protein ligase binding activity. Acts upstream of or within in utero embryonic development. Located in cell surface and endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; brain; embryo ectoderm; extraembryonic component; and musculoskeletal system. Orthologous to human HM13 (histocompatibility minor 13). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 32.1), ovary adult (RPKM 28.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See H13 in Genome Data Viewer
Location:
2 H1; 2 75.41 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (152511292..152550590)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (152669422..152708668)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700030C14 gene Neighboring gene STARR-seq mESC enhancer starr_06065 Neighboring gene predicted gene, 31791 Neighboring gene STARR-positive B cell enhancer ABC_E2648 Neighboring gene STARR-seq mESC enhancer starr_06066 Neighboring gene malignant T cell amplified sequence 2 Neighboring gene STARR-seq mESC enhancer starr_06068 Neighboring gene inhibitor of DNA binding 1, HLH protein Neighboring gene high mobility group box 1-like pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. How H13 histocompatibility peptides differing by a single methyl group and lacking conventional MHC binding anchor motifs determine self-nonself discrimination. Ostrov DA, et al. J Immunol, 2002 Jan 1. PMID 11751972
  2. The alleles of theH-13 locus. Graff RJ, et al. Immunogenetics, 1978 Dec. PMID 21302096
  3. Regulation of alternative polyadenylation by genomic imprinting. Wood AJ, et al. Genes Dev, 2008 May 1. PMID 18451104, Free PMC Article
  4. New role of signal peptide peptidase to liberate C-terminal peptides for MHC class I presentation. Oliveira CC, et al. J Immunol, 2013 Oct 15. PMID 24048903
  5. Induction of obliterative airway disease in murine tracheal allografts by CD8+ CTLs recognizing a single minor histocompatibility antigen. Higuchi T, et al. J Immunol, 2005 Feb 15. PMID 15699113

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. silencing of SPP and its family member SPPL2a led to a general reduction of surface peptide-MHC-I complexes, underlining the involvement of these enzymes in Ag processing and presentation.
    Title: New role of signal peptide peptidase to liberate C-terminal peptides for MHC class I presentation.
  2. Results show that two genetic systems show that alleles lacking methylation generate truncated H13 transcripts that undergo internal polyadenylation.
    Title: Regulation of alternative polyadenylation by genomic imprinting.
  3. new splice variant,signal peptide peptidase (SPP)beta, with an additional in-frame exon inserted between exons 11 and 12 of SPPalpha
    Title: Cell-surface expression of a new splice variant of the mouse signal peptide peptidase.
  4. widespread expression of SPP in many tissues; a distinct pattern of expression in the mature murine brain and during development indicates that SPP plays an important role in the establishment and maintenance of the nervous system
    Title: Expression of the presenilin-like signal peptide peptidase (SPP) in mouse adult brain and during development.
  5. A single minor histocompatibility antigen mismatch at the polymorphic H13 allele plays a role in chronic allograft rejection of solid organs such as obliterative airway disease development following murine tracheal transplantation.
    Title: Induction of obliterative airway disease in murine tracheal allografts by CD8+ CTLs recognizing a single minor histocompatibility antigen.
  6. structural analysis of H13 peptides lacking MHC binding anchor motifs determines self-nonself discrimination
    Title: How H13 histocompatibility peptides differing by a single methyl group and lacking conventional MHC binding anchor motifs determine self-nonself discrimination.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aspartic endopeptidase activity, intramembrane cleaving IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aspartic endopeptidase activity, intramembrane cleaving ISO
Inferred from Sequence Orthology
more info
  
enables aspartic endopeptidase activity, intramembrane cleaving ISS
Inferred from Sequence or Structural Similarity
more info
  
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables peptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in membrane protein proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in membrane protein proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in membrane protein proteolysis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in membrane protein proteolysis involved in retrograde protein transport, ER to cytosol IEA
Inferred from Electronic Annotation
more info
  
involved_in membrane protein proteolysis involved in retrograde protein transport, ER to cytosol ISO
Inferred from Sequence Orthology
more info
  
involved_in signal peptide processing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Derlin-1 retrotranslocation complex IEA
Inferred from Electronic Annotation
more info
  
part_of Derlin-1 retrotranslocation complex ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasmic side of endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic side of endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in lumenal side of endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lumenal side of endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lumenal side of endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in rough endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in rough endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
minor histocompatibility antigen H13
Names
presenilin-like aspartyl protease
presenilin-like protein 3
signal peptide peptidase beta
NP_001153023.1
NP_001153024.1
NP_001153025.1
NP_034506.1
XP_006498846.1
XP_017171155.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159551.2 → NP_001153023.1  minor histocompatibility antigen H13 isoform 1

    See identical proteins and their annotated locations for NP_001153023.1

    Status: VALIDATED

    Source sequence(s)
    AL845162
    Consensus CDS
    CCDS50752.1
    UniProtKB/TrEMBL
    A3KGR9
    Related
    ENSMUSP00000086460.3, ENSMUST00000089059.9
    Conserved Domains (1) summary
    pfam04258
    Location:62 → 350
    Peptidase_A22B; Signal peptide peptidase

  2. NM_001159552.2 → NP_001153024.1  minor histocompatibility antigen H13 isoform 3

    See identical proteins and their annotated locations for NP_001153024.1

    Status: VALIDATED

    Source sequence(s)
    AL845162
    Consensus CDS
    CCDS50753.1
    UniProtKB/TrEMBL
    Q6PGJ8, Q8HWB1
    Related
    ENSMUSP00000105450.2, ENSMUST00000109825.8
    Conserved Domains (1) summary
    cl01342
    Location:62 → 145
    Peptidase_A22B; Signal peptide peptidase

  3. NM_001159553.2 → NP_001153025.1  minor histocompatibility antigen H13 isoform 4

    See identical proteins and their annotated locations for NP_001153025.1

    Status: VALIDATED

    Source sequence(s)
    AL845162
    UniProtKB/Swiss-Prot
    Q9D8V0
    Conserved Domains (1) summary
    cl01342
    Location:62 → 123
    Peptidase_A22B; Signal peptide peptidase

  4. NM_010376.5 → NP_034506.1  minor histocompatibility antigen H13 isoform 2

    See identical proteins and their annotated locations for NP_034506.1

    Status: VALIDATED

    Source sequence(s)
    AL845162
    Consensus CDS
    CCDS16896.1
    UniProtKB/Swiss-Prot
    A3KGS1, O19444, Q15K37, Q3TXP0, Q542R3, Q811Z6, Q8HWA9, Q8HWB5, Q9CQA4, Q9CSK9, Q9D8V0
    UniProtKB/TrEMBL
    A3KGR9
    Related
    ENSMUSP00000120068.2, ENSMUST00000125366.8
    Conserved Domains (1) summary
    pfam04258
    Location:62 → 350
    Peptidase_A22B; Signal peptide peptidase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    152511292..152550590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498783.5 → XP_006498846.1  minor histocompatibility antigen H13 isoform X2

    UniProtKB/TrEMBL
    A3KGR9
    Related
    ENSMUSP00000078236.4, ENSMUST00000079247.4
    Conserved Domains (1) summary
    pfam04258
    Location:62 → 350
    Peptidase_A22B; Signal peptide peptidase

  2. XM_017315666.3 → XP_017171155.1  minor histocompatibility antigen H13 isoform X1

    Conserved Domains (1) summary
    cl01342
    Location:50 → 157
    Peptidase_A22B; Signal peptide peptidase

RNA

  1. XR_001780858.3 RNA Sequence

  2. XR_374416.3 RNA Sequence

  3. XR_003950808.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D8V0.1 GenPept UniProtKB/Swiss-Prot:Q9D8V0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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